Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells
The proliferation of tumors is not merely self-regulated by the cancer cells but is also intrinsically connected to the tumor microenvironment (TME). Within this complex TME, cancer-associated fibroblasts (CAFs) are pivotal in the modulation of tumor onset and progression. Rich signaling interaction...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1469918/full |
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| author | Chenbo Yang Chenbo Yang Jiao Shu Jiao Shu Yiwei Li Yiwei Li Yiwei Li Na Zhao Na Zhao Xiaonan Liu Xiaonan Liu Xiangyu Tian Xiangyu Tian Zexin Sun Zexin Sun Zexin Sun Muhammad Saud Tabish Muhammad Saud Tabish Yichen Hong Yichen Hong Yichen Hong Kuisheng Chen Kuisheng Chen Miaomiao Sun Miaomiao Sun |
| author_facet | Chenbo Yang Chenbo Yang Jiao Shu Jiao Shu Yiwei Li Yiwei Li Yiwei Li Na Zhao Na Zhao Xiaonan Liu Xiaonan Liu Xiangyu Tian Xiangyu Tian Zexin Sun Zexin Sun Zexin Sun Muhammad Saud Tabish Muhammad Saud Tabish Yichen Hong Yichen Hong Yichen Hong Kuisheng Chen Kuisheng Chen Miaomiao Sun Miaomiao Sun |
| author_sort | Chenbo Yang |
| collection | DOAJ |
| description | The proliferation of tumors is not merely self-regulated by the cancer cells but is also intrinsically connected to the tumor microenvironment (TME). Within this complex TME, cancer-associated fibroblasts (CAFs) are pivotal in the modulation of tumor onset and progression. Rich signaling interactions exist between CAFs and tumor cells, which are crucial for tumor regulation. Long non-coding RNAs (LncRNAs) emerge from cellular transcription as a class of functionally diverse RNA molecules. Recent studies have revealed that LncRNAs are integral to the crosstalk between CAFs and tumor cells, with the capacity to modify cellular transcriptional activity and secretion profiles, thus facilitating CAFs activation, tumor proliferation, metastasis, drug resistance, and other related functionalities. This comprehensive review revisits the latest research on LncRNA-mediated interactions between CAFs and tumor cells, encapsulates the biological roles of LncRNAs, and delves into the molecular pathways from a broader perspective, aspiring to offer novel perspectives for a deeper comprehension of the etiology of tumors and the enhancement of therapeutic approaches. |
| format | Article |
| id | doaj-art-45bdca9de1f6496f96c076261aa6ae2b |
| institution | OA Journals |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-45bdca9de1f6496f96c076261aa6ae2b2025-08-20T02:30:38ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-12-011510.3389/fimmu.2024.14699181469918Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cellsChenbo Yang0Chenbo Yang1Jiao Shu2Jiao Shu3Yiwei Li4Yiwei Li5Yiwei Li6Na Zhao7Na Zhao8Xiaonan Liu9Xiaonan Liu10Xiangyu Tian11Xiangyu Tian12Zexin Sun13Zexin Sun14Zexin Sun15Muhammad Saud Tabish16Muhammad Saud Tabish17Yichen Hong18Yichen Hong19Yichen Hong20Kuisheng Chen21Kuisheng Chen22Miaomiao Sun23Miaomiao Sun24Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaHenan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaHenan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaHenan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaDepartment of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan Key Laboratory of Tumor Pathology, Zhengzhou University, Zhengzhou, ChinaThe proliferation of tumors is not merely self-regulated by the cancer cells but is also intrinsically connected to the tumor microenvironment (TME). Within this complex TME, cancer-associated fibroblasts (CAFs) are pivotal in the modulation of tumor onset and progression. Rich signaling interactions exist between CAFs and tumor cells, which are crucial for tumor regulation. Long non-coding RNAs (LncRNAs) emerge from cellular transcription as a class of functionally diverse RNA molecules. Recent studies have revealed that LncRNAs are integral to the crosstalk between CAFs and tumor cells, with the capacity to modify cellular transcriptional activity and secretion profiles, thus facilitating CAFs activation, tumor proliferation, metastasis, drug resistance, and other related functionalities. This comprehensive review revisits the latest research on LncRNA-mediated interactions between CAFs and tumor cells, encapsulates the biological roles of LncRNAs, and delves into the molecular pathways from a broader perspective, aspiring to offer novel perspectives for a deeper comprehension of the etiology of tumors and the enhancement of therapeutic approaches.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1469918/fulllong non-coding RNAscancer-associated fibroblaststumor microenvironmentsignaling pathwaytumor growth |
| spellingShingle | Chenbo Yang Chenbo Yang Jiao Shu Jiao Shu Yiwei Li Yiwei Li Yiwei Li Na Zhao Na Zhao Xiaonan Liu Xiaonan Liu Xiangyu Tian Xiangyu Tian Zexin Sun Zexin Sun Zexin Sun Muhammad Saud Tabish Muhammad Saud Tabish Yichen Hong Yichen Hong Yichen Hong Kuisheng Chen Kuisheng Chen Miaomiao Sun Miaomiao Sun Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells Frontiers in Immunology long non-coding RNAs cancer-associated fibroblasts tumor microenvironment signaling pathway tumor growth |
| title | Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_full | Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_fullStr | Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_full_unstemmed | Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_short | Long non-coding RNAs are involved in the crosstalk between cancer-associated fibroblasts and tumor cells |
| title_sort | long non coding rnas are involved in the crosstalk between cancer associated fibroblasts and tumor cells |
| topic | long non-coding RNAs cancer-associated fibroblasts tumor microenvironment signaling pathway tumor growth |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1469918/full |
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