Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s Disease
Atypical perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) occur in most patients with ulcerative colitis but only in a minority of those with Crohn's disease. In a recent st...
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| Format: | Article |
| Language: | English |
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Wiley
1997-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/1997/237085 |
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| author | Hugh J Freeman |
| author_facet | Hugh J Freeman |
| author_sort | Hugh J Freeman |
| collection | DOAJ |
| description | Atypical perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) occur in most patients with ulcerative colitis but only in a minority of those with Crohn's disease. In a recent study from the United States, this serological marker was reported to be present in 100% of Crohn's disease patients with a clinical phenotype of 'left-sided ulcerative colitis' but was not present in patients with 'isolated' small bowel disease. In a previously reported survey from the author's hospital, the p-ANCA status of 247 consecutive patients with Crohn's disease was evaluated, and, of these, 33 Crohn's disease patients were seropositive, including 18 (13.0%) with combined small and large bowel disease, 11 (19.6%) with 'isolated' colorectal disease, and four (4.6%) with 'isolated' small bowel but no detectable colorectal disease. To further evaluate and verify the significance of atypical p-ANCA in these 33 patients, clinical, radiological, endoscopic and histological features were examined. This study confirms that an 'ulcerative colitis-like' clinical phenotype may be seen in most, but not all, serologically positive Crohn's disease patients. Moreover, 'isolated' small bowel disease in the absence of colorectal disease occurs. Detection of atypical p-ANCA in Crohn's disease with different clinical and pathological features provides serological evidence that Crohn's disease is a very heterogeneous disorder. |
| format | Article |
| id | doaj-art-4606eb2323fd4646bd27fe09d7397d92 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 1997-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-4606eb2323fd4646bd27fe09d7397d922025-02-03T00:59:56ZengWileyCanadian Journal of Gastroenterology0835-79001997-01-0111868969310.1155/1997/237085Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s DiseaseHugh J FreemanAtypical perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) occur in most patients with ulcerative colitis but only in a minority of those with Crohn's disease. In a recent study from the United States, this serological marker was reported to be present in 100% of Crohn's disease patients with a clinical phenotype of 'left-sided ulcerative colitis' but was not present in patients with 'isolated' small bowel disease. In a previously reported survey from the author's hospital, the p-ANCA status of 247 consecutive patients with Crohn's disease was evaluated, and, of these, 33 Crohn's disease patients were seropositive, including 18 (13.0%) with combined small and large bowel disease, 11 (19.6%) with 'isolated' colorectal disease, and four (4.6%) with 'isolated' small bowel but no detectable colorectal disease. To further evaluate and verify the significance of atypical p-ANCA in these 33 patients, clinical, radiological, endoscopic and histological features were examined. This study confirms that an 'ulcerative colitis-like' clinical phenotype may be seen in most, but not all, serologically positive Crohn's disease patients. Moreover, 'isolated' small bowel disease in the absence of colorectal disease occurs. Detection of atypical p-ANCA in Crohn's disease with different clinical and pathological features provides serological evidence that Crohn's disease is a very heterogeneous disorder.http://dx.doi.org/10.1155/1997/237085 |
| spellingShingle | Hugh J Freeman Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s Disease Canadian Journal of Gastroenterology |
| title | Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s Disease |
| title_full | Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s Disease |
| title_fullStr | Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s Disease |
| title_full_unstemmed | Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s Disease |
| title_short | Atypical Perinuclear Antineutrophil Cytoplasmic Antibodies in Patients with Crohn’s Disease |
| title_sort | atypical perinuclear antineutrophil cytoplasmic antibodies in patients with crohn s disease |
| url | http://dx.doi.org/10.1155/1997/237085 |
| work_keys_str_mv | AT hughjfreeman atypicalperinuclearantineutrophilcytoplasmicantibodiesinpatientswithcrohnsdisease |