Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study
ObjectiveWe aimed to investigate the influence of Life’s Essential 8 (LE8) score trajectories on cerebral small vessel disease (CSVD).MethodsA total of 1,162 subjects from the Kailuan prospective cohort study were enrolled. The LE8 score trajectories were developed from 2006 to 2021 using trajectory...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1563288/full |
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| author | Huijing Shi Liufu Cui Ying Hui Rong Shu Haicheng Song Jierui Wang Ping Yu Shuohua Chen Jing Li Xiaoliang Liang Chunyu Ruan Jing Chen Zhenchang Wang Shouling Wu Xiaoshuai Li |
| author_facet | Huijing Shi Liufu Cui Ying Hui Rong Shu Haicheng Song Jierui Wang Ping Yu Shuohua Chen Jing Li Xiaoliang Liang Chunyu Ruan Jing Chen Zhenchang Wang Shouling Wu Xiaoshuai Li |
| author_sort | Huijing Shi |
| collection | DOAJ |
| description | ObjectiveWe aimed to investigate the influence of Life’s Essential 8 (LE8) score trajectories on cerebral small vessel disease (CSVD).MethodsA total of 1,162 subjects from the Kailuan prospective cohort study were enrolled. The LE8 score trajectories were developed from 2006 to 2021 using trajectory modeling of the SAS procedure Proc Traj. Participants were classified into three trajectory models: low stable group, medium stable group, and high stable group. Magnetic resonance imaging (MRI) was performed at the last follow-up. Ordered logistic regression and binary logistic regression models were employed to analyze the association between LE8 trajectory groups and the total CSVD score. Furthermore, we examined the relationship between LE8 trajectory groups and Various CSVD Lesions: lacunar infarcts, cerebral microbleeds (CMB), white matter hyperintensities (WMH), and enlarged perivascular spaces (EPVS).Results(1) There is a negative association between sustained high LE8 scores and the risk of CSVD. The odds ratios (OR) for an increased risk of elevated CSVD scores in the medium and high stable groups compared to the low stable group were 0.65 (95% CI: 0.47–0.88) and 0.44 (95% CI: 0.30–0.63), both of which were statistically significant. (2) LE8 had the most significant impact on lacunar infarcts, EPVS and WMH. The ORs for an increased risk of lacunar infarcts in the medium and high stable groups compared to the low stable group were 0.56 (95% CI: 0.37–0.86) and 0.25 (95% CI: 0.14–0.47), respectively. The ORs for an increased risk of BG-EPVS were 0.49 (95% CI: 0.30–0.81) and 0.31 (95% CI: 0.18–0.54), respectively. The ORs for an increased risk of WMH were 0.49 (95% CI: 0.64–1.38) and 0.58 (95% CI: 0.36–0.95), respectively. However, LE8 showed no statistically significant impact on CMB.ConclusionIn summary, our study revealed that sustained high Life’s Essential 8 scores have a protective effect against cerebral small vessel disease. |
| format | Article |
| id | doaj-art-45e0363a7d4b4f4381b606b75d07be8e |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-45e0363a7d4b4f4381b606b75d07be8e2025-08-20T03:28:26ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-07-011610.3389/fneur.2025.15632881563288Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based studyHuijing Shi0Liufu Cui1Ying Hui2Rong Shu3Haicheng Song4Jierui Wang5Ping Yu6Shuohua Chen7Jing Li8Xiaoliang Liang9Chunyu Ruan10Jing Chen11Zhenchang Wang12Shouling Wu13Xiaoshuai Li14Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, ChinaDepartment of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, ChinaDepartment of Radiology, Kailuan General Hospital, Tangshan, ChinaDepartment of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, ChinaDepartment of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, ChinaDepartment of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, ChinaDepartment of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, ChinaDepartment of Cardiology, Kailuan General Hospital, Tangshan, ChinaDepartment of Radiology, Beijing Tsinghua Changgung Hospital, Beijing, ChinaDepartment of Psychiatry, Kailuan Mental Health Centre, Tangshan, ChinaDepartment of Cardiology, Kailuan General Hospital, Tangshan, ChinaDepartment of Radiology, Kailuan General Hospital, Tangshan, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaDepartment of Cardiology, Kailuan General Hospital, Tangshan, ChinaDepartment of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, ChinaObjectiveWe aimed to investigate the influence of Life’s Essential 8 (LE8) score trajectories on cerebral small vessel disease (CSVD).MethodsA total of 1,162 subjects from the Kailuan prospective cohort study were enrolled. The LE8 score trajectories were developed from 2006 to 2021 using trajectory modeling of the SAS procedure Proc Traj. Participants were classified into three trajectory models: low stable group, medium stable group, and high stable group. Magnetic resonance imaging (MRI) was performed at the last follow-up. Ordered logistic regression and binary logistic regression models were employed to analyze the association between LE8 trajectory groups and the total CSVD score. Furthermore, we examined the relationship between LE8 trajectory groups and Various CSVD Lesions: lacunar infarcts, cerebral microbleeds (CMB), white matter hyperintensities (WMH), and enlarged perivascular spaces (EPVS).Results(1) There is a negative association between sustained high LE8 scores and the risk of CSVD. The odds ratios (OR) for an increased risk of elevated CSVD scores in the medium and high stable groups compared to the low stable group were 0.65 (95% CI: 0.47–0.88) and 0.44 (95% CI: 0.30–0.63), both of which were statistically significant. (2) LE8 had the most significant impact on lacunar infarcts, EPVS and WMH. The ORs for an increased risk of lacunar infarcts in the medium and high stable groups compared to the low stable group were 0.56 (95% CI: 0.37–0.86) and 0.25 (95% CI: 0.14–0.47), respectively. The ORs for an increased risk of BG-EPVS were 0.49 (95% CI: 0.30–0.81) and 0.31 (95% CI: 0.18–0.54), respectively. The ORs for an increased risk of WMH were 0.49 (95% CI: 0.64–1.38) and 0.58 (95% CI: 0.36–0.95), respectively. However, LE8 showed no statistically significant impact on CMB.ConclusionIn summary, our study revealed that sustained high Life’s Essential 8 scores have a protective effect against cerebral small vessel disease.https://www.frontiersin.org/articles/10.3389/fneur.2025.1563288/fullLife’s Essential 8cardiovascular healthcerebral small vessel diseasetrajectoriesrisk |
| spellingShingle | Huijing Shi Liufu Cui Ying Hui Rong Shu Haicheng Song Jierui Wang Ping Yu Shuohua Chen Jing Li Xiaoliang Liang Chunyu Ruan Jing Chen Zhenchang Wang Shouling Wu Xiaoshuai Li Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study Frontiers in Neurology Life’s Essential 8 cardiovascular health cerebral small vessel disease trajectories risk |
| title | Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study |
| title_full | Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study |
| title_fullStr | Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study |
| title_full_unstemmed | Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study |
| title_short | Sustained high Life’s Essential 8 is associated with lower risk of cerebral small vessel disease: a community-based study |
| title_sort | sustained high life s essential 8 is associated with lower risk of cerebral small vessel disease a community based study |
| topic | Life’s Essential 8 cardiovascular health cerebral small vessel disease trajectories risk |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1563288/full |
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