The effects of the post-delay epochs on working memory error reduction.
Accurate retrieval of the maintained information is crucial for working memory. This process primarily occurs during post-delay epochs, when subjects receive cues and generate responses. However, the computational and neural mechanisms that underlie these post-delay epochs to support robust memory r...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-05-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1013083 |
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| _version_ | 1849469940453605376 |
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| author | Zeyuan Ye Haoran Li Liang Tian Changsong Zhou |
| author_facet | Zeyuan Ye Haoran Li Liang Tian Changsong Zhou |
| author_sort | Zeyuan Ye |
| collection | DOAJ |
| description | Accurate retrieval of the maintained information is crucial for working memory. This process primarily occurs during post-delay epochs, when subjects receive cues and generate responses. However, the computational and neural mechanisms that underlie these post-delay epochs to support robust memory remain poorly understood. To address this, we trained recurrent neural networks (RNNs) on a color delayed-response task, where certain colors (referred to as common colors) were more frequently presented for memorization. We found that the trained RNNs reduced memory errors for common colors by decoding a broader range of neural states into these colors through the post-delay epochs. This decoding process was driven by convergent neural dynamics and a non-dynamic, biased readout process during the post-delay epochs. Our findings highlight the importance of post-delay epochs in working memory and suggest that neural systems adapt to environmental statistics by using multiple mechanisms across task epochs. |
| format | Article |
| id | doaj-art-45d4df81fb3540a58ee20bd71afb4932 |
| institution | Kabale University |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-45d4df81fb3540a58ee20bd71afb49322025-08-20T03:25:19ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582025-05-01215e101308310.1371/journal.pcbi.1013083The effects of the post-delay epochs on working memory error reduction.Zeyuan YeHaoran LiLiang TianChangsong ZhouAccurate retrieval of the maintained information is crucial for working memory. This process primarily occurs during post-delay epochs, when subjects receive cues and generate responses. However, the computational and neural mechanisms that underlie these post-delay epochs to support robust memory remain poorly understood. To address this, we trained recurrent neural networks (RNNs) on a color delayed-response task, where certain colors (referred to as common colors) were more frequently presented for memorization. We found that the trained RNNs reduced memory errors for common colors by decoding a broader range of neural states into these colors through the post-delay epochs. This decoding process was driven by convergent neural dynamics and a non-dynamic, biased readout process during the post-delay epochs. Our findings highlight the importance of post-delay epochs in working memory and suggest that neural systems adapt to environmental statistics by using multiple mechanisms across task epochs.https://doi.org/10.1371/journal.pcbi.1013083 |
| spellingShingle | Zeyuan Ye Haoran Li Liang Tian Changsong Zhou The effects of the post-delay epochs on working memory error reduction. PLoS Computational Biology |
| title | The effects of the post-delay epochs on working memory error reduction. |
| title_full | The effects of the post-delay epochs on working memory error reduction. |
| title_fullStr | The effects of the post-delay epochs on working memory error reduction. |
| title_full_unstemmed | The effects of the post-delay epochs on working memory error reduction. |
| title_short | The effects of the post-delay epochs on working memory error reduction. |
| title_sort | effects of the post delay epochs on working memory error reduction |
| url | https://doi.org/10.1371/journal.pcbi.1013083 |
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