Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis
Background. Cytokines and growth factors involved in the tissue inflammatory process influence the outcome of Leishmania infection. Insulin-like growth factor (IGF-I) constitutively present in the skin may participate in the inflammatory process and parasite-host interaction. Previous work has shown...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/6657785 |
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| author | Carolina de O Mendes-Aguiar Camilla Lopes-Siqueira Fabrício Pettito-Assis Márcia Pereira-Oliveira Manoel Paes de Oliveira-Neto Claude Pirmez Alda Maria Da-Cruz Hiro Goto |
| author_facet | Carolina de O Mendes-Aguiar Camilla Lopes-Siqueira Fabrício Pettito-Assis Márcia Pereira-Oliveira Manoel Paes de Oliveira-Neto Claude Pirmez Alda Maria Da-Cruz Hiro Goto |
| author_sort | Carolina de O Mendes-Aguiar |
| collection | DOAJ |
| description | Background. Cytokines and growth factors involved in the tissue inflammatory process influence the outcome of Leishmania infection. Insulin-like growth factor (IGF-I) constitutively present in the skin may participate in the inflammatory process and parasite-host interaction. Previous work has shown that preincubation of Leishmania (Leishmania) amazonensis with recombinant IGF-I induces accelerated lesion development. However, in human cutaneous leishmaniasis (CL) pathogenesis, it is more relevant to the persistent inflammatory process than progressive parasite proliferation. In this context, we aimed to investigate whether IGF-I was present in the CL lesions and if this factor may influence the lesions’ development acting on parasite growth and/or on the inflammatory/healing process. Methodology. Fifty-one CL patients’ skin lesion samples from endemic area of L. (Viannia) braziliensis infection were submitted to histopathological analysis and searched for Leishmania and IGF-I expression by immunohistochemistry. Results. In human CL lesions, IGF-I was observed preferentially in the late lesion (more than 90 days), and the percentage of positive area for IGF-I was positively correlated with duration of illness (r=0.42, P<0.05). IGF-I was highly expressed in the inflammatory infiltrate of CL lesions from patients evolving with good response to therapy (2.8%±2.1%; median=2.1%; n=18) than poor responders (1.3%±1.1%; median: 1.05%; n=6; P<0.05). Conclusions. It is the first time that IGF-I was detected in lesions of infectious cutaneous disease, specifically in American tegumentary leishmaniasis. IGF-I was related to chronicity and good response to treatment. We may relate this finding to the efficient anti-inflammatory response and the known action of IGF-I in wound repair. The present data highlight the importance of searching nonspecific factors besides adaptive immune elements in the study of leishmaniasis’ pathogenesis. |
| format | Article |
| id | doaj-art-4620fcb088fe43be8adf68616d0ee9c6 |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-4620fcb088fe43be8adf68616d0ee9c62025-08-20T02:37:48ZengWileyJournal of Immunology Research2314-88612314-71562021-01-01202110.1155/2021/66577856657785Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary LeishmaniasisCarolina de O Mendes-Aguiar0Camilla Lopes-Siqueira1Fabrício Pettito-Assis2Márcia Pereira-Oliveira3Manoel Paes de Oliveira-Neto4Claude Pirmez5Alda Maria Da-Cruz6Hiro Goto7Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, BrazilLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, BrazilInstituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, BrazilLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, BrazilInstituto Nacional de Infectologia Evandro Chagas, FIOCRUZ, Rio de Janeiro, BrazilLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, BrazilLaboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, FIOCRUZ, Rio de Janeiro, BrazilInstituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de São Paulo, São Paulo, BrazilBackground. Cytokines and growth factors involved in the tissue inflammatory process influence the outcome of Leishmania infection. Insulin-like growth factor (IGF-I) constitutively present in the skin may participate in the inflammatory process and parasite-host interaction. Previous work has shown that preincubation of Leishmania (Leishmania) amazonensis with recombinant IGF-I induces accelerated lesion development. However, in human cutaneous leishmaniasis (CL) pathogenesis, it is more relevant to the persistent inflammatory process than progressive parasite proliferation. In this context, we aimed to investigate whether IGF-I was present in the CL lesions and if this factor may influence the lesions’ development acting on parasite growth and/or on the inflammatory/healing process. Methodology. Fifty-one CL patients’ skin lesion samples from endemic area of L. (Viannia) braziliensis infection were submitted to histopathological analysis and searched for Leishmania and IGF-I expression by immunohistochemistry. Results. In human CL lesions, IGF-I was observed preferentially in the late lesion (more than 90 days), and the percentage of positive area for IGF-I was positively correlated with duration of illness (r=0.42, P<0.05). IGF-I was highly expressed in the inflammatory infiltrate of CL lesions from patients evolving with good response to therapy (2.8%±2.1%; median=2.1%; n=18) than poor responders (1.3%±1.1%; median: 1.05%; n=6; P<0.05). Conclusions. It is the first time that IGF-I was detected in lesions of infectious cutaneous disease, specifically in American tegumentary leishmaniasis. IGF-I was related to chronicity and good response to treatment. We may relate this finding to the efficient anti-inflammatory response and the known action of IGF-I in wound repair. The present data highlight the importance of searching nonspecific factors besides adaptive immune elements in the study of leishmaniasis’ pathogenesis.http://dx.doi.org/10.1155/2021/6657785 |
| spellingShingle | Carolina de O Mendes-Aguiar Camilla Lopes-Siqueira Fabrício Pettito-Assis Márcia Pereira-Oliveira Manoel Paes de Oliveira-Neto Claude Pirmez Alda Maria Da-Cruz Hiro Goto Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis Journal of Immunology Research |
| title | Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis |
| title_full | Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis |
| title_fullStr | Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis |
| title_full_unstemmed | Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis |
| title_short | Dual Role of Insulin-Like Growth Factor (IGF)-I in American Tegumentary Leishmaniasis |
| title_sort | dual role of insulin like growth factor igf i in american tegumentary leishmaniasis |
| url | http://dx.doi.org/10.1155/2021/6657785 |
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