Recent advancements in molecular photoacoustic tomography
Photoacoustic tomography (PAT) is an emerging biomedical imaging technology that combines the molecular sensitivity of optical imaging with the spatial resolution of ultrasonic imaging in deep tissue. Molecular PAT, a subset of PAT, takes advantage of the specific absorption of molecules to reveal t...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IOP Publishing
2025-01-01
|
| Series: | JPhys Photonics |
| Subjects: | |
| Online Access: | https://doi.org/10.1088/2515-7647/adf167 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849701311191187456 |
|---|---|
| author | Eric Hall Chengyun Tang Lei Li |
| author_facet | Eric Hall Chengyun Tang Lei Li |
| author_sort | Eric Hall |
| collection | DOAJ |
| description | Photoacoustic tomography (PAT) is an emerging biomedical imaging technology that combines the molecular sensitivity of optical imaging with the spatial resolution of ultrasonic imaging in deep tissue. Molecular PAT, a subset of PAT, takes advantage of the specific absorption of molecules to reveal tissue structures, functions, and dynamics. Thanks to the high sensitivity to the optical absorption of molecules, PAT can selectively image those molecules by tuning the excitation wavelength to each target’s optical absorption signature. PAT has imaged various molecular targets in vivo , ranging from endogenous chromophores, e.g. hemoglobin, melanin, and lipids, to specialized exogenous contrasts such as organic dyes, genetically encoded proteins, and nano/microparticles. Each molecular contrast hosts inherent advantages. Endogenous contrasts allow for truly noninvasive imaging but cannot attain high specificity or sensitivity for many biological processes, whereas artificial exogenous contrasts can. Recent advances in imaging these contrast agents have shown the immense potential of photoacoustic imaging for diagnosing, monitoring, and treating medical conditions, along with studying the fundamental processes in vivo . |
| format | Article |
| id | doaj-art-462dc3523a5e450183a387ee32d00c56 |
| institution | DOAJ |
| issn | 2515-7647 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IOP Publishing |
| record_format | Article |
| series | JPhys Photonics |
| spelling | doaj-art-462dc3523a5e450183a387ee32d00c562025-08-20T03:17:58ZengIOP PublishingJPhys Photonics2515-76472025-01-017303200310.1088/2515-7647/adf167Recent advancements in molecular photoacoustic tomographyEric Hall0https://orcid.org/0000-0002-4301-6964Chengyun Tang1https://orcid.org/0009-0000-9955-5601Lei Li2https://orcid.org/0000-0001-6164-2646Department of Electrical and Computer Engineering, Rice University , Houston, TX, United States of America; Texas A&M School of Engineering Medicine , Houston, TX, United States of AmericaDepartment of Electrical and Computer Engineering, Rice University , Houston, TX, United States of AmericaDepartment of Electrical and Computer Engineering, Rice University , Houston, TX, United States of America; Department of Bioengineering, Rice University , Houston, TX, United States of AmericaPhotoacoustic tomography (PAT) is an emerging biomedical imaging technology that combines the molecular sensitivity of optical imaging with the spatial resolution of ultrasonic imaging in deep tissue. Molecular PAT, a subset of PAT, takes advantage of the specific absorption of molecules to reveal tissue structures, functions, and dynamics. Thanks to the high sensitivity to the optical absorption of molecules, PAT can selectively image those molecules by tuning the excitation wavelength to each target’s optical absorption signature. PAT has imaged various molecular targets in vivo , ranging from endogenous chromophores, e.g. hemoglobin, melanin, and lipids, to specialized exogenous contrasts such as organic dyes, genetically encoded proteins, and nano/microparticles. Each molecular contrast hosts inherent advantages. Endogenous contrasts allow for truly noninvasive imaging but cannot attain high specificity or sensitivity for many biological processes, whereas artificial exogenous contrasts can. Recent advances in imaging these contrast agents have shown the immense potential of photoacoustic imaging for diagnosing, monitoring, and treating medical conditions, along with studying the fundamental processes in vivo .https://doi.org/10.1088/2515-7647/adf167photoacoustic tomography (PAT)photoacoustic microscopy (PAM)molecular photoacoustic tomographymolecular imagingendogenous contrastexogenous contrast |
| spellingShingle | Eric Hall Chengyun Tang Lei Li Recent advancements in molecular photoacoustic tomography JPhys Photonics photoacoustic tomography (PAT) photoacoustic microscopy (PAM) molecular photoacoustic tomography molecular imaging endogenous contrast exogenous contrast |
| title | Recent advancements in molecular photoacoustic tomography |
| title_full | Recent advancements in molecular photoacoustic tomography |
| title_fullStr | Recent advancements in molecular photoacoustic tomography |
| title_full_unstemmed | Recent advancements in molecular photoacoustic tomography |
| title_short | Recent advancements in molecular photoacoustic tomography |
| title_sort | recent advancements in molecular photoacoustic tomography |
| topic | photoacoustic tomography (PAT) photoacoustic microscopy (PAM) molecular photoacoustic tomography molecular imaging endogenous contrast exogenous contrast |
| url | https://doi.org/10.1088/2515-7647/adf167 |
| work_keys_str_mv | AT erichall recentadvancementsinmolecularphotoacoustictomography AT chengyuntang recentadvancementsinmolecularphotoacoustictomography AT leili recentadvancementsinmolecularphotoacoustictomography |