Efficacy of Enterocin S760 in Treatment of Mice with Anthrax Infection Due to Bacillus anthracis M-71
The therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the pept...
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
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| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/396 |
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| author | E. A. Svetoch A. I. Borzilov B. V. Eruslanov O. V. Korobova T. I. Kombarova V. P. Levchuk M. G. Teymurazov Y. G. Stepanshin L. I. Marinin I. A. Dyatlov |
| author_facet | E. A. Svetoch A. I. Borzilov B. V. Eruslanov O. V. Korobova T. I. Kombarova V. P. Levchuk M. G. Teymurazov Y. G. Stepanshin L. I. Marinin I. A. Dyatlov |
| author_sort | E. A. Svetoch |
| collection | DOAJ |
| description | The therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the peptide in a dose of 25 mg/kg for 10 days for prophylactic (1 hour after the contamination) and therapeutic (24 hours after the contamination) purposes prevented or cured the infection in 90-100% of the mice versus the 100-percent lethality in the control (untreated animals). The antimicrobial activity of enterocin S760 against B.anthracis M-71 in vivo correlated with activity in vitro. Enterocin S760 is considered a novel promising antimicrobial for the treatment of grampositive and gramnegative infections. |
| format | Article |
| id | doaj-art-460265bcb27047e4b683a0599df1acc7 |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2020-05-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-460265bcb27047e4b683a0599df1acc72025-08-20T03:59:08ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902020-05-01569-101318395Efficacy of Enterocin S760 in Treatment of Mice with Anthrax Infection Due to Bacillus anthracis M-71E. A. Svetoch0A. I. Borzilov1B. V. Eruslanov2O. V. Korobova3T. I. Kombarova4V. P. Levchuk5M. G. Teymurazov6Y. G. Stepanshin7L. I. Marinin8I. A. Dyatlov9142279, Московская обл., Серпуховский р-н, п. Оболенск142279, Московская обл., Серпуховский р-н, п. Оболенск142279, Московская обл., Серпуховский р-н, п. Оболенск142279, Московская обл., Серпуховский р-н, п. Оболенск142279, Московская обл., Серпуховский р-н, п. Оболенск142279, Московская обл., Серпуховский р-н, п. Оболенск142279, Московская обл., Серпуховский р-н, п. Оболенск142279, Московская обл., Серпуховский р-н, п. Оболенск142279, Московская обл., Серпуховский р-н, п. Оболенск142279, Московская обл., Серпуховский р-н, п. ОболенскThe therapeutic efficacy of enterocin S760, a broad spectrum antimicrobial peptide produced by Enterococcus faecium LWP760 was tested on mice infected with Bacillus anthracis M-71 to induce anthrax (second Tsenkovsky's vaccine). Intraperitoneal four-, two- or one-fold administration of the peptide in a dose of 25 mg/kg for 10 days for prophylactic (1 hour after the contamination) and therapeutic (24 hours after the contamination) purposes prevented or cured the infection in 90-100% of the mice versus the 100-percent lethality in the control (untreated animals). The antimicrobial activity of enterocin S760 against B.anthracis M-71 in vivo correlated with activity in vitro. Enterocin S760 is considered a novel promising antimicrobial for the treatment of grampositive and gramnegative infections.https://www.antibiotics-chemotherapy.ru/jour/article/view/396bacteriocinenterocinantimicrobial activityanthrax |
| spellingShingle | E. A. Svetoch A. I. Borzilov B. V. Eruslanov O. V. Korobova T. I. Kombarova V. P. Levchuk M. G. Teymurazov Y. G. Stepanshin L. I. Marinin I. A. Dyatlov Efficacy of Enterocin S760 in Treatment of Mice with Anthrax Infection Due to Bacillus anthracis M-71 Антибиотики и Химиотерапия bacteriocin enterocin antimicrobial activity anthrax |
| title | Efficacy of Enterocin S760 in Treatment of Mice with Anthrax Infection Due to Bacillus anthracis M-71 |
| title_full | Efficacy of Enterocin S760 in Treatment of Mice with Anthrax Infection Due to Bacillus anthracis M-71 |
| title_fullStr | Efficacy of Enterocin S760 in Treatment of Mice with Anthrax Infection Due to Bacillus anthracis M-71 |
| title_full_unstemmed | Efficacy of Enterocin S760 in Treatment of Mice with Anthrax Infection Due to Bacillus anthracis M-71 |
| title_short | Efficacy of Enterocin S760 in Treatment of Mice with Anthrax Infection Due to Bacillus anthracis M-71 |
| title_sort | efficacy of enterocin s760 in treatment of mice with anthrax infection due to bacillus anthracis m 71 |
| topic | bacteriocin enterocin antimicrobial activity anthrax |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/396 |
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