Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study

Background. Caffeine is widely used to treat apnea of prematurity. Here, we evaluated the efficacy of early caffeine (1-2 DOL) in decreasing the incidence of adverse neonatal outcomes. Methods. A retrospective cohort was used to compare the neonatal morbidity of 150 preterm neonates with gestational...

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Main Authors: Ivan Hand, Nahla Zaghloul, Lily Barash, Rudolph Parris, Ulrika Aden, Hsiu-Ling Li
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:International Journal of Pediatrics
Online Access:http://dx.doi.org/10.1155/2016/9478204
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author Ivan Hand
Nahla Zaghloul
Lily Barash
Rudolph Parris
Ulrika Aden
Hsiu-Ling Li
author_facet Ivan Hand
Nahla Zaghloul
Lily Barash
Rudolph Parris
Ulrika Aden
Hsiu-Ling Li
author_sort Ivan Hand
collection DOAJ
description Background. Caffeine is widely used to treat apnea of prematurity. Here, we evaluated the efficacy of early caffeine (1-2 DOL) in decreasing the incidence of adverse neonatal outcomes. Methods. A retrospective cohort was used to compare the neonatal morbidity of 150 preterm neonates with gestational age ≤29 weeks. Infants were divided into 3 groups based on the initiation timing of caffeine therapy; (1) early caffeine (1-2 DOL), (2) late caffeine (3–7 DOL), and (3) very late caffeine (≥8 DOL). Results. The neonatal outcomes of early caffeine were comparable with those of the late caffeine group. Moreover, when comparing the neonatal morbidity of the very late caffeine group with that of the early caffeine group, multivariable logistic regression analyses were performed. We found that the timing of caffeine did not influence the risk of BPD (OR, 0.393; CI, 0.126–1.223; p=0.107), but birthweight did (OR, 0.996; CI, 0.993–0.999; p=0.018) in these infants. Conclusion. Neonatal outcomes of preterm infants were comparable whether caffeine was administered early or late in the first 7 DOL. The risk of BPD in infants receiving caffeine after 8 DOL was irrespective of delayed treatment with caffeine. Our results clearly demonstrate the need for further studies before caffeine prophylaxis can be universally recommended.
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spelling doaj-art-45b86dba3aa844b086483574afc27b4f2025-02-03T05:54:40ZengWileyInternational Journal of Pediatrics1687-97401687-97592016-01-01201610.1155/2016/94782049478204Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective StudyIvan Hand0Nahla Zaghloul1Lily Barash2Rudolph Parris3Ulrika Aden4Hsiu-Ling Li5Department of Pediatrics/Division of Neonatology, Kings County Hospital, Brooklyn, NY, USACohen Children’s Hospital at New York-North Shore Health System, Manhasset, NY, USADepartment of Pediatrics/Division of Neonatology, Kings County Hospital, Brooklyn, NY, USADepartment of Pediatrics, SUNY-Downstate Medical Center, Brooklyn, NY, USADepartment of Women’s and Children’s Health, Karolinska Institute, SwedenDepartment of Physiology and Pharmacology, SUNY-Downstate Medical Center, Brooklyn, NY, USABackground. Caffeine is widely used to treat apnea of prematurity. Here, we evaluated the efficacy of early caffeine (1-2 DOL) in decreasing the incidence of adverse neonatal outcomes. Methods. A retrospective cohort was used to compare the neonatal morbidity of 150 preterm neonates with gestational age ≤29 weeks. Infants were divided into 3 groups based on the initiation timing of caffeine therapy; (1) early caffeine (1-2 DOL), (2) late caffeine (3–7 DOL), and (3) very late caffeine (≥8 DOL). Results. The neonatal outcomes of early caffeine were comparable with those of the late caffeine group. Moreover, when comparing the neonatal morbidity of the very late caffeine group with that of the early caffeine group, multivariable logistic regression analyses were performed. We found that the timing of caffeine did not influence the risk of BPD (OR, 0.393; CI, 0.126–1.223; p=0.107), but birthweight did (OR, 0.996; CI, 0.993–0.999; p=0.018) in these infants. Conclusion. Neonatal outcomes of preterm infants were comparable whether caffeine was administered early or late in the first 7 DOL. The risk of BPD in infants receiving caffeine after 8 DOL was irrespective of delayed treatment with caffeine. Our results clearly demonstrate the need for further studies before caffeine prophylaxis can be universally recommended.http://dx.doi.org/10.1155/2016/9478204
spellingShingle Ivan Hand
Nahla Zaghloul
Lily Barash
Rudolph Parris
Ulrika Aden
Hsiu-Ling Li
Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study
International Journal of Pediatrics
title Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study
title_full Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study
title_fullStr Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study
title_full_unstemmed Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study
title_short Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study
title_sort timing of caffeine therapy and neonatal outcomes in preterm infants a retrospective study
url http://dx.doi.org/10.1155/2016/9478204
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