The Effects of Almond Oil, Walnut Oil and Corn Oil on Histopathology of the Heart, Aorta and Testes in L-NAME-induced Hypertensive Rats
Introduction: Chronic hypertension is a serious physiological condition that develops histopathological abnormalities such as remodelling, hypertrophy in heart muscle and vasoconstriction of blood vessels. The aim of the study was to determine the impact of almond, walnut and corn oils on remodellin...
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Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Advances in Human Biology |
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| Online Access: | https://journals.lww.com/10.4103/aihb.aihb_61_24 |
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| author | Jamal Kareem Shakor Saman Huseein Mohammed Halgord Ali M Farag Ridha H Hussein Hardi Rafat Baqi |
| author_facet | Jamal Kareem Shakor Saman Huseein Mohammed Halgord Ali M Farag Ridha H Hussein Hardi Rafat Baqi |
| author_sort | Jamal Kareem Shakor |
| collection | DOAJ |
| description | Introduction:
Chronic hypertension is a serious physiological condition that develops histopathological abnormalities such as remodelling, hypertrophy in heart muscle and vasoconstriction of blood vessels. The aim of the study was to determine the impact of almond, walnut and corn oils on remodelling and hypertrophy of the heart, aorta and testicles in high blood pressure (BP)-bearing rats.
Materials and Methods:
Twenty-five adult male albino rats (Rattus norvegicus) weighing 200–250 g were used. Rats were divided into 5 groups, with 5 rats in each group, as the following: Group first: normal control: standard rat chow and tap water ad libitum; Group 2: hypertension induced by L-NAME (model): This group received L-NAME (40 mg/kg/day) orally; Group 3: model + walnut oil, received almond oil (3 ml/kg) for 3 weeks; Group 4: model + almond oil, received walnut oil (3 ml/kg) for 3 weeks and Group 5: mode + corn oil, received corn oil (3 ml/kg) for 3 weeks. The experiment took 28 days, BP was recorded each week and then the animals were sacrificed under the effects of ketamin-xylazine anaesthesia by cervical dislocation. Histopathological slices were taken from the whole heart, aorta and testes using the standard method. The mean BP for each group was presented in the table, and t-test was used for statistical analysis. Histopathological results for each group are shown in the figures.
Results:
In contrast to almond oil, walnut oil and corn oil have significantly reduced BP (157.9 ± 4.490 mmHg) to (140.1 ± 3.068 mmHg) but not to the control level (130.7 ± 2.605). Walnut and corn oil could prevent tunica media thickness in the aortic, remodelling and hypertrophy in cardiac muscle and protect the architecture of spermatogenesis tissue in seminiferous tubules of testicle. Almond-treated groups showed no improvement in histopathological changes when compared with the model in aorta, cardiac muscle and testicle.
Conclusion:
Unlike almond oil, corn and walnut oil can reduce high BP induced by L-NAME and alleviate the histopathological changes that occur as the result of hypertension, such as aortic wall thickness and myocadiac hypertrophy. |
| format | Article |
| id | doaj-art-45e9e4f128fd4d4dba6b0642b466d91c |
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| issn | 2321-8568 2348-4691 |
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| publishDate | 2025-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Advances in Human Biology |
| spelling | doaj-art-45e9e4f128fd4d4dba6b0642b466d91c2025-08-20T02:05:20ZengWolters Kluwer Medknow PublicationsAdvances in Human Biology2321-85682348-46912025-04-0115226126610.4103/aihb.aihb_61_24The Effects of Almond Oil, Walnut Oil and Corn Oil on Histopathology of the Heart, Aorta and Testes in L-NAME-induced Hypertensive RatsJamal Kareem ShakorSaman Huseein MohammedHalgord Ali M FaragRidha H HusseinHardi Rafat BaqiIntroduction: Chronic hypertension is a serious physiological condition that develops histopathological abnormalities such as remodelling, hypertrophy in heart muscle and vasoconstriction of blood vessels. The aim of the study was to determine the impact of almond, walnut and corn oils on remodelling and hypertrophy of the heart, aorta and testicles in high blood pressure (BP)-bearing rats. Materials and Methods: Twenty-five adult male albino rats (Rattus norvegicus) weighing 200–250 g were used. Rats were divided into 5 groups, with 5 rats in each group, as the following: Group first: normal control: standard rat chow and tap water ad libitum; Group 2: hypertension induced by L-NAME (model): This group received L-NAME (40 mg/kg/day) orally; Group 3: model + walnut oil, received almond oil (3 ml/kg) for 3 weeks; Group 4: model + almond oil, received walnut oil (3 ml/kg) for 3 weeks and Group 5: mode + corn oil, received corn oil (3 ml/kg) for 3 weeks. The experiment took 28 days, BP was recorded each week and then the animals were sacrificed under the effects of ketamin-xylazine anaesthesia by cervical dislocation. Histopathological slices were taken from the whole heart, aorta and testes using the standard method. The mean BP for each group was presented in the table, and t-test was used for statistical analysis. Histopathological results for each group are shown in the figures. Results: In contrast to almond oil, walnut oil and corn oil have significantly reduced BP (157.9 ± 4.490 mmHg) to (140.1 ± 3.068 mmHg) but not to the control level (130.7 ± 2.605). Walnut and corn oil could prevent tunica media thickness in the aortic, remodelling and hypertrophy in cardiac muscle and protect the architecture of spermatogenesis tissue in seminiferous tubules of testicle. Almond-treated groups showed no improvement in histopathological changes when compared with the model in aorta, cardiac muscle and testicle. Conclusion: Unlike almond oil, corn and walnut oil can reduce high BP induced by L-NAME and alleviate the histopathological changes that occur as the result of hypertension, such as aortic wall thickness and myocadiac hypertrophy.https://journals.lww.com/10.4103/aihb.aihb_61_24almond oilanimal modelcorn oilhistopathology changeshypertensionwalnut oil |
| spellingShingle | Jamal Kareem Shakor Saman Huseein Mohammed Halgord Ali M Farag Ridha H Hussein Hardi Rafat Baqi The Effects of Almond Oil, Walnut Oil and Corn Oil on Histopathology of the Heart, Aorta and Testes in L-NAME-induced Hypertensive Rats Advances in Human Biology almond oil animal model corn oil histopathology changes hypertension walnut oil |
| title | The Effects of Almond Oil, Walnut Oil and Corn Oil on Histopathology of the Heart, Aorta and Testes in L-NAME-induced Hypertensive Rats |
| title_full | The Effects of Almond Oil, Walnut Oil and Corn Oil on Histopathology of the Heart, Aorta and Testes in L-NAME-induced Hypertensive Rats |
| title_fullStr | The Effects of Almond Oil, Walnut Oil and Corn Oil on Histopathology of the Heart, Aorta and Testes in L-NAME-induced Hypertensive Rats |
| title_full_unstemmed | The Effects of Almond Oil, Walnut Oil and Corn Oil on Histopathology of the Heart, Aorta and Testes in L-NAME-induced Hypertensive Rats |
| title_short | The Effects of Almond Oil, Walnut Oil and Corn Oil on Histopathology of the Heart, Aorta and Testes in L-NAME-induced Hypertensive Rats |
| title_sort | effects of almond oil walnut oil and corn oil on histopathology of the heart aorta and testes in l name induced hypertensive rats |
| topic | almond oil animal model corn oil histopathology changes hypertension walnut oil |
| url | https://journals.lww.com/10.4103/aihb.aihb_61_24 |
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