Comparison of Different Ketofol Procedural Sedation and Analgesic Doses during Orthopedic Procedures in Patients Referred to the Emergency Department
Background: Orthopedic procedures are one of the most common medical procedures in the Emergency Department (ED) and are also among the most painful procedures performed on the conscious patient. This study aimed to compare different doses of ketofol in procedural sedation and analgesia in patients...
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| Format: | Article |
| Language: | English |
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Discover STM Publishing Ltd
2024-03-01
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| Series: | Saudi Journal of Emergency Medicine |
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| Online Access: | https://sjemed.com/?mno=193707 |
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| author | Saeed Abbasi Kourosh Javdani Esfehani Majid Ghodsipoor Davood Farsi Mahdi Rezai Peyman Hafezimoghadam Mani Mofidi Nazanin Alaei Faradonbeh |
| author_facet | Saeed Abbasi Kourosh Javdani Esfehani Majid Ghodsipoor Davood Farsi Mahdi Rezai Peyman Hafezimoghadam Mani Mofidi Nazanin Alaei Faradonbeh |
| author_sort | Saeed Abbasi |
| collection | DOAJ |
| description | Background:
Orthopedic procedures are one of the most common medical procedures in the Emergency Department (ED) and are also among the most painful procedures performed on the conscious patient. This study aimed to compare different doses of ketofol in procedural sedation and analgesia in patients referred to the EDs.
Methods:
In this double-blinded clinical trial, 296 patients aged 18 years or over presented with the need for orthopedic procedures in the three academic EDs in 2020 were studied. After completing the written consent, the patients were randomly assigned to four treatment groups. Demographic information, underlying diseases, patients' physical condition, type of orthopedic injuries requiring intervention, and patients' vital signs were recorded in a checklist for each patient.
Results:
In this study, the mean age, gender, level of education, addiction, patients' physical condition, type of procedures performed, apnea, hypoventilation, bradycardia, hypotension, and agitation in all four treatment groups were not statistically different, but hallucination and hypoxia in group C (1: 3) were much less than other groups; thus, oxygen administration was more common in other groups.
Conclusion:
By testing different doses of ketamine, we concluded that doses of 1 mg and 0.5 mg were associated with more side effects. A dose of 0.33 mg of ketamine has fewer side effects while causing analgesia and sedation as in the above doses. A dose of 0.25 mg of ketamine increases the likelihood of requiring subsequent doses. Therefore, it seems that 0.33 mg of ketamine is the best dose of choice. [SJEMed 2024; 5(1.100): S36-S36] |
| format | Article |
| id | doaj-art-4628888d2bee4e8bb9971ca4363566ef |
| institution | DOAJ |
| issn | 1658-8487 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Discover STM Publishing Ltd |
| record_format | Article |
| series | Saudi Journal of Emergency Medicine |
| spelling | doaj-art-4628888d2bee4e8bb9971ca4363566ef2025-08-20T02:40:30ZengDiscover STM Publishing LtdSaudi Journal of Emergency Medicine1658-84872024-03-015Emirates Society of Emergency Medicine 2023 (ESEM23) Conference AbstractsS36S3610.24911/SJEMed.72-1709967567193707Comparison of Different Ketofol Procedural Sedation and Analgesic Doses during Orthopedic Procedures in Patients Referred to the Emergency DepartmentSaeed Abbasi0Kourosh Javdani Esfehani1Majid Ghodsipoor2Davood Farsi3Mahdi Rezai4Peyman Hafezimoghadam5Mani Mofidi6Nazanin Alaei Faradonbeh7Associate Professor, Emergency Medicine Management Research Center, Health Management Research Institute, School of Medicine, Iran University of Medical Sciences Iranian Hospital Dubai, UAE Emergency Medicine Specialist, Emergency Medicine Management Research Center, Health Management Research Institute, Iran University of Medical Sciences Professor of Emergency Medicine, Emergency Medicine Management Research Center, Health Management Research Institute, School of Medicine, Iran University of Medical Sciences Associate Professor, Emergency Medicine Management Research Center, Health Management Research Institute, School of Medicine, Iran University of Medical Sciences Asscociate Professor, Emergency Medicine Management Research Center, Health Management Research Institute, School of Medicine, Iran University of Medical Sciences Professor of Emergency Medicine, Emergency Medicine Management Research Center, Health Management Research Institute, School of Medicine, Iran University of Medical Sciences, Assistant Professor, Emergency Medicine Management Research Center, Health Management Research Institute, School of Medicine, Iran University of Medical SciencesBackground: Orthopedic procedures are one of the most common medical procedures in the Emergency Department (ED) and are also among the most painful procedures performed on the conscious patient. This study aimed to compare different doses of ketofol in procedural sedation and analgesia in patients referred to the EDs. Methods: In this double-blinded clinical trial, 296 patients aged 18 years or over presented with the need for orthopedic procedures in the three academic EDs in 2020 were studied. After completing the written consent, the patients were randomly assigned to four treatment groups. Demographic information, underlying diseases, patients' physical condition, type of orthopedic injuries requiring intervention, and patients' vital signs were recorded in a checklist for each patient. Results: In this study, the mean age, gender, level of education, addiction, patients' physical condition, type of procedures performed, apnea, hypoventilation, bradycardia, hypotension, and agitation in all four treatment groups were not statistically different, but hallucination and hypoxia in group C (1: 3) were much less than other groups; thus, oxygen administration was more common in other groups. Conclusion: By testing different doses of ketamine, we concluded that doses of 1 mg and 0.5 mg were associated with more side effects. A dose of 0.33 mg of ketamine has fewer side effects while causing analgesia and sedation as in the above doses. A dose of 0.25 mg of ketamine increases the likelihood of requiring subsequent doses. Therefore, it seems that 0.33 mg of ketamine is the best dose of choice. [SJEMed 2024; 5(1.100): S36-S36]https://sjemed.com/?mno=193707orthopedic proceduresketofolprocedural sedation and analgesiapain intensity |
| spellingShingle | Saeed Abbasi Kourosh Javdani Esfehani Majid Ghodsipoor Davood Farsi Mahdi Rezai Peyman Hafezimoghadam Mani Mofidi Nazanin Alaei Faradonbeh Comparison of Different Ketofol Procedural Sedation and Analgesic Doses during Orthopedic Procedures in Patients Referred to the Emergency Department Saudi Journal of Emergency Medicine orthopedic procedures ketofol procedural sedation and analgesia pain intensity |
| title | Comparison of Different Ketofol Procedural Sedation and Analgesic Doses during Orthopedic Procedures in Patients Referred to the Emergency Department |
| title_full | Comparison of Different Ketofol Procedural Sedation and Analgesic Doses during Orthopedic Procedures in Patients Referred to the Emergency Department |
| title_fullStr | Comparison of Different Ketofol Procedural Sedation and Analgesic Doses during Orthopedic Procedures in Patients Referred to the Emergency Department |
| title_full_unstemmed | Comparison of Different Ketofol Procedural Sedation and Analgesic Doses during Orthopedic Procedures in Patients Referred to the Emergency Department |
| title_short | Comparison of Different Ketofol Procedural Sedation and Analgesic Doses during Orthopedic Procedures in Patients Referred to the Emergency Department |
| title_sort | comparison of different ketofol procedural sedation and analgesic doses during orthopedic procedures in patients referred to the emergency department |
| topic | orthopedic procedures ketofol procedural sedation and analgesia pain intensity |
| url | https://sjemed.com/?mno=193707 |
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