NK cell activity in the tumor microenvironment
The formation of an immunosuppressive tumor microenvironment (TME) impairs natural killer (NK) cell infiltration and persistence within tumor tissue and significantly diminishes NK-mediated cytotoxicity. This presents a substantial barrier to the efficacy of NK cell therapy in solid tumors. Current...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1609479/full |
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| author | A. V. Kuznetsova A. V. Kuznetsova X. A. Glukhova I. P. Beletsky A. A. Ivanov |
| author_facet | A. V. Kuznetsova A. V. Kuznetsova X. A. Glukhova I. P. Beletsky A. A. Ivanov |
| author_sort | A. V. Kuznetsova |
| collection | DOAJ |
| description | The formation of an immunosuppressive tumor microenvironment (TME) impairs natural killer (NK) cell infiltration and persistence within tumor tissue and significantly diminishes NK-mediated cytotoxicity. This presents a substantial barrier to the efficacy of NK cell therapy in solid tumors. Current strategies aim to overcome immune evasion by enhancing NK cell recognition and cytotoxicity, while promoting their persistence, infiltration, and resistance to the TME. This review focusses on the biophysical characteristics of TME and specific components of the extracellular matrix (ECM) that affect NK cell activity, with the goal of identifying therapeutic approaches to modulate the TME and create a supportive niche for adaptive immune cell function. Advancements in interdisciplinary collaborations integrating oncology, cell biology, physics, engineering, materials science, and nanotechnology are crucial in advancing therapeutic strategies targeting ECM rigidity and mechanotransduction signaling pathways. |
| format | Article |
| id | doaj-art-45af75bd2cf64d1da2a5df8e20b5adde |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-45af75bd2cf64d1da2a5df8e20b5adde2025-08-20T02:17:08ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-05-011310.3389/fcell.2025.16094791609479NK cell activity in the tumor microenvironmentA. V. Kuznetsova0A. V. Kuznetsova1X. A. Glukhova2I. P. Beletsky3A. A. Ivanov4Laboratory of Molecular and Cellular Pathology, Russian University of Medicine, Ministry of Health of the Russian Federation, Moscow, RussiaLaboratory of Regenerative Biology, Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, RussiaOnni Biotechnologies Ltd., Helsinki, FinlandOnni Biotechnologies Ltd., Helsinki, FinlandLaboratory of Molecular and Cellular Pathology, Russian University of Medicine, Ministry of Health of the Russian Federation, Moscow, RussiaThe formation of an immunosuppressive tumor microenvironment (TME) impairs natural killer (NK) cell infiltration and persistence within tumor tissue and significantly diminishes NK-mediated cytotoxicity. This presents a substantial barrier to the efficacy of NK cell therapy in solid tumors. Current strategies aim to overcome immune evasion by enhancing NK cell recognition and cytotoxicity, while promoting their persistence, infiltration, and resistance to the TME. This review focusses on the biophysical characteristics of TME and specific components of the extracellular matrix (ECM) that affect NK cell activity, with the goal of identifying therapeutic approaches to modulate the TME and create a supportive niche for adaptive immune cell function. Advancements in interdisciplinary collaborations integrating oncology, cell biology, physics, engineering, materials science, and nanotechnology are crucial in advancing therapeutic strategies targeting ECM rigidity and mechanotransduction signaling pathways.https://www.frontiersin.org/articles/10.3389/fcell.2025.1609479/fullhuman natural killer cellstumor microenvironmentextracellular matrixnew targetsanti-NK cell signaling |
| spellingShingle | A. V. Kuznetsova A. V. Kuznetsova X. A. Glukhova I. P. Beletsky A. A. Ivanov NK cell activity in the tumor microenvironment Frontiers in Cell and Developmental Biology human natural killer cells tumor microenvironment extracellular matrix new targets anti-NK cell signaling |
| title | NK cell activity in the tumor microenvironment |
| title_full | NK cell activity in the tumor microenvironment |
| title_fullStr | NK cell activity in the tumor microenvironment |
| title_full_unstemmed | NK cell activity in the tumor microenvironment |
| title_short | NK cell activity in the tumor microenvironment |
| title_sort | nk cell activity in the tumor microenvironment |
| topic | human natural killer cells tumor microenvironment extracellular matrix new targets anti-NK cell signaling |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1609479/full |
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