Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study
Background. Caffeine is widely used to treat apnea of prematurity. Here, we evaluated the efficacy of early caffeine (1-2 DOL) in decreasing the incidence of adverse neonatal outcomes. Methods. A retrospective cohort was used to compare the neonatal morbidity of 150 preterm neonates with gestational...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2016/9478204 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553187692773376 |
|---|---|
| author | Ivan Hand Nahla Zaghloul Lily Barash Rudolph Parris Ulrika Aden Hsiu-Ling Li |
| author_facet | Ivan Hand Nahla Zaghloul Lily Barash Rudolph Parris Ulrika Aden Hsiu-Ling Li |
| author_sort | Ivan Hand |
| collection | DOAJ |
| description | Background. Caffeine is widely used to treat apnea of prematurity. Here, we evaluated the efficacy of early caffeine (1-2 DOL) in decreasing the incidence of adverse neonatal outcomes. Methods. A retrospective cohort was used to compare the neonatal morbidity of 150 preterm neonates with gestational age ≤29 weeks. Infants were divided into 3 groups based on the initiation timing of caffeine therapy; (1) early caffeine (1-2 DOL), (2) late caffeine (3–7 DOL), and (3) very late caffeine (≥8 DOL). Results. The neonatal outcomes of early caffeine were comparable with those of the late caffeine group. Moreover, when comparing the neonatal morbidity of the very late caffeine group with that of the early caffeine group, multivariable logistic regression analyses were performed. We found that the timing of caffeine did not influence the risk of BPD (OR, 0.393; CI, 0.126–1.223; p=0.107), but birthweight did (OR, 0.996; CI, 0.993–0.999; p=0.018) in these infants. Conclusion. Neonatal outcomes of preterm infants were comparable whether caffeine was administered early or late in the first 7 DOL. The risk of BPD in infants receiving caffeine after 8 DOL was irrespective of delayed treatment with caffeine. Our results clearly demonstrate the need for further studies before caffeine prophylaxis can be universally recommended. |
| format | Article |
| id | doaj-art-45b86dba3aa844b086483574afc27b4f |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-45b86dba3aa844b086483574afc27b4f2025-02-03T05:54:40ZengWileyInternational Journal of Pediatrics1687-97401687-97592016-01-01201610.1155/2016/94782049478204Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective StudyIvan Hand0Nahla Zaghloul1Lily Barash2Rudolph Parris3Ulrika Aden4Hsiu-Ling Li5Department of Pediatrics/Division of Neonatology, Kings County Hospital, Brooklyn, NY, USACohen Children’s Hospital at New York-North Shore Health System, Manhasset, NY, USADepartment of Pediatrics/Division of Neonatology, Kings County Hospital, Brooklyn, NY, USADepartment of Pediatrics, SUNY-Downstate Medical Center, Brooklyn, NY, USADepartment of Women’s and Children’s Health, Karolinska Institute, SwedenDepartment of Physiology and Pharmacology, SUNY-Downstate Medical Center, Brooklyn, NY, USABackground. Caffeine is widely used to treat apnea of prematurity. Here, we evaluated the efficacy of early caffeine (1-2 DOL) in decreasing the incidence of adverse neonatal outcomes. Methods. A retrospective cohort was used to compare the neonatal morbidity of 150 preterm neonates with gestational age ≤29 weeks. Infants were divided into 3 groups based on the initiation timing of caffeine therapy; (1) early caffeine (1-2 DOL), (2) late caffeine (3–7 DOL), and (3) very late caffeine (≥8 DOL). Results. The neonatal outcomes of early caffeine were comparable with those of the late caffeine group. Moreover, when comparing the neonatal morbidity of the very late caffeine group with that of the early caffeine group, multivariable logistic regression analyses were performed. We found that the timing of caffeine did not influence the risk of BPD (OR, 0.393; CI, 0.126–1.223; p=0.107), but birthweight did (OR, 0.996; CI, 0.993–0.999; p=0.018) in these infants. Conclusion. Neonatal outcomes of preterm infants were comparable whether caffeine was administered early or late in the first 7 DOL. The risk of BPD in infants receiving caffeine after 8 DOL was irrespective of delayed treatment with caffeine. Our results clearly demonstrate the need for further studies before caffeine prophylaxis can be universally recommended.http://dx.doi.org/10.1155/2016/9478204 |
| spellingShingle | Ivan Hand Nahla Zaghloul Lily Barash Rudolph Parris Ulrika Aden Hsiu-Ling Li Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study International Journal of Pediatrics |
| title | Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study |
| title_full | Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study |
| title_fullStr | Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study |
| title_full_unstemmed | Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study |
| title_short | Timing of Caffeine Therapy and Neonatal Outcomes in Preterm Infants: A Retrospective Study |
| title_sort | timing of caffeine therapy and neonatal outcomes in preterm infants a retrospective study |
| url | http://dx.doi.org/10.1155/2016/9478204 |
| work_keys_str_mv | AT ivanhand timingofcaffeinetherapyandneonataloutcomesinpreterminfantsaretrospectivestudy AT nahlazaghloul timingofcaffeinetherapyandneonataloutcomesinpreterminfantsaretrospectivestudy AT lilybarash timingofcaffeinetherapyandneonataloutcomesinpreterminfantsaretrospectivestudy AT rudolphparris timingofcaffeinetherapyandneonataloutcomesinpreterminfantsaretrospectivestudy AT ulrikaaden timingofcaffeinetherapyandneonataloutcomesinpreterminfantsaretrospectivestudy AT hsiulingli timingofcaffeinetherapyandneonataloutcomesinpreterminfantsaretrospectivestudy |