Do Critically Ill Patients Undergoing Continuous Renal Replacement Therapy Require Ceftaroline Dosage Adjustments? Ceftaroline PopPK Model and Dosage Simulations with the Probability of Target Attainment Analysis Based on Retrospective Data

Do Critically Ill Patients Undergoing Continuous Renal Replacement Therapy Require Ceftaroline Dosage Adjustments? Ceftaroline PopPK Model and Dosage Simulations with the Probability of Target Attainment Analysis Based on Retrospective Data

<b>Objectives</b>: We aimed to develop a population pharmacokinetic (PopPK) model and evaluate dosing regimens for different renal clearances and continuous renal replacement therapy (CRRT) settings. <b>Methods</b>: Data were collected from four studies in intensive care unit...

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Main Authors: Arkadiusz Adamiszak, Krzysztof Pietrzkiewicz, Alicja Bartkowska-Śniatkowska, Piotr Smuszkiewicz, Krzysztof Kusza, Edmund Grześkowiak, Agnieszka Bienert
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Antibiotics
Subjects:
ceftaroline
continuous renal replacement therapy
population pharmacokinetics
Monte Carlo simulations
probability of target attainment
intensive care unit
Online Access:https://www.mdpi.com/2079-6382/14/4/347
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