Genomic and transcriptomic profiling of radioresistant prostate and head and neck cancers implicate a BAHD1-dependent modification of DNA damage at the heterochromatin

Genomic and transcriptomic profiling of radioresistant prostate and head and neck cancers implicate a BAHD1-dependent modification of DNA damage at the heterochromatin

Abstract Radiotherapy is an integral modality in treating human cancers, but radioresistance remains a clinical challenge due to the involvement of multiple intrinsic cellular and extrinsic tumour microenvironment factors that govern radiosensitivity. To study the intrinsic factors that are associat...

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Main Authors: Chaw Yee Beh, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Kah Min Tan, Dennis Jun Jie Poon, Pek Lim Chu, Dewi Susanti, Pei Ling Tai, Monica Ryu, James Proudfoot, Eugenia Li Ling Yeo, Khee Chee Soo, Melvin L. K. Chua
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07316-y
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