Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion
Objective To investigate the causal relationship between fibroblast growth factors (FGFs), their receptors (FGFRs) and spontaneous abortion (SA). Methods FGFs, FGFRs, and SA related GWAS data were obtained from the FinnGen Alliance and Genome-wide Association Studies Databases. Using MR analysis met...
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| Format: | Article |
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Editorial Office of New Medicine
2025-06-01
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| Series: | Yixue xinzhi zazhi |
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| Online Access: | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2506/b1k5ZFwf8Pd5Dd5IJyCQrXb6KTNCCduKwKvldxqF.pdf |
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| author | LI Jing SUN Caixuan LI Ao XUE Yilu WANG Runlin TANG Yuyun CAO Yuanyuan |
| author_facet | LI Jing SUN Caixuan LI Ao XUE Yilu WANG Runlin TANG Yuyun CAO Yuanyuan |
| author_sort | LI Jing |
| collection | DOAJ |
| description | Objective To investigate the causal relationship between fibroblast growth factors (FGFs), their receptors (FGFRs) and spontaneous abortion (SA). Methods FGFs, FGFRs, and SA related GWAS data were obtained from the FinnGen Alliance and Genome-wide Association Studies Databases. Using MR analysis method to explore the causal relationship between FGFs, FGFRs and SA, with the inverse-variance weighted method (IVW) as the main analysis method. Sensitivity analysis was conducted using MR-PRESSO, MR Egger, Cochran's Q, and the leave-one-out method. Results A total of 22 exposure factors were selected. The IVW results showed that FGF22 increased the risk of SA [OR=1.099, 95%CI (1.001, 1.206), P=0.047], while FGF12 decreased the risk of SA [OR=0.858, 95%CI (0.774, 0.951), P=0.003]. There were no significant causal associations between other FGFs, FGFRs, and SA. Sensitivity analysis conducted on the causal association between FGF12, FGF22, and SA showed that Cochran's Q test (P>0.05) indicated no heterogeneity, MR Egger test (P>0.05) indicated no horizontal pleiotropy, MR-PRESSO method did not detect outliers and no SNPs that had a significant impact on the results were detected using leave-one-out method. Conclusion FGF12 is a protective factor for SA, while FGF22 is a risk factor for SA. The result provide potential molecular markers for early prediction and targeted intervention of SA. |
| format | Article |
| id | doaj-art-463126c9974c4e10915bf3efa0015e3a |
| institution | DOAJ |
| issn | 1004-5511 |
| language | zho |
| publishDate | 2025-06-01 |
| publisher | Editorial Office of New Medicine |
| record_format | Article |
| series | Yixue xinzhi zazhi |
| spelling | doaj-art-463126c9974c4e10915bf3efa0015e3a2025-08-20T03:23:56ZzhoEditorial Office of New MedicineYixue xinzhi zazhi1004-55112025-06-0135668068710.12173/j.issn.1004-5511.2024120536663Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortionLI JingSUN CaixuanLI AoXUE YiluWANG RunlinTANG YuyunCAO YuanyuanObjective To investigate the causal relationship between fibroblast growth factors (FGFs), their receptors (FGFRs) and spontaneous abortion (SA). Methods FGFs, FGFRs, and SA related GWAS data were obtained from the FinnGen Alliance and Genome-wide Association Studies Databases. Using MR analysis method to explore the causal relationship between FGFs, FGFRs and SA, with the inverse-variance weighted method (IVW) as the main analysis method. Sensitivity analysis was conducted using MR-PRESSO, MR Egger, Cochran's Q, and the leave-one-out method. Results A total of 22 exposure factors were selected. The IVW results showed that FGF22 increased the risk of SA [OR=1.099, 95%CI (1.001, 1.206), P=0.047], while FGF12 decreased the risk of SA [OR=0.858, 95%CI (0.774, 0.951), P=0.003]. There were no significant causal associations between other FGFs, FGFRs, and SA. Sensitivity analysis conducted on the causal association between FGF12, FGF22, and SA showed that Cochran's Q test (P>0.05) indicated no heterogeneity, MR Egger test (P>0.05) indicated no horizontal pleiotropy, MR-PRESSO method did not detect outliers and no SNPs that had a significant impact on the results were detected using leave-one-out method. Conclusion FGF12 is a protective factor for SA, while FGF22 is a risk factor for SA. The result provide potential molecular markers for early prediction and targeted intervention of SA.https://yxxz.whuznhmedj.com/futureApi/storage/attach/2506/b1k5ZFwf8Pd5Dd5IJyCQrXb6KTNCCduKwKvldxqF.pdfspontaneous abortionfibroblast growth factorfibroblast growth factor receptormendelian randomization |
| spellingShingle | LI Jing SUN Caixuan LI Ao XUE Yilu WANG Runlin TANG Yuyun CAO Yuanyuan Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion Yixue xinzhi zazhi spontaneous abortion fibroblast growth factor fibroblast growth factor receptor mendelian randomization |
| title | Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion |
| title_full | Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion |
| title_fullStr | Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion |
| title_full_unstemmed | Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion |
| title_short | Mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion |
| title_sort | mendelian randomization study on the relationship between fibroblast growth factors and their receptors and the risk of spontaneous abortion |
| topic | spontaneous abortion fibroblast growth factor fibroblast growth factor receptor mendelian randomization |
| url | https://yxxz.whuznhmedj.com/futureApi/storage/attach/2506/b1k5ZFwf8Pd5Dd5IJyCQrXb6KTNCCduKwKvldxqF.pdf |
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