Deciphering the role of signal regulatory protein α in immunotherapy for solid tumors

Deciphering the role of signal regulatory protein α in immunotherapy for solid tumors

Therapies targeting immune checkpoints like programmed death receptor-1 and programmed death ligand-1 have demonstrated remarkable effectiveness in combating cancer. However, a subset of patients fails to respond to these therapies, underscoring the complexity of tumor immune evasion mechanisms. Exp...

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Bibliographic Details
Main Authors: Yulong Zhou, Xiyang Tang, Weiguang Du, Chen Shu, Xiaolong Yan, Nan Ma, Jinbo Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
CD47
immunotherapy
immune checkpoint inhibitor
SIRPα
solid tumor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1612234/full
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