Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy
ABSTRACT Background Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive dysfunction in the elderly, and frequently coexists with Alzheimer's disease and tau pathology. Dual‐phase 11C‐PiB PET detects amyloid deposition and cerebral perfusion changes...
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Wiley
2025-05-01
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| Series: | Annals of Clinical and Translational Neurology |
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| Online Access: | https://doi.org/10.1002/acn3.70021 |
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| author | Meng‐Ting Chiang Chia‐Ju Liu Bo‐Ching Lee Ruoh‐Fang Yen Hsin‐Hsi Tsai |
| author_facet | Meng‐Ting Chiang Chia‐Ju Liu Bo‐Ching Lee Ruoh‐Fang Yen Hsin‐Hsi Tsai |
| author_sort | Meng‐Ting Chiang |
| collection | DOAJ |
| description | ABSTRACT Background Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive dysfunction in the elderly, and frequently coexists with Alzheimer's disease and tau pathology. Dual‐phase 11C‐PiB PET detects amyloid deposition and cerebral perfusion changes and may have diagnostic value for identifying tau in CAA. Methods We prospectively enrolled patients with probable CAA for dynamic PiB and AV1451 scans. We compared early‐phase (0–6 min after tracer injection) and late‐phase (40–70 min) PiB PET between the tau(+) and tau(−) groups (based on AV1451 PET) and investigated their diagnostic values for detecting tau. Results CAA/tau(+) had lower early‐phase temporal PiB uptake than CAA/tau(−) (p = 0.014) and higher late‐phase uptake in the whole cortex and temporal and parietal lobes (all p < 0.05). Early‐phase temporal PiB SUVR correlated with tau burden (r = −0.34, p = 0.038). Using Youden's cut‐off, early‐phase and late‐phase PET had sensitivities of 55% and 80% and specificities of 85% and 65% for detecting tau, respectively. Combining early‐ and late‐phase scans provided a rule‐out sensitivity of 90% and rule‐in specificity of 100% for tau pathology in CAA. Conclusions Dual‐phase 11C‐PiB PET represents a reliable approach for assessing tau and could potentially identify CAA patients for tau biomarker testing. |
| format | Article |
| id | doaj-art-45e214668aba488eafff16485ff7d506 |
| institution | OA Journals |
| issn | 2328-9503 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
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| series | Annals of Clinical and Translational Neurology |
| spelling | doaj-art-45e214668aba488eafff16485ff7d5062025-08-20T02:25:34ZengWileyAnnals of Clinical and Translational Neurology2328-95032025-05-0112590591410.1002/acn3.70021Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid AngiopathyMeng‐Ting Chiang0Chia‐Ju Liu1Bo‐Ching Lee2Ruoh‐Fang Yen3Hsin‐Hsi Tsai4Department of Nuclear Medicine Taipei Medical University Hospital Taipei TaiwanDepartment of Nuclear Medicine National Taiwan University Hospital Taipei TaiwanDepartment of Medical Imaging National Taiwan University Hospital and National Taiwan University College of Medicine Taipei TaiwanDepartment of Nuclear Medicine National Taiwan University Hospital Taipei TaiwanDepartment of Neurology National Taiwan University Hospital Taipei TaiwanABSTRACT Background Cerebral amyloid angiopathy (CAA) is a major cause of lobar intracerebral hemorrhage and cognitive dysfunction in the elderly, and frequently coexists with Alzheimer's disease and tau pathology. Dual‐phase 11C‐PiB PET detects amyloid deposition and cerebral perfusion changes and may have diagnostic value for identifying tau in CAA. Methods We prospectively enrolled patients with probable CAA for dynamic PiB and AV1451 scans. We compared early‐phase (0–6 min after tracer injection) and late‐phase (40–70 min) PiB PET between the tau(+) and tau(−) groups (based on AV1451 PET) and investigated their diagnostic values for detecting tau. Results CAA/tau(+) had lower early‐phase temporal PiB uptake than CAA/tau(−) (p = 0.014) and higher late‐phase uptake in the whole cortex and temporal and parietal lobes (all p < 0.05). Early‐phase temporal PiB SUVR correlated with tau burden (r = −0.34, p = 0.038). Using Youden's cut‐off, early‐phase and late‐phase PET had sensitivities of 55% and 80% and specificities of 85% and 65% for detecting tau, respectively. Combining early‐ and late‐phase scans provided a rule‐out sensitivity of 90% and rule‐in specificity of 100% for tau pathology in CAA. Conclusions Dual‐phase 11C‐PiB PET represents a reliable approach for assessing tau and could potentially identify CAA patients for tau biomarker testing.https://doi.org/10.1002/acn3.70021C‐11 Pittsburgh compound‐B positron emission tomography (C‐11 PiB PET)cerebral amyloid angiopathy (CAA)early‐phase amyloid PETneurodegenerationtau PET |
| spellingShingle | Meng‐Ting Chiang Chia‐Ju Liu Bo‐Ching Lee Ruoh‐Fang Yen Hsin‐Hsi Tsai Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy Annals of Clinical and Translational Neurology C‐11 Pittsburgh compound‐B positron emission tomography (C‐11 PiB PET) cerebral amyloid angiopathy (CAA) early‐phase amyloid PET neurodegeneration tau PET |
| title | Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy |
| title_full | Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy |
| title_fullStr | Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy |
| title_full_unstemmed | Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy |
| title_short | Dual‐Phase C‐11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy |
| title_sort | dual phase c 11 pib pet images for detecting tau pathology in cerebral amyloid angiopathy |
| topic | C‐11 Pittsburgh compound‐B positron emission tomography (C‐11 PiB PET) cerebral amyloid angiopathy (CAA) early‐phase amyloid PET neurodegeneration tau PET |
| url | https://doi.org/10.1002/acn3.70021 |
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