Correction of Renal Metabolic Disturbances in Acute Profuse Hemorrhage (Experimental Study)
Objective: to comparatively evaluate the efficacy of various blood substitutes used in the correction of renal metabolic disturbances.Materials and methods. Experiments were made on 120 non-inbred male rats. Acute blood loss was simulated, by removing 50% of the volume of circulating blood from the...
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| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2007-12-01
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| Series: | Общая реаниматология |
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| Online Access: | https://www.reanimatology.com/rmt/article/view/880 |
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| author | A. M. Golubev F. A. Tamayeva |
| author_facet | A. M. Golubev F. A. Tamayeva |
| author_sort | A. M. Golubev |
| collection | DOAJ |
| description | Objective: to comparatively evaluate the efficacy of various blood substitutes used in the correction of renal metabolic disturbances.Materials and methods. Experiments were made on 120 non-inbred male rats. Acute blood loss was simulated, by removing 50% of the volume of circulating blood from the animals for 10 min. The experiments lasted 1, 4, 7, 14, and 30 days. The kidneys were histologically and histoenzymatically studied, followed by the quantitative estimation of the rate of histochemical reactions. Morphometric measurements were statistically processed, by using Student’s t-test.Results. Acute profuse blood loss leads to the development of dystrophic changes and the inhibited activity of redox enzymes in the renal glomerular and tubular apparatuses. The multifunctional perfluorocarbon emulsion Perfluorane has a noticeable therapeutic effect in diminishing the manifestations of renal dystrophic and metabolic changes occurring in acute massive blood loss.Conclusion. Experimental results allow the author to recommend perfluorane as a more effective blood-substituting agent to diminish the damaging action of hypoxia developing in acute massive blood loss. |
| format | Article |
| id | doaj-art-45ff553515964cff8c31db4e82ccadc0 |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2007-12-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-45ff553515964cff8c31db4e82ccadc02025-08-20T02:55:52ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102007-12-0136384210.15360/1813-9779-2007-6-38-42880Correction of Renal Metabolic Disturbances in Acute Profuse Hemorrhage (Experimental Study)A. M. Golubev0F. A. Tamayeva1Research Institute of General Reanimatology, Russian Academy of Medical Sciences, MoscowDaghestan State Medical Academy, MakhachkalaObjective: to comparatively evaluate the efficacy of various blood substitutes used in the correction of renal metabolic disturbances.Materials and methods. Experiments were made on 120 non-inbred male rats. Acute blood loss was simulated, by removing 50% of the volume of circulating blood from the animals for 10 min. The experiments lasted 1, 4, 7, 14, and 30 days. The kidneys were histologically and histoenzymatically studied, followed by the quantitative estimation of the rate of histochemical reactions. Morphometric measurements were statistically processed, by using Student’s t-test.Results. Acute profuse blood loss leads to the development of dystrophic changes and the inhibited activity of redox enzymes in the renal glomerular and tubular apparatuses. The multifunctional perfluorocarbon emulsion Perfluorane has a noticeable therapeutic effect in diminishing the manifestations of renal dystrophic and metabolic changes occurring in acute massive blood loss.Conclusion. Experimental results allow the author to recommend perfluorane as a more effective blood-substituting agent to diminish the damaging action of hypoxia developing in acute massive blood loss.https://www.reanimatology.com/rmt/article/view/880acute massive blood losskidneyperfluorane |
| spellingShingle | A. M. Golubev F. A. Tamayeva Correction of Renal Metabolic Disturbances in Acute Profuse Hemorrhage (Experimental Study) Общая реаниматология acute massive blood loss kidney perfluorane |
| title | Correction of Renal Metabolic Disturbances in Acute Profuse Hemorrhage (Experimental Study) |
| title_full | Correction of Renal Metabolic Disturbances in Acute Profuse Hemorrhage (Experimental Study) |
| title_fullStr | Correction of Renal Metabolic Disturbances in Acute Profuse Hemorrhage (Experimental Study) |
| title_full_unstemmed | Correction of Renal Metabolic Disturbances in Acute Profuse Hemorrhage (Experimental Study) |
| title_short | Correction of Renal Metabolic Disturbances in Acute Profuse Hemorrhage (Experimental Study) |
| title_sort | correction of renal metabolic disturbances in acute profuse hemorrhage experimental study |
| topic | acute massive blood loss kidney perfluorane |
| url | https://www.reanimatology.com/rmt/article/view/880 |
| work_keys_str_mv | AT amgolubev correctionofrenalmetabolicdisturbancesinacuteprofusehemorrhageexperimentalstudy AT fatamayeva correctionofrenalmetabolicdisturbancesinacuteprofusehemorrhageexperimentalstudy |