Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review
Background: Post-viral olfactory dysfunction (PVOD) is the common symptoms of long COVID, lacking of effective treatments. Traditional Chinese medicine (TCM) is claimed to be effective in treating olfactory dysfunction, but the evidence has not yet been critically appraised. We conducted a systemati...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Integrative Medicine Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213422024000258 |
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| author | Xiang-yun Zou Xue-han Liu Chun-li Lu Xin-yan Jin Bai-xiang He Yi-lei Liao Ting Liu Yi-dan Dai Shi-hao Qi Zhu-jun Sheng Zhan-feng Yan Guo-Yan Yang Trine Stub Jian-ping Liu |
| author_facet | Xiang-yun Zou Xue-han Liu Chun-li Lu Xin-yan Jin Bai-xiang He Yi-lei Liao Ting Liu Yi-dan Dai Shi-hao Qi Zhu-jun Sheng Zhan-feng Yan Guo-Yan Yang Trine Stub Jian-ping Liu |
| author_sort | Xiang-yun Zou |
| collection | DOAJ |
| description | Background: Post-viral olfactory dysfunction (PVOD) is the common symptoms of long COVID, lacking of effective treatments. Traditional Chinese medicine (TCM) is claimed to be effective in treating olfactory dysfunction, but the evidence has not yet been critically appraised. We conducted a systematic review to evaluate the effectiveness and safety of TCM for PVOD. Methods: We searched eight databases to identified clinical controlled studies about TCM for PVOD. The Cochrane risk of bias tools and GRADE were used to evaluate the quality of evidence. Risk ratio (RR), mean differences (MD), and 95 % confidence interval (CI), were used for effect estimation and RevMan 5.4.1 was used for data analysis. Results: Six randomized controlled trials (RCTs) (545 participants), two non-randomized controlled trials (non-RCTs) (112 participants), and one retrospective cohort study (30 participants) were included. The overall quality of included studies was low. Acupuncture (n = 8) and acupoint injection (n = 3) were the mainly used TCM therapies. Five RCTs showed a better effect in TCM group. Four trials used acupuncture, and three trials used acupoint injection. The results of two non-RCTs and one cohort study were not statistically significant. Two trials reported mild to moderate adverse events (pain and brief syncope caused by acupuncture or acupoint injection). Conclusions: Limited evidence focus on acupuncture and acupoint injection for PVOD and suggests that acupuncture and acupoint injection may be effective in improving PVOD. More well-designed trials should focus on acupuncture to confirm the benefit. Protocol registration: The protocol of this review was registered at PROSPERO: CRD42022366776. |
| format | Article |
| id | doaj-art-459e784d6b984d2c913bbaca09ab63e5 |
| institution | OA Journals |
| issn | 2213-4220 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Integrative Medicine Research |
| spelling | doaj-art-459e784d6b984d2c913bbaca09ab63e52025-08-20T02:17:50ZengElsevierIntegrative Medicine Research2213-42202024-06-0113210104510.1016/j.imr.2024.101045Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic reviewXiang-yun Zou0Xue-han Liu1Chun-li Lu2Xin-yan Jin3Bai-xiang He4Yi-lei Liao5Ting Liu6Yi-dan Dai7Shi-hao Qi8Zhu-jun Sheng9Zhan-feng Yan10Guo-Yan Yang11Trine Stub12Jian-ping Liu13Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaGuangdong Pharmaceutical University, 280 Huandong Road, University Town, Guangzhou, Guangdong, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Department of Gastroenterology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Guanganmen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Beijing Hospital of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Beijing Hospital of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, ChinaCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Otolaryngology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaNICM Health Research Institute, Western Sydney University, Penrith, NSW, AustraliaThe National Research Center in Complementary and Alternative Medicine (NAFKAM), Department of Community Medicine, Faculty of Health Science, UiT The Arctic University of Norway, Tromsø, NorwayCentre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China; The National Research Center in Complementary and Alternative Medicine (NAFKAM), Department of Community Medicine, Faculty of Health Science, UiT The Arctic University of Norway, Tromsø, Norway; Corresponding author at: Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.Background: Post-viral olfactory dysfunction (PVOD) is the common symptoms of long COVID, lacking of effective treatments. Traditional Chinese medicine (TCM) is claimed to be effective in treating olfactory dysfunction, but the evidence has not yet been critically appraised. We conducted a systematic review to evaluate the effectiveness and safety of TCM for PVOD. Methods: We searched eight databases to identified clinical controlled studies about TCM for PVOD. The Cochrane risk of bias tools and GRADE were used to evaluate the quality of evidence. Risk ratio (RR), mean differences (MD), and 95 % confidence interval (CI), were used for effect estimation and RevMan 5.4.1 was used for data analysis. Results: Six randomized controlled trials (RCTs) (545 participants), two non-randomized controlled trials (non-RCTs) (112 participants), and one retrospective cohort study (30 participants) were included. The overall quality of included studies was low. Acupuncture (n = 8) and acupoint injection (n = 3) were the mainly used TCM therapies. Five RCTs showed a better effect in TCM