Use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia: report of two cases and review of the literature
Hypercalcemia is a rare complication of malignancy in children. We present two children, one of whom is the youngest reported, with CALLA+ B-cell acute lymphoblastic leukemia (ALL) who developed hypercalcemia at the time of diagnosis and were treated with relatively low-dose (0.5 mg/kg) intra...
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| Format: | Article |
| Language: | English |
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Hacettepe University Institute of Child Health
2006-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/2638 |
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| _version_ | 1850236658377555968 |
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| author | Nesibe Andiran Ayfer Alikaşifoğlu Serhan Küpeli Sevgi Yetgin |
| author_facet | Nesibe Andiran Ayfer Alikaşifoğlu Serhan Küpeli Sevgi Yetgin |
| author_sort | Nesibe Andiran |
| collection | DOAJ |
| description |
Hypercalcemia is a rare complication of malignancy in children. We present two children, one of whom is the youngest reported, with CALLA+ B-cell acute lymphoblastic leukemia (ALL) who developed hypercalcemia at the time of diagnosis and were treated with relatively low-dose (0.5 mg/kg) intravenous pamidronate successive to conventional therapy. No major side effects were encountered except transient hypocalcemia and hypophosphatemia, which were easily managed by replacement therapy. Bisphosphonate therapy was found to be beneficial for the treatment of resistant hypercalcemia associated with ALL, even at relatively low doses.
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| format | Article |
| id | doaj-art-45efdc6fad1e47bf956ba9b10d4a460e |
| institution | OA Journals |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2006-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-45efdc6fad1e47bf956ba9b10d4a460e2025-08-20T02:01:54ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212006-07-01483Use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia: report of two cases and review of the literatureNesibe Andiran0Ayfer AlikaşifoğluSerhan KüpeliSevgi YetginDivision of Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey. Hypercalcemia is a rare complication of malignancy in children. We present two children, one of whom is the youngest reported, with CALLA+ B-cell acute lymphoblastic leukemia (ALL) who developed hypercalcemia at the time of diagnosis and were treated with relatively low-dose (0.5 mg/kg) intravenous pamidronate successive to conventional therapy. No major side effects were encountered except transient hypocalcemia and hypophosphatemia, which were easily managed by replacement therapy. Bisphosphonate therapy was found to be beneficial for the treatment of resistant hypercalcemia associated with ALL, even at relatively low doses. https://turkjpediatr.org/article/view/2638 |
| spellingShingle | Nesibe Andiran Ayfer Alikaşifoğlu Serhan Küpeli Sevgi Yetgin Use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia: report of two cases and review of the literature The Turkish Journal of Pediatrics |
| title | Use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia: report of two cases and review of the literature |
| title_full | Use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia: report of two cases and review of the literature |
| title_fullStr | Use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia: report of two cases and review of the literature |
| title_full_unstemmed | Use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia: report of two cases and review of the literature |
| title_short | Use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia: report of two cases and review of the literature |
| title_sort | use of bisphosphonates for resistant hypercalcemia in children with acute lymphoblastic leukemia report of two cases and review of the literature |
| url | https://turkjpediatr.org/article/view/2638 |
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