Distribution and Antimicrobial Resistance Analysis of Blood Culture Isolates at a Chinese National Cardiovascular Regional Medical Center: A 7-Year Retrospective Study
Qian Wang, Fan Wu, Tao Li Department of Medical Laboratory, Fuwai Central China Cardiovascular Hospital/Central China Fuwai Hospital of Zhengzhou University/Henan Provincial People’s Hospital, Zhengzhou, Henan, 451464, People’s Republic of ChinaCorrespondence: Tao Li, Department of Medical Laborator...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-08-01
|
| Series: | Infection and Drug Resistance |
| Subjects: | |
| Online Access: | https://www.dovepress.com/distribution-and-antimicrobial-resistance-analysis-of-blood-culture-is-peer-reviewed-fulltext-article-IDR |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849225469546725376 |
|---|---|
| author | Wang Q Wu F Li T |
| author_facet | Wang Q Wu F Li T |
| author_sort | Wang Q |
| collection | DOAJ |
| description | Qian Wang, Fan Wu, Tao Li Department of Medical Laboratory, Fuwai Central China Cardiovascular Hospital/Central China Fuwai Hospital of Zhengzhou University/Henan Provincial People’s Hospital, Zhengzhou, Henan, 451464, People’s Republic of ChinaCorrespondence: Tao Li, Department of Medical Laboratory, Fuwai Central China Cardiovascular Hospital/Central China Fuwai Hospital of Zhengzhou University/Henan Provincial People’s Hospital, Zhengzhou, Henan, 451464, People’s Republic of China, Email zzlitao@zzu.edu.cnPurpose: This study aimed to characterize the epidemiological patterns and antimicrobial resistance profiles of bloodstream infections (BSIs) in a cardiovascular specialty hospital and to identify region-specific pathogen distributions, resistance risks, and clinical implications for optimizing empirical therapy and infection control strategies.Patients and Methods: A retrospective analysis (2018– 2024) evaluated 1,055 non-duplicate BSI isolates from 37,576 blood cultures at the Fuwai Central China Cardiovascular Hospital. Researchers investigated both bacterial classification and associated drug resistance through comprehensive analysis.Results: The study revealed that a total of 1,055 bacterial strains were isolated from blood cultures, with Gram-negative bacteria accounting for 31.5% (332 strains), Gram-positive bacteria for 62.7% (662 strains), and fungi for 5.8% (61 strains). The most frequently isolated pathogens were Staphylococcus epidermidis (13.7%), Staphylococcus hominis (8.0%), Klebsiella pneumoniae (7.4%), Escherichia coli (7.1%), and Staphylococcus haemolyticus (6.7%). These pathogens were predominantly isolated from intensive care units (ICUs), with the Coronary Heart Disease ICU (24.7%), General ICU (18.0%), and Adult Cardiac Surgery ICU (8.1%) representing the top three departments for bacterial detection. Among Staphylococcus isolates, methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococci (MRCNS) were identified at rates of 51.6% and 88.7%, respectively. The carbapenem resistance rates of K. pneumoniae and E. coli were 28.8% and 4.0%, respectively. Non-fermenting Gram-negative bacilli, such as Acinetobacter baumannii, showed alarming resistance rates to carbapenems (60.0%) and other β-lactams (≥ 52%), while Burkholderia cepacia and Stenotrophomonas maltophilia remained highly susceptible to first-line agents.Conclusion: Blood culture isolates in our hospital demonstrated a predominance of Gram-positive organisms, with high detection rates of MRSA, MRCNS, and carbapenem-resistant Gram-negative bacilli. Continuous antimicrobial resistance surveillance of bloodstream isolates should be maintained in clinical practice to provide evidence-based data for rational antibiotic use and mitigate the emergence of resistant pathogens.Keywords: bloodstream infections, antimicrobial resistance, multidrug-resistant organisms, antibacterial drugs |
| format | Article |
| id | doaj-art-46288c345be640c5919f50e3502a4733 |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj-art-46288c345be640c5919f50e3502a47332025-08-24T17:31:58ZengDove Medical PressInfection and Drug Resistance1178-69732025-08-01Volume 18Issue 142494262106081Distribution and Antimicrobial Resistance Analysis of Blood Culture Isolates at a Chinese National Cardiovascular Regional Medical Center: A 7-Year Retrospective StudyWang Q0Wu FLi TDepartment of Medical LaboratoryQian Wang, Fan Wu, Tao Li Department of Medical Laboratory, Fuwai Central China Cardiovascular Hospital/Central China Fuwai Hospital of Zhengzhou University/Henan Provincial People’s Hospital, Zhengzhou, Henan, 451464, People’s Republic of ChinaCorrespondence: Tao Li, Department of Medical Laboratory, Fuwai Central China Cardiovascular Hospital/Central China Fuwai Hospital of Zhengzhou University/Henan Provincial People’s Hospital, Zhengzhou, Henan, 451464, People’s Republic of