Key predictors of long-term outcomes in BCMA-targeted CAR-T therapy for relapsed/refractory multiple myeloma

Key predictors of long-term outcomes in BCMA-targeted CAR-T therapy for relapsed/refractory multiple myeloma

Abstract Background B-cell maturation antigen (BCMA)-directed chimeric antigen receptor T-cell (CAR-T) therapy exhibits high response rates in patients with relapsed/refractory multiple myeloma (r/r MM). However, the specific factors that influence the response duration remain poorly understood. Met...

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Bibliographic Details
Main Authors: Ning An, Juan Li, Pan Luo, Di Wang, Peiling Zhang, Chang Shu, Songbai Cai, Qiuxia Yu, Xinyu Wen, Xinran Wang, Wei Mu, Jianlin Hu, Chunrui Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
R/R multiple myeloma
BCMA CAR-T
MRD
CAR-T cell
Online Access:https://doi.org/10.1186/s12967-025-06543-x
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