Determination and validation of design space for mesenchymal stem cell cultivation processes using prediction intervals

Determination and validation of design space for mesenchymal stem cell cultivation processes using prediction intervals

Abstract In regenerative medicine, mesenchymal stem cells (MSCs) constitute a promising therapeutic route for many diseases. The current quality-by-design guidelines do not clearly define a framework for MSC production. Here, we suggest and experimentally validate a model-based method to determine d...

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Bibliographic Details
Main Authors: Keita Hirono, Yusuke Hayashi, Isuru A. Udugama, Mohamed Rami Gaddem, Kenjiro Tanaka, Yuto Takemoto, Ryuji Kato, Masahiro Kino-oka, Hirokazu Sugiyama
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08063-2
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