China, Email zzlitao@zzu.edu.cnPurpose: This study aimed to characterize the epidemiological patterns and antimicrobial resistance profiles of bloodstream infections (BSIs) in a cardiovascular specialty hospital and to identify region-specific pathogen distributions, resistance risks, and clinical implications for optimizing empirical therapy and infection control strategies.Patients and Methods: A retrospective analysis (2018– 2024) evaluated 1,055 non-duplicate BSI isolates from 37,576 blood cultures at the Fuwai Central China Cardiovascular Hospital. Researchers investigated both bacterial classification and associated drug resistance through comprehensive analysis.Results: The study revealed that a total of 1,055 bacterial strains were isolated from blood cultures, with Gram-negative bacteria accounting for 31.5% (332 strains), Gram-positive bacteria for 62.7% (662 strains), and fungi for 5.8% (61 strains). The most frequently isolated pathogens were Staphylococcus epidermidis (13.7%), Staphylococcus hominis (8.0%), Klebsiella pneumoniae (7.4%), Escherichia coli (7.1%), and Staphylococcus haemolyticus (6.7%). These pathogens were predominantly isolated from intensive care units (ICUs), with the Coronary Heart Disease ICU (24.7%), General ICU (18.0%), and Adult Cardiac Surgery ICU (8.1%) representing the top three departments for bacterial detection. Among Staphylococcus isolates, methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative Staphylococci (MRCNS) were identified at rates of 51.6% and 88.7%, respectively. The carbapenem resistance rates of K. pneumoniae and E. coli were 28.8% and 4.0%, respectively. Non-fermenting Gram-negative bacilli, such as Acinetobacter baumannii, showed alarming resistance rates to carbapenems (60.0%) and other β-lactams (≥ 52%), while Burkholderia cepacia and Stenotrophomonas maltophilia remained highly susceptible to first-line agents.Conclusion: Blood culture isolates in our hospital demonstrated a predominance of Gram-positive organisms, with high detection rates of MRSA, MRCNS, and carbapenem-resistant Gram-negative bacilli. Continuous antimicrobial resistance surveillance of bloodstream isolates should be maintained in clinical practice to provide evidence-based data for rational antibiotic use and mitigate the emergence of resistant pathogens.Keywords: bloodstream infections, antimicrobial resistance, multidrug-resistant organisms, antibacterial drugshttps://www.dovepress.com/distribution-and-antimicrobial-resistance-analysis-of-blood-culture-is-peer-reviewed-fulltext-article-IDRbloodstream infectionsantimicrobial resistancemultidrug-resistant organismsantibacterial drugs |
| spellingShingle | Wang Q Wu F Li T Distribution and Antimicrobial Resistance Analysis of Blood Culture Isolates at a Chinese National Cardiovascular Regional Medical Center: A 7-Year Retrospective Study Infection and Drug Resistance bloodstream infections antimicrobial resistance multidrug-resistant organisms antibacterial drugs |
| title | Distribution and Antimicrobial Resistance Analysis of Blood Culture Isolates at a Chinese National Cardiovascular Regional Medical Center: A 7-Year Retrospective Study |
| title_full | Distribution and Antimicrobial Resistance Analysis of Blood Culture Isolates at a Chinese National Cardiovascular Regional Medical Center: A 7-Year Retrospective Study |
| title_fullStr | Distribution and Antimicrobial Resistance Analysis of Blood Culture Isolates at a Chinese National Cardiovascular Regional Medical Center: A 7-Year Retrospective Study |
| title_full_unstemmed | Distribution and Antimicrobial Resistance Analysis of Blood Culture Isolates at a Chinese National Cardiovascular Regional Medical Center: A 7-Year Retrospective Study |
| title_short | Distribution and Antimicrobial Resistance Analysis of Blood Culture Isolates at a Chinese National Cardiovascular Regional Medical Center: A 7-Year Retrospective Study |
| title_sort | distribution and antimicrobial resistance analysis of blood culture isolates at a chinese national cardiovascular regional medical center a 7 year retrospective study |
| topic | bloodstream infections antimicrobial resistance multidrug-resistant organisms antibacterial drugs |
| url | https://www.dovepress.com/distribution-and-antimicrobial-resistance-analysis-of-blood-culture-is-peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT wangq distributionandantimicrobialresistanceanalysisofbloodcultureisolatesatachinesenationalcardiovascularregionalmedicalcentera7yearretrospectivestudy AT wuf distributionandantimicrobialresistanceanalysisofbloodcultureisolatesatachinesenationalcardiovascularregionalmedicalcentera7yearretrospectivestudy AT lit distributionandantimicrobialresistanceanalysisofbloodcultureisolatesatachinesenationalcardiovascularregionalmedicalcentera7yearretrospectivestudy |