Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications
Aim. Sickle cell disease has witnessed a 41.4% surge from 2000 to 2021, significantly affecting morbidity and mortality rates, particularly in children from regions with elevated under-5 mortality rates. Gut microbiota dysbiosis is increasingly recognised in SCD, exacerbating complications, particul...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Anemia |
| Online Access: | http://dx.doi.org/10.1155/2024/5431000 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850104632937807872 |
|---|---|
| author | Tarimoboere Agbalalah Doofan Bur Ezinne JaneFrances Nwonu Adekunle Babajide Rowaiye |
| author_facet | Tarimoboere Agbalalah Doofan Bur Ezinne JaneFrances Nwonu Adekunle Babajide Rowaiye |
| author_sort | Tarimoboere Agbalalah |
| collection | DOAJ |
| description | Aim. Sickle cell disease has witnessed a 41.4% surge from 2000 to 2021, significantly affecting morbidity and mortality rates, particularly in children from regions with elevated under-5 mortality rates. Gut microbiota dysbiosis is increasingly recognised in SCD, exacerbating complications, particularly chronic pain, marked by significant alterations of proinflammatory bacteria abundance. This review explores the therapeutic potential of Akkermansia muciniphila and Roseburia spp. in alleviating SCD-related complications, emphasising their roles in maintaining gut barrier integrity, reducing inflammation, and modulating immune responses. Method. A literature search up to November 2023 using PubMed, MEDLINE, and Google Scholar databases explored SCD pathophysiology, gut microbiota composition, Akkermansia muciniphila and Roseburia spp. abundance, pain and gut dysbiosis in SCD, and butyrate therapy. Result. A. muciniphila and Roseburia spp. supplementation shows promise in alleviating chronic pain by addressing gut dysbiosis, offering new avenues for sustainable SCD management. This approach holds the potential for reducing reliance on reactive treatments and improving overall quality of life. This research underscores the pivotal role of the gut microbiome in SCD, advocating for personalised treatment approaches. Conclusion. Further exploration and clinical trials are needed to harness the full potential of these gut bacteria for individuals affected by this challenging condition. |
| format | Article |
| id | doaj-art-45c46e33a53947899c68be4c2dc7efa7 |
| institution | DOAJ |
| issn | 2090-1275 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Anemia |
| spelling | doaj-art-45c46e33a53947899c68be4c2dc7efa72025-08-20T02:39:18ZengWileyAnemia2090-12752024-01-01202410.1155/2024/5431000Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and ComplicationsTarimoboere Agbalalah0Doofan Bur1Ezinne JaneFrances Nwonu2Adekunle Babajide Rowaiye3Department of AnatomyDepartment of Medical BiotechnologyDepartment of Medical BiotechnologyDepartment of Agricultural BiotechnologyAim. Sickle cell disease has witnessed a 41.4% surge from 2000 to 2021, significantly affecting morbidity and mortality rates, particularly in children from regions with elevated under-5 mortality rates. Gut microbiota dysbiosis is increasingly recognised in SCD, exacerbating complications, particularly chronic pain, marked by significant alterations of proinflammatory bacteria abundance. This review explores the therapeutic potential of Akkermansia muciniphila and Roseburia spp. in alleviating SCD-related complications, emphasising their roles in maintaining gut barrier integrity, reducing inflammation, and modulating immune responses. Method. A literature search up to November 2023 using PubMed, MEDLINE, and Google Scholar databases explored SCD pathophysiology, gut microbiota composition, Akkermansia muciniphila and Roseburia spp. abundance, pain and gut dysbiosis in SCD, and butyrate therapy. Result. A. muciniphila and Roseburia spp. supplementation shows promise in alleviating chronic pain by addressing gut dysbiosis, offering new avenues for sustainable SCD management. This approach holds the potential for reducing reliance on reactive treatments and improving overall quality of life. This research underscores the pivotal role of the gut microbiome in SCD, advocating for personalised treatment approaches. Conclusion. Further exploration and clinical trials are needed to harness the full potential of these gut bacteria for individuals affected by this challenging condition.http://dx.doi.org/10.1155/2024/5431000 |
| spellingShingle | Tarimoboere Agbalalah Doofan Bur Ezinne JaneFrances Nwonu Adekunle Babajide Rowaiye Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications Anemia |
| title | Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications |
| title_full | Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications |
| title_fullStr | Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications |
| title_full_unstemmed | Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications |
| title_short | Gut Microbiota: Potential Therapeutic Target for Sickle Cell Disease Pain and Complications |
| title_sort | gut microbiota potential therapeutic target for sickle cell disease pain and complications |
| url | http://dx.doi.org/10.1155/2024/5431000 |
| work_keys_str_mv | AT tarimoboereagbalalah gutmicrobiotapotentialtherapeutictargetforsicklecelldiseasepainandcomplications AT doofanbur gutmicrobiotapotentialtherapeutictargetforsicklecelldiseasepainandcomplications AT ezinnejanefrancesnwonu gutmicrobiotapotentialtherapeutictargetforsicklecelldiseasepainandcomplications AT adekunlebabajiderowaiye gutmicrobiotapotentialtherapeutictargetforsicklecelldiseasepainandcomplications |