Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review
Background. Systemic sclerosis (SSc) is a chronic multisystem autoimmune condition defined by a complex pathobiology, comprising excessive fibrosis of skin and internal organs, peripheral vasculopathy with endothelial cell dysfunction, inadequate vascular repair and neovascularization, and aberrant...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2021/9782994 |
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| author | Alexandra-Diana Diaconu Iustina Ostafie Alexandr Ceasovschih Victorița Șorodoc Cătălina Lionte Codrina Ancuța Laurențiu Șorodoc |
| author_facet | Alexandra-Diana Diaconu Iustina Ostafie Alexandr Ceasovschih Victorița Șorodoc Cătălina Lionte Codrina Ancuța Laurențiu Șorodoc |
| author_sort | Alexandra-Diana Diaconu |
| collection | DOAJ |
| description | Background. Systemic sclerosis (SSc) is a chronic multisystem autoimmune condition defined by a complex pathobiology, comprising excessive fibrosis of skin and internal organs, peripheral vasculopathy with endothelial cell dysfunction, inadequate vascular repair and neovascularization, and aberrant immunity. Vitamin D is a steroid hormone with pleiotropic effects beyond its traditional role in calcium and bone homeostasis. Since vitamin D has immunomodulatory, cardioprotective, and antifibrotic properties, it could potentially interfere with SSc pathogenesis. Suboptimal vitamin D levels are classically recognized in scleroderma, irrespective of clinical and serological phenotype. Aim. This systematic review is aimed at investigating and clarifying the role of vitamin D in SSc and emphasizing the association of vitamin D status with different clinical settings. Methods and Results. A systematic online search was performed, using PubMed databases to collect articles on the topic of vitamin D in SSc. The final analysis included 40 eligible articles. Conclusions. Hypovitaminosis D is common in SSc patients and could be associated with clinical and serologic patterns of the disease. Intervention for low serum vitamin D levels in SSc pathogenesis remains controversial, as well as the significance of vitamin D supplementation in such patients. |
| format | Article |
| id | doaj-art-45f3b562f6214a6fb91dbf8a6d926f8a |
| institution | OA Journals |
| issn | 2314-7156 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-45f3b562f6214a6fb91dbf8a6d926f8a2025-08-20T02:37:49ZengWileyJournal of Immunology Research2314-71562021-01-01202110.1155/2021/9782994Role of Vitamin D in Systemic Sclerosis: A Systematic Literature ReviewAlexandra-Diana Diaconu0Iustina Ostafie1Alexandr Ceasovschih2Victorița Șorodoc3Cătălina Lionte4Codrina Ancuța5Laurențiu Șorodoc62nd Rheumatology Department2nd Rheumatology Department2nd Internal Medicine Department2nd Internal Medicine Department2nd Internal Medicine Department2nd Rheumatology Department2nd Internal Medicine DepartmentBackground. Systemic sclerosis (SSc) is a chronic multisystem autoimmune condition defined by a complex pathobiology, comprising excessive fibrosis of skin and internal organs, peripheral vasculopathy with endothelial cell dysfunction, inadequate vascular repair and neovascularization, and aberrant immunity. Vitamin D is a steroid hormone with pleiotropic effects beyond its traditional role in calcium and bone homeostasis. Since vitamin D has immunomodulatory, cardioprotective, and antifibrotic properties, it could potentially interfere with SSc pathogenesis. Suboptimal vitamin D levels are classically recognized in scleroderma, irrespective of clinical and serological phenotype. Aim. This systematic review is aimed at investigating and clarifying the role of vitamin D in SSc and emphasizing the association of vitamin D status with different clinical settings. Methods and Results. A systematic online search was performed, using PubMed databases to collect articles on the topic of vitamin D in SSc. The final analysis included 40 eligible articles. Conclusions. Hypovitaminosis D is common in SSc patients and could be associated with clinical and serologic patterns of the disease. Intervention for low serum vitamin D levels in SSc pathogenesis remains controversial, as well as the significance of vitamin D supplementation in such patients.http://dx.doi.org/10.1155/2021/9782994 |
| spellingShingle | Alexandra-Diana Diaconu Iustina Ostafie Alexandr Ceasovschih Victorița Șorodoc Cătălina Lionte Codrina Ancuța Laurențiu Șorodoc Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review Journal of Immunology Research |
| title | Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review |
| title_full | Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review |
| title_fullStr | Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review |
| title_full_unstemmed | Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review |
| title_short | Role of Vitamin D in Systemic Sclerosis: A Systematic Literature Review |
| title_sort | role of vitamin d in systemic sclerosis a systematic literature review |
| url | http://dx.doi.org/10.1155/2021/9782994 |
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