Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-up
Aim. To study the long-term effect of renal denervation (RDN) on left ventricular mass (LVM) and inflammatory markers in resistant hypertensive patients.Material and methods. Forty-one patients with resistant hypertension and 24-h blood pressure (BP) 158,7±15,8/87,3+14,6 mmHg, aged 56,6+10,2 years,...
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| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2021-03-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2678 |
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| author | E. S. Sitkova V. F. Mordovin S. E. Pekarskiy T. M. Ripp T. R. Ryabova А. Yu. Falkovskaya V. A. Lichikaki I. V. Zyubanova A. Е. Baev A. M. Gusakova |
| author_facet | E. S. Sitkova V. F. Mordovin S. E. Pekarskiy T. M. Ripp T. R. Ryabova А. Yu. Falkovskaya V. A. Lichikaki I. V. Zyubanova A. Е. Baev A. M. Gusakova |
| author_sort | E. S. Sitkova |
| collection | DOAJ |
| description | Aim. To study the long-term effect of renal denervation (RDN) on left ventricular mass (LVM) and inflammatory markers in resistant hypertensive patients.Material and methods. Forty-one patients with resistant hypertension and 24-h blood pressure (BP) 158,7±15,8/87,3+14,6 mmHg, aged 56,6+10,2 years, were enrolled in the study and undergone RDN. Mean 24-h BP, left ventricular mass (transthoracic echocardiography), high sensitivity C-reactive protein (hsCRP), interleukin- 1β (IL1β), IL-6, IL-10) and tumor necrosis factor alpha (TNF- α) were assessed at baseline and 2 years after the RDN.Results. A baseline prevalence of left ventricular hypertrophy (LVH) was 90,2%. Two years after RDN LVM and interventricular septum (IVS) decreased significantly (p<0.05 for both). Decrease in myocardial mass (∆LVM >0 g) was documented in 24 patients. The regression of LVM was accompanied by a significant decrease in levels of inflammatory markers — hsCRP by 38,3% (p=0,031), TNF-α by 60,7% (p=0,009), IL- 1β — by 71,1% (p=0,001), and IL-10 by 58,2% (p=0,001). In patients in the absence of LVM regression only TNF-α decreased significantly (-68,8%, p=0,001). There was no correlation between changes of LVM and the inflammatory markers at 24 months after RDN.Conclusion. The RDN in RH patients may have long-term cardioprotective effect in terms of significant regress of LVH, which may be partly attributed to the regress in systemic or myocardial inflammation. |
| format | Article |
| id | doaj-art-45f95322aba4479fa14168049fd9830f |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2021-03-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-45f95322aba4479fa14168049fd9830f2025-08-20T03:18:46Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252021-03-0120210.15829/1728-8800-2021-26782246Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-upE. S. Sitkova0V. F. Mordovin1S. E. Pekarskiy2T. M. Ripp3T. R. Ryabova4А. Yu. Falkovskaya5V. A. Lichikaki6I. V. Zyubanova7A. Е. Baev8A. M. Gusakova9Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesCardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of SciencesAim. To study the long-term effect of renal denervation (RDN) on left ventricular mass (LVM) and inflammatory markers in resistant hypertensive patients.Material and methods. Forty-one patients with resistant hypertension and 24-h blood pressure (BP) 158,7±15,8/87,3+14,6 mmHg, aged 56,6+10,2 years, were enrolled in the study and undergone RDN. Mean 24-h BP, left ventricular mass (transthoracic echocardiography), high sensitivity C-reactive protein (hsCRP), interleukin- 1β (IL1β), IL-6, IL-10) and tumor necrosis factor alpha (TNF- α) were assessed at baseline and 2 years after the RDN.Results. A baseline prevalence of left ventricular hypertrophy (LVH) was 90,2%. Two years after RDN LVM and interventricular septum (IVS) decreased significantly (p<0.05 for both). Decrease in myocardial mass (∆LVM >0 g) was documented in 24 patients. The regression of LVM was accompanied by a significant decrease in levels of inflammatory markers — hsCRP by 38,3% (p=0,031), TNF-α by 60,7% (p=0,009), IL- 1β — by 71,1% (p=0,001), and IL-10 by 58,2% (p=0,001). In patients in the absence of LVM regression only TNF-α decreased significantly (-68,8%, p=0,001). There was no correlation between changes of LVM and the inflammatory markers at 24 months after RDN.Conclusion. The RDN in RH patients may have long-term cardioprotective effect in terms of significant regress of LVH, which may be partly attributed to the regress in systemic or myocardial inflammation.https://cardiovascular.elpub.ru/jour/article/view/2678resistant hypertensioncardioprotective efficacyleft ventricular hypertrophyrenal denervationinflammation |
| spellingShingle | E. S. Sitkova V. F. Mordovin S. E. Pekarskiy T. M. Ripp T. R. Ryabova А. Yu. Falkovskaya V. A. Lichikaki I. V. Zyubanova A. Е. Baev A. M. Gusakova Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-up Кардиоваскулярная терапия и профилактика resistant hypertension cardioprotective efficacy left ventricular hypertrophy renal denervation inflammation |
| title | Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-up |
| title_full | Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-up |
| title_fullStr | Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-up |
| title_full_unstemmed | Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-up |
| title_short | Positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass. 24-months follow-up |
| title_sort | positive effects of renal denervation on markers of cardiovascular inflammation and left ventricular mass 24 months follow up |
| topic | resistant hypertension cardioprotective efficacy left ventricular hypertrophy renal denervation inflammation |
| url | https://cardiovascular.elpub.ru/jour/article/view/2678 |
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