Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression Syndromes
Lumbar disc herniation (LDH) induced nerve compression syndromes have been a prevalent problem with complex neural mechanisms. Changes in distributed brain areas are involved in the occurrence and persistence of syndromes. The present study aimed to investigate the changes of brain functional networ...
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Wiley
2022-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2022/7912410 |
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| author | Yan-Peng Zhang Guang-Hui Hong Chuan-Yin Zhang |
| author_facet | Yan-Peng Zhang Guang-Hui Hong Chuan-Yin Zhang |
| author_sort | Yan-Peng Zhang |
| collection | DOAJ |
| description | Lumbar disc herniation (LDH) induced nerve compression syndromes have been a prevalent problem with complex neural mechanisms. Changes in distributed brain areas are involved in the occurrence and persistence of syndromes. The present study aimed to investigate the changes of brain functional network in LDH patients with chronic sciatica using graph theory analysis. A total of thirty LDH adults presenting L4 and/or L5 root (s) compression syndromes (LDH group) and thirty age-, sex-, BMI- and education-matched healthy control (HC group) were recruited for functional MRI scan. Whole-brain functional network was constructed for each participant using Pearson’s correlation. Global and nodal properties were calculated and compared between two groups, including small-worldness index, clustering coefficient, characteristic path length, degree centrality (DC), betweenness centrality (BC) and nodal efficiency. Both LDH and HC groups showed small-world architecture in the functional network of brain. However, LDH group showed that nodal centralities (DC, BC and nodal efficiency) increased in opercular part of inferior frontal gyrus; and decreased in orbital part of inferior frontal gyrus, lingual cortex and inferior occipital gyrus. The DC and efficiency in the right inferior occipital gyrus were negatively related with the Oswestry Disability Index in LDH group. In conclusion, the LDH-related chronic sciatica syndromes may induce regional brain alterations involving self-referential, emotional responses and pain regulation functions. But the whole-brain small-world architecture was not significantly disturbed. It may provide new insights into LDH patients with radicular symptoms from new perspectives. |
| format | Article |
| id | doaj-art-45e286ba05e04c5f9c6fb7e8cdc27a25 |
| institution | DOAJ |
| issn | 1687-5443 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
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| series | Neural Plasticity |
| spelling | doaj-art-45e286ba05e04c5f9c6fb7e8cdc27a252025-08-20T02:39:19ZengWileyNeural Plasticity1687-54432022-01-01202210.1155/2022/7912410Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression SyndromesYan-Peng Zhang0Guang-Hui Hong1Chuan-Yin Zhang2Department of OrthopedicsDepartment of OrthopedicsDepartment of OrthopedicsLumbar disc herniation (LDH) induced nerve compression syndromes have been a prevalent problem with complex neural mechanisms. Changes in distributed brain areas are involved in the occurrence and persistence of syndromes. The present study aimed to investigate the changes of brain functional network in LDH patients with chronic sciatica using graph theory analysis. A total of thirty LDH adults presenting L4 and/or L5 root (s) compression syndromes (LDH group) and thirty age-, sex-, BMI- and education-matched healthy control (HC group) were recruited for functional MRI scan. Whole-brain functional network was constructed for each participant using Pearson’s correlation. Global and nodal properties were calculated and compared between two groups, including small-worldness index, clustering coefficient, characteristic path length, degree centrality (DC), betweenness centrality (BC) and nodal efficiency. Both LDH and HC groups showed small-world architecture in the functional network of brain. However, LDH group showed that nodal centralities (DC, BC and nodal efficiency) increased in opercular part of inferior frontal gyrus; and decreased in orbital part of inferior frontal gyrus, lingual cortex and inferior occipital gyrus. The DC and efficiency in the right inferior occipital gyrus were negatively related with the Oswestry Disability Index in LDH group. In conclusion, the LDH-related chronic sciatica syndromes may induce regional brain alterations involving self-referential, emotional responses and pain regulation functions. But the whole-brain small-world architecture was not significantly disturbed. It may provide new insights into LDH patients with radicular symptoms from new perspectives.http://dx.doi.org/10.1155/2022/7912410 |
| spellingShingle | Yan-Peng Zhang Guang-Hui Hong Chuan-Yin Zhang Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression Syndromes Neural Plasticity |
| title | Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression Syndromes |
| title_full | Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression Syndromes |
| title_fullStr | Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression Syndromes |
| title_full_unstemmed | Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression Syndromes |
| title_short | Brain Network Changes in Lumbar Disc Herniation Induced Chronic Nerve Roots Compression Syndromes |
| title_sort | brain network changes in lumbar disc herniation induced chronic nerve roots compression syndromes |
| url | http://dx.doi.org/10.1155/2022/7912410 |
| work_keys_str_mv | AT yanpengzhang brainnetworkchangesinlumbardischerniationinducedchronicnerverootscompressionsyndromes AT guanghuihong brainnetworkchangesinlumbardischerniationinducedchronicnerverootscompressionsyndromes AT chuanyinzhang brainnetworkchangesinlumbardischerniationinducedchronicnerverootscompressionsyndromes |