Free Cholesterol‐Induced Liver Injury in Non‐Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I

Free Cholesterol‐Induced Liver Injury in Non‐Alcoholic Fatty Liver Disease: Mechanisms and a Therapeutic Intervention Using Dihydrotanshinone I

Abstract Build‐up of free cholesterol (FC) substantially contributes to the development and severity of non‐alcoholic fatty liver disease (NAFLD). Here, we investigate the specific mechanism by which FC induces liver injury in NAFLD and propose a novel therapeutic approach using dihydrotanshinone I...

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Bibliographic Details
Main Authors: Jia‐Wen Shou, Juncai Ma, Xuchu Wang, Xiao‐Xiao Li, Shu‐Cheng Chen, Byung‐Ho Kang, Pang‐Chui Shaw
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
NAFLD
Free cholesterol
ROS
Lysosome
Dihydrotanshinone I
PPARα
Online Access:https://doi.org/10.1002/advs.202406191
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https://doi.org/10.1002/advs.202406191

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