Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age
Prenatal and childhood bisphenol A (BPA) exposures are known to negatively affect neurodevelopment, but the impact of exposure during the infancy period remains unclear. This study aimed to investigate BPA exposure at 1 and 6 months of age and its correlation with neurodevelopmental scores at 2 year...
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325012412 |
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| author | Ying Zhao Yanbin Ye Huifang Lin Xiaolin Ruan Yong Guo Jieling Wu |
| author_facet | Ying Zhao Yanbin Ye Huifang Lin Xiaolin Ruan Yong Guo Jieling Wu |
| author_sort | Ying Zhao |
| collection | DOAJ |
| description | Prenatal and childhood bisphenol A (BPA) exposures are known to negatively affect neurodevelopment, but the impact of exposure during the infancy period remains unclear. This study aimed to investigate BPA exposure at 1 and 6 months of age and its correlation with neurodevelopmental scores at 2 years of age, focusing on age-specific effects and potential sex differences. In the cohort study conducted from May 2021 to December 2023, urine samples were collected from infants at 1 and 6 months, followed by neurodevelopmental assessments at 2 years of age. Of the 240 and 210 urine samples collected at 1 and 6 months, urinary BPA was detected via liquid chromatographytandem mass spectrometry in 93.7 and 93.8 %, with median concentrations of 2.79 and 4.04 μg/L, respectively. At the 1-month assessment, no statistically significant associations were observed between urinary BPA concentrations and any neurodevelopmental outcomes in either male or female infants (all adjusted P > 0.05). However, at the 6-month assessment, significant inverse associations were identified exclusively in female infants. Specifically, higher urinary BPA concentrations at 6 months were independently associated with lower scores in the gross motor domain (adjusted β = −3.33; 95 % CI: −6.36, −0.30; P = 0.032), adaptive behavior domain (adjusted β = −5.01; 95 % CI: −9.28, −0.74; P = 0.022), personal-social skills (adjusted β = −6.12; 95 % CI: −11.29, −0.94; P = 0.021), and the total neurodevelopmental score (adjusted β = −4.21; 95 % CI: −8.02, −0.40; P = 0.031) after controlling for relevant confounders. In contrast, no significant associations were detected between 6-month BPA concentrations and neurodevelopmental outcomes in male infants (all adjusted P > 0.05). Our study identified neurodevelopmental effects of BPA as specific to both exposure timing and infant sex, highlighted by the finding that exposure at 6 months was negatively associated with neurodevelopmental scores in females. |
| format | Article |
| id | doaj-art-45ea5f460b7f4d17ac70fd1c4aefcffb |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-45ea5f460b7f4d17ac70fd1c4aefcffb2025-08-22T04:54:45ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130311889610.1016/j.ecoenv.2025.118896Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of ageYing Zhao0Yanbin Ye1Huifang Lin2Xiaolin Ruan3Yong Guo4Jieling Wu5Department of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou 511442, ChinaDepartment of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou 511442, ChinaDepartment of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou 511442, ChinaClinical Mass Spectrometry Laboratory, Guangdong Women and Children Hospital, Guangzhou 511442, ChinaDepartment of Health Care, Guangdong Women and Children Hospital, Guangzhou 511442, China; Corresponding authors.Department of Children’s Health Care, Guangdong Women and Children Hospital, Guangzhou 511442, China; Corresponding authors.Prenatal and childhood bisphenol A (BPA) exposures are known to negatively affect neurodevelopment, but the impact of exposure during the infancy period remains unclear. This study aimed to investigate BPA exposure at 1 and 6 months of age and its correlation with neurodevelopmental scores at 2 years of age, focusing on age-specific effects and potential sex differences. In the cohort study conducted from May 2021 to December 2023, urine samples were collected from infants at 1 and 6 months, followed by neurodevelopmental assessments at 2 years of age. Of the 240 and 210 urine samples collected at 1 and 6 months, urinary BPA was detected via liquid chromatographytandem mass spectrometry in 93.7 and 93.8 %, with median concentrations of 2.79 and 4.04 μg/L, respectively. At the 1-month assessment, no statistically significant associations were observed between urinary BPA concentrations and any neurodevelopmental outcomes in either male or female infants (all adjusted P > 0.05). However, at the 6-month assessment, significant inverse associations were identified exclusively in female infants. Specifically, higher urinary BPA concentrations at 6 months were independently associated with lower scores in the gross motor domain (adjusted β = −3.33; 95 % CI: −6.36, −0.30; P = 0.032), adaptive behavior domain (adjusted β = −5.01; 95 % CI: −9.28, −0.74; P = 0.022), personal-social skills (adjusted β = −6.12; 95 % CI: −11.29, −0.94; P = 0.021), and the total neurodevelopmental score (adjusted β = −4.21; 95 % CI: −8.02, −0.40; P = 0.031) after controlling for relevant confounders. In contrast, no significant associations were detected between 6-month BPA concentrations and neurodevelopmental outcomes in male infants (all adjusted P > 0.05). Our study identified neurodevelopmental effects of BPA as specific to both exposure timing and infant sex, highlighted by the finding that exposure at 6 months was negatively associated with neurodevelopmental scores in females.http://www.sciencedirect.com/science/article/pii/S0147651325012412Bisphenol AChildNeurodevelopmentBehavior |
| spellingShingle | Ying Zhao Yanbin Ye Huifang Lin Xiaolin Ruan Yong Guo Jieling Wu Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age Ecotoxicology and Environmental Safety Bisphenol A Child Neurodevelopment Behavior |
| title | Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age |
| title_full | Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age |
| title_fullStr | Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age |
| title_full_unstemmed | Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age |
| title_short | Infant urinary bisphenol A concentrations in relation to child neurodevelopment at 2 years of age |
| title_sort | infant urinary bisphenol a concentrations in relation to child neurodevelopment at 2 years of age |
| topic | Bisphenol A Child Neurodevelopment Behavior |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325012412 |
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