Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that are widely involved in various physiological functions. They are widely expressed through the reproductive system. Their roles in the metabolism and function of sex steroids and thus the etiology of repro...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3203161 |
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| author | Qiansheng Huang Qionghua Chen |
| author_facet | Qiansheng Huang Qionghua Chen |
| author_sort | Qiansheng Huang |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that are widely involved in various physiological functions. They are widely expressed through the reproductive system. Their roles in the metabolism and function of sex steroids and thus the etiology of reproductive disorders receive great concern. Various kinds of exogenous chemicals, especially environmental pollutants, exert their adverse impact on the reproductive system through disturbing the PPAR signaling pathway. Chemicals could bind to PPARs and modulate the transcription of downstream genes containing PPRE (peroxisome proliferator response element). This will lead to altered expression of genes related to metabolism of sex steroids and thus the abnormal physiological function of sex steroids. In this review, various kinds of environmental ligands are summarized and discussed. Their interactions with three types of PPARs are classified by various data from transcript profiles, PPRE reporter in cell line, in silico docking, and gene silencing. The review will contribute to the understanding of the roles of PPARs in the reproductive toxicology of environmental chemicals. |
| format | Article |
| id | doaj-art-45d443853eee4baa9ca229d953abc461 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-45d443853eee4baa9ca229d953abc4612025-02-03T06:08:11ZengWileyPPAR Research1687-47571687-47652017-01-01201710.1155/2017/32031613203161Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex SteroidsQiansheng Huang0Qionghua Chen1Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, ChinaThe First Affiliated Hospital of Xiamen University, Xiamen 361003, ChinaPeroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that are widely involved in various physiological functions. They are widely expressed through the reproductive system. Their roles in the metabolism and function of sex steroids and thus the etiology of reproductive disorders receive great concern. Various kinds of exogenous chemicals, especially environmental pollutants, exert their adverse impact on the reproductive system through disturbing the PPAR signaling pathway. Chemicals could bind to PPARs and modulate the transcription of downstream genes containing PPRE (peroxisome proliferator response element). This will lead to altered expression of genes related to metabolism of sex steroids and thus the abnormal physiological function of sex steroids. In this review, various kinds of environmental ligands are summarized and discussed. Their interactions with three types of PPARs are classified by various data from transcript profiles, PPRE reporter in cell line, in silico docking, and gene silencing. The review will contribute to the understanding of the roles of PPARs in the reproductive toxicology of environmental chemicals.http://dx.doi.org/10.1155/2017/3203161 |
| spellingShingle | Qiansheng Huang Qionghua Chen Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids PPAR Research |
| title | Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids |
| title_full | Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids |
| title_fullStr | Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids |
| title_full_unstemmed | Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids |
| title_short | Mediating Roles of PPARs in the Effects of Environmental Chemicals on Sex Steroids |
| title_sort | mediating roles of ppars in the effects of environmental chemicals on sex steroids |
| url | http://dx.doi.org/10.1155/2017/3203161 |
| work_keys_str_mv | AT qianshenghuang mediatingrolesofpparsintheeffectsofenvironmentalchemicalsonsexsteroids AT qionghuachen mediatingrolesofpparsintheeffectsofenvironmentalchemicalsonsexsteroids |