Targeted SPP1 Inhibition of Tumor‐Associated Myeloid Cells Effectively Decreases Tumor Sizes

Targeted SPP1 Inhibition of Tumor‐Associated Myeloid Cells Effectively Decreases Tumor Sizes

Abstract Secreted phosphosprotein 1 (SPP1)High tumor‐associated macrophages (TAM) are abundant tumor myeloid cells that are immunosuppressive, pro‐tumorigenic, and have a highly negative prognostic factor. Despite this, there is a lack of efficient TAM‐specific therapeutics capable of reducing SPP1...

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Main Authors: Benan Kartal, Christopher S. Garris, Hyung Shik Kim, Rainer H. Kohler, Jasmine Carrothers, Elias A. Halabi, Yoshiko Iwamoto, Anne‐Gaëlle Goubet, Yuxuan Xie, Pratyaksha Wirapati, Mikaël J. Pittet, Ralph Weissleder
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
cancer
macrophage
nanoparticles
SPP1
Online Access:https://doi.org/10.1002/advs.202410360
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