Middle lobe tumors and lymphovascular invasion as independent predictors of recurrence-free survival in stage I NSCLC
Abstract Background Recurrence and metastases are prevalent in lung cancer, contributing to a concerning rate of treatment failure. As a result, there is a pressing need for multivariate analyses of prognostic utility in non-small cell lung cancer (NSCLC). This study reports on the factors influenci...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-025-03560-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850026143423397888 |
|---|---|
| author | Mustafa Akyıl Serkan Bayram |
| author_facet | Mustafa Akyıl Serkan Bayram |
| author_sort | Mustafa Akyıl |
| collection | DOAJ |
| description | Abstract Background Recurrence and metastases are prevalent in lung cancer, contributing to a concerning rate of treatment failure. As a result, there is a pressing need for multivariate analyses of prognostic utility in non-small cell lung cancer (NSCLC). This study reports on the factors influencing metastasis and recurrence-free survival (RFS) in patients with clinical stage I NSCLC who have undergone anatomic lung resection. Methods This study included patients diagnosed with stage I NSCLC who received surgical treatment at our institution between January 2016 and December 2022. A careful examination was conducted of the patients’ demographic, clinical, radiological, and histopathological data. The prognostic value of the recorded parameters was assessed according to recurrence and/or metastasis, considering RFS during follow-up assessments. Results Among the 616 patients included in this study, the average age was 63 ± 8.9 years, with 506 (82.1%) of patients being male. During a median follow-up period of 50.4 ± 23.7 months (ranging from 1 to 89 months), 79 patients (12.8%) experienced recurrence or metastasis, while 41 patients (6.7%) died. Multivariate analysis showed no significant differences (p > 0.05) regarding recurrence or metastasis development when considering demographic characteristics, tumor size, operation forms, histopathologic types involved, perineural and visceral pleural invasion status, and aspects of oncological treatment. Conversely, the presence of lymphovascular invasion (p < 0.003) and tumor localization in the middle node (p < 0.045) emerged as significant predictors of RFS. Conclusion In patients with early-stage NSCLC, the presence of lymphovascular invasion and localization of the tumor in the middle lobe are independent predictors of RFS. |
| format | Article |
| id | doaj-art-45f16e33607f49548b0b1f95acdaabc5 |
| institution | DOAJ |
| issn | 1471-2466 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj-art-45f16e33607f49548b0b1f95acdaabc52025-08-20T03:00:37ZengBMCBMC Pulmonary Medicine1471-24662025-02-012511910.1186/s12890-025-03560-wMiddle lobe tumors and lymphovascular invasion as independent predictors of recurrence-free survival in stage I NSCLCMustafa Akyıl0Serkan Bayram1Department of Thoracic Surgery, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research HospitalDepartment of Thoracic Surgery, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research HospitalAbstract Background Recurrence and metastases are prevalent in lung cancer, contributing to a concerning rate of treatment failure. As a result, there is a pressing need for multivariate analyses of prognostic utility in non-small cell lung cancer (NSCLC). This study reports on the factors influencing metastasis and recurrence-free survival (RFS) in patients with clinical stage I NSCLC who have undergone anatomic lung resection. Methods This study included patients diagnosed with stage I NSCLC who received surgical treatment at our institution between January 2016 and December 2022. A careful examination was conducted of the patients’ demographic, clinical, radiological, and histopathological data. The prognostic value of the recorded parameters was assessed according to recurrence and/or metastasis, considering RFS during follow-up assessments. Results Among the 616 patients included in this study, the average age was 63 ± 8.9 years, with 506 (82.1%) of patients being male. During a median follow-up period of 50.4 ± 23.7 months (ranging from 1 to 89 months), 79 patients (12.8%) experienced recurrence or metastasis, while 41 patients (6.7%) died. Multivariate analysis showed no significant differences (p > 0.05) regarding recurrence or metastasis development when considering demographic characteristics, tumor size, operation forms, histopathologic types involved, perineural and visceral pleural invasion status, and aspects of oncological treatment. Conversely, the presence of lymphovascular invasion (p < 0.003) and tumor localization in the middle node (p < 0.045) emerged as significant predictors of RFS. Conclusion In patients with early-stage NSCLC, the presence of lymphovascular invasion and localization of the tumor in the middle lobe are independent predictors of RFS.https://doi.org/10.1186/s12890-025-03560-wLung cancerLymphovascular invasionMiddle lobe |
| spellingShingle | Mustafa Akyıl Serkan Bayram Middle lobe tumors and lymphovascular invasion as independent predictors of recurrence-free survival in stage I NSCLC BMC Pulmonary Medicine Lung cancer Lymphovascular invasion Middle lobe |
| title | Middle lobe tumors and lymphovascular invasion as independent predictors of recurrence-free survival in stage I NSCLC |
| title_full | Middle lobe tumors and lymphovascular invasion as independent predictors of recurrence-free survival in stage I NSCLC |
| title_fullStr | Middle lobe tumors and lymphovascular invasion as independent predictors of recurrence-free survival in stage I NSCLC |
| title_full_unstemmed | Middle lobe tumors and lymphovascular invasion as independent predictors of recurrence-free survival in stage I NSCLC |
| title_short | Middle lobe tumors and lymphovascular invasion as independent predictors of recurrence-free survival in stage I NSCLC |
| title_sort | middle lobe tumors and lymphovascular invasion as independent predictors of recurrence free survival in stage i nsclc |
| topic | Lung cancer Lymphovascular invasion Middle lobe |
| url | https://doi.org/10.1186/s12890-025-03560-w |
| work_keys_str_mv | AT mustafaakyıl middlelobetumorsandlymphovascularinvasionasindependentpredictorsofrecurrencefreesurvivalinstageinsclc AT serkanbayram middlelobetumorsandlymphovascularinvasionasindependentpredictorsofrecurrencefreesurvivalinstageinsclc |