Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study
<b>Objectives:</b> This study aimed to analyse the haematological parameters in relation to subjective tinnitus. We hypothesise that abnormal haematological findings may correlate with increased severity and chronicity of tinnitus. This research could lead to improved diagnostic methods...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-06-01
|
| Series: | Audiology Research |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2039-4349/15/3/72 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849418189452083200 |
|---|---|
| author | Stefani Maihoub Panayiota Mavrogeni Gábor Dénes Répássy András Molnár |
| author_facet | Stefani Maihoub Panayiota Mavrogeni Gábor Dénes Répássy András Molnár |
| author_sort | Stefani Maihoub |
| collection | DOAJ |
| description | <b>Objectives:</b> This study aimed to analyse the haematological parameters in relation to subjective tinnitus. We hypothesise that abnormal haematological findings may correlate with increased severity and chronicity of tinnitus. This research could lead to improved diagnostic methods and more targeted treatments. <b>Material and Methods:</b> A total of 439 patients with primary subjective tinnitus and 274 individuals without tinnitus were enrolled. These participants underwent comprehensive laboratory testing, which included haematological parameters. <b>Results:</b> When comparing the white blood cell levels between the tinnitus group and the control group, no statistically significant differences were found (<i>p</i> = 0.743). Similarly, comparisons of red blood cell levels (<i>p</i> = 0.250), haemoglobin levels (<i>p</i> = 0.087), and haematocrit levels (<i>p</i> = 0.066) also revealed no significant differences. The platelet levels showed no significant difference between the two groups (<i>p</i> = 0.782). According to a logistic regression model, lower levels of haemoglobin (<i>p</i> = 0.000) and platelets (<i>p</i> = 0.000) significantly predicted higher scores on the Tinnitus Handicap Inventory, indicating self-reported tinnitus severity. Furthermore, lower haemoglobin levels were significant predictors (<i>p</i> = 0.04) of developing bilateral tinnitus. Using Spearman’s correlation test, a statistically significant negative correlation (<i>p</i> = 0.029) was observed between red blood cell levels and the onset of tinnitus. The frequency of tinnitus demonstrated a significant positive correlation with haemoglobin levels (<i>p</i> = 0.04) and haematocrit levels (<i>p</i> = 0.043). Conversely, platelet levels showed a significant negative correlation with both tinnitus intensity (<i>p</i> = 0.002) and the onset of tinnitus (<i>p</i> = 0.033). <b>Conclusions:</b> While the haematological parameters showed no significant differences between the tinnitus and control groups, further analyses indicated that certain parameters, such as haemoglobin and haematocrit levels, could potentially influence tinnitus, necessitating further investigation. |
| format | Article |
| id | doaj-art-45bbf253deb2404fa29fd721dc795986 |
| institution | Kabale University |
| issn | 2039-4349 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Audiology Research |
| spelling | doaj-art-45bbf253deb2404fa29fd721dc7959862025-08-20T03:32:31ZengMDPI AGAudiology Research2039-43492025-06-011537210.3390/audiolres15030072Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control StudyStefani Maihoub0Panayiota Mavrogeni1Gábor Dénes Répássy2András Molnár3Maihoub ENT Clinic, Aliakmona Street 16, Limassol 3117, CyprusTóth Ilona Health Service, Clinical Medical Institute, Görgey Artúr Tér 8, 1212 Budapest, HungaryDepartment of Otorhinolaryngology and Head and Neck Surgery, Semmelweis University, Szigony u. 36, 1083 Budapest, HungaryOpera Clinic, Protone Audio Kft., Lázár u. 4, 1065 Budapest, Hungary<b>Objectives:</b> This study aimed to analyse the haematological parameters in relation to subjective tinnitus. We hypothesise that abnormal haematological findings may correlate with increased severity and chronicity of tinnitus. This research could lead to improved diagnostic methods and more targeted treatments. <b>Material and Methods:</b> A total of 439 patients with primary subjective tinnitus and 274 individuals without tinnitus were enrolled. These participants underwent comprehensive laboratory testing, which included haematological parameters. <b>Results:</b> When comparing the white blood cell levels between the tinnitus group and the control group, no statistically significant differences were found (<i>p</i> = 0.743). Similarly, comparisons of red blood cell levels (<i>p</i> = 0.250), haemoglobin levels (<i>p</i> = 0.087), and haematocrit levels (<i>p</i> = 0.066) also revealed no significant differences. The platelet levels showed no significant difference between the two groups (<i>p</i> = 0.782). According to a logistic regression model, lower levels of haemoglobin (<i>p</i> = 0.000) and platelets (<i>p</i> = 0.000) significantly predicted higher scores on the Tinnitus Handicap Inventory, indicating self-reported tinnitus severity. Furthermore, lower haemoglobin levels were significant predictors (<i>p</i> = 0.04) of developing bilateral tinnitus. Using Spearman’s correlation test, a statistically significant negative correlation (<i>p</i> = 0.029) was observed between red blood cell levels and the onset of tinnitus. The frequency of tinnitus demonstrated a significant positive correlation with haemoglobin levels (<i>p</i> = 0.04) and haematocrit levels (<i>p</i> = 0.043). Conversely, platelet levels showed a significant negative correlation with both tinnitus intensity (<i>p</i> = 0.002) and the onset of tinnitus (<i>p</i> = 0.033). <b>Conclusions:</b> While the haematological parameters showed no significant differences between the tinnitus and control groups, further analyses indicated that certain parameters, such as haemoglobin and haematocrit levels, could potentially influence tinnitus, necessitating further investigation.https://www.mdpi.com/2039-4349/15/3/72subjective tinnitusblood cell levelshaematological parameterstinnitus severity |
| spellingShingle | Stefani Maihoub Panayiota Mavrogeni Gábor Dénes Répássy András Molnár Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study Audiology Research subjective tinnitus blood cell levels haematological parameters tinnitus severity |
| title | Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study |
| title_full | Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study |
| title_fullStr | Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study |
| title_full_unstemmed | Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study |
| title_short | Exploring How Blood Cell Levels Influence Subjective Tinnitus: A Cross-Sectional Case-Control Study |
| title_sort | exploring how blood cell levels influence subjective tinnitus a cross sectional case control study |
| topic | subjective tinnitus blood cell levels haematological parameters tinnitus severity |
| url | https://www.mdpi.com/2039-4349/15/3/72 |
| work_keys_str_mv | AT stefanimaihoub exploringhowbloodcelllevelsinfluencesubjectivetinnitusacrosssectionalcasecontrolstudy AT panayiotamavrogeni exploringhowbloodcelllevelsinfluencesubjectivetinnitusacrosssectionalcasecontrolstudy AT gabordenesrepassy exploringhowbloodcelllevelsinfluencesubjectivetinnitusacrosssectionalcasecontrolstudy AT andrasmolnar exploringhowbloodcelllevelsinfluencesubjectivetinnitusacrosssectionalcasecontrolstudy |