Receptor tyrosine kinases and steroid hormone receptors in breast cancer: Review of recent evidences
Breast cancer development and progression are driven by intricate networks involving receptor tyrosine kinases (RTKs) and steroid hormone receptors specifically estrogen receptor (ER) and progesterone receptor (PR). This review examined roles of each receptor under normal physiology and in breast ca...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Metabolism Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589936824000562 |
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| author | Awgichew Behaile Teklemariam Zelalem Tilahun Muche Melaku Mekonnen Agidew Anemut Tilahun Mulu Edgeit Abebe Zewde Nega Dagnew Baye Dagnew Getnet Adugna Lemlemu Maru Teklie Mengie Ayele |
| author_facet | Awgichew Behaile Teklemariam Zelalem Tilahun Muche Melaku Mekonnen Agidew Anemut Tilahun Mulu Edgeit Abebe Zewde Nega Dagnew Baye Dagnew Getnet Adugna Lemlemu Maru Teklie Mengie Ayele |
| author_sort | Awgichew Behaile Teklemariam |
| collection | DOAJ |
| description | Breast cancer development and progression are driven by intricate networks involving receptor tyrosine kinases (RTKs) and steroid hormone receptors specifically estrogen receptor (ER) and progesterone receptor (PR). This review examined roles of each receptor under normal physiology and in breast cancer, and explored their multifaceted interactions via signaling pathways, focusing on their contributions to breast cancer progression. Since defining the mechanism by which these two-receptor mediated signaling pathways cooperate is essential for understanding breast cancer progression, we discussed the mechanisms of cross-talk between RTKs and ER and PR and their potential therapeutic implications as well. The crosstalk between RTKs and steroid hormone receptors (ER and PR) in breast cancer can influence the disease's progression and treatment outcomes. Therefore, understanding the functions of the aforementioned receptors and their interactions is crucial for developing effective therapies. |
| format | Article |
| id | doaj-art-45b7dcb96dff4abc921213c58447fda8 |
| institution | DOAJ |
| issn | 2589-9368 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Metabolism Open |
| spelling | doaj-art-45b7dcb96dff4abc921213c58447fda82025-08-20T02:50:20ZengElsevierMetabolism Open2589-93682024-12-012410032410.1016/j.metop.2024.100324Receptor tyrosine kinases and steroid hormone receptors in breast cancer: Review of recent evidencesAwgichew Behaile Teklemariam0Zelalem Tilahun Muche1Melaku Mekonnen Agidew2Anemut Tilahun Mulu3Edgeit Abebe Zewde4Nega Dagnew Baye5Dagnew Getnet Adugna6Lemlemu Maru7Teklie Mengie Ayele8Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; Corresponding author. P. O. Box: 272; 6300, Debre Tabor, EthiopiaDepartment of Medical Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Medical Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Human Anatomy, School of Medicine, College of Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Human Anatomy, School of Medicine, College of Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Medical Physiology, School of Medicine, College of Health Sciences, University of Gondar, Gondar, EthiopiaDepartment of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaBreast cancer development and progression are driven by intricate networks involving receptor tyrosine kinases (RTKs) and steroid hormone receptors specifically estrogen receptor (ER) and progesterone receptor (PR). This review examined roles of each receptor under normal physiology and in breast cancer, and explored their multifaceted interactions via signaling pathways, focusing on their contributions to breast cancer progression. Since defining the mechanism by which these two-receptor mediated signaling pathways cooperate is essential for understanding breast cancer progression, we discussed the mechanisms of cross-talk between RTKs and ER and PR and their potential therapeutic implications as well. The crosstalk between RTKs and steroid hormone receptors (ER and PR) in breast cancer can influence the disease's progression and treatment outcomes. Therefore, understanding the functions of the aforementioned receptors and their interactions is crucial for developing effective therapies.http://www.sciencedirect.com/science/article/pii/S2589936824000562Breast cancerCross-talkERPRRTKs |
| spellingShingle | Awgichew Behaile Teklemariam Zelalem Tilahun Muche Melaku Mekonnen Agidew Anemut Tilahun Mulu Edgeit Abebe Zewde Nega Dagnew Baye Dagnew Getnet Adugna Lemlemu Maru Teklie Mengie Ayele Receptor tyrosine kinases and steroid hormone receptors in breast cancer: Review of recent evidences Metabolism Open Breast cancer Cross-talk ER PR RTKs |
| title | Receptor tyrosine kinases and steroid hormone receptors in breast cancer: Review of recent evidences |
| title_full | Receptor tyrosine kinases and steroid hormone receptors in breast cancer: Review of recent evidences |
| title_fullStr | Receptor tyrosine kinases and steroid hormone receptors in breast cancer: Review of recent evidences |
| title_full_unstemmed | Receptor tyrosine kinases and steroid hormone receptors in breast cancer: Review of recent evidences |
| title_short | Receptor tyrosine kinases and steroid hormone receptors in breast cancer: Review of recent evidences |
| title_sort | receptor tyrosine kinases and steroid hormone receptors in breast cancer review of recent evidences |
| topic | Breast cancer Cross-talk ER PR RTKs |
| url | http://www.sciencedirect.com/science/article/pii/S2589936824000562 |
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