The significance of adiponectin as a biomarker in metabolic syndrome and/or coronary artery disease
Introduction/Aim. Adiponectin exerts profound protective actions during insulin resistence or prediabetes progression towards more severe clinical entities such as metabolic syndrome and/or cardiovascular disease. Since hypoadiponectinaemia contributes to the pathophysiology of the metaboli...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2015-01-01
|
| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2015/0042-84501500067S.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Introduction/Aim. Adiponectin exerts profound protective actions during
insulin resistence or prediabetes progression towards more severe clinical
entities such as metabolic syndrome and/or cardiovascular disease. Since
hypoadiponectinaemia contributes to the pathophysiology of the metabolic
syndrome and coronary artery disease the level of circulating adiponectin may
be an early marker of cardiovascular events. The aim of this study was to
determine the relationships between serum adiponectin levels and parameters
of both insulin sensitivity and obesity in patients with the metabolic
syndrome and/or coronary artery disease, as well as to assess predictive
value of adiponectin serum levels as a biomarker of these entitetis. Methods.
The study included 100 patients with metabolic syndrome and/or coronary
artery disease with different degree of insulin resistance and healthy,
normoglycemic individuals. The control group comprising healthy,
normoglycemic individuals was used for comparison. Serum level of
adiponectin, fasting glucose, fasting insulinemia Homeostasis Model
Assessment of Insulin Resistance (HOMAIR) index and anthropometric parameters
were determined in all the subjects. Adiponectin was measured by using the
ultrasensitive ELISA method. Insulinemia was measured by the radioimmunoassay
(RIA) method. The presence of glycemic disorders was assessed on the basis of
oral glucose tolerance test (OGTT). Results. Adiponectin level was inversely
correlated with age (ρ = - 0.015), parameters of both obesity (R = 0.437; p <
0.001) and insulin resistance (R = 0.374; p < 0.01). Decreasing in the level
of adiponectin was strongly implicated in the development of insulin
resistance. Most importantly, a statistically significant rapid decrease in
adiponectin was in the prediabetic stages (p < 0.01). The predictor value of
adiponectin was 1,356.32 ± 402.65 рg/mL. Conclusions. The obtained resultats
suggest that adiponectin may be a useful marker in identification of
individuals with risk of developing metabolic syndrome and coronary artery
disease, as well as a predictor of prediabetes. |
|---|---|
| ISSN: | 0042-8450 2406-0720 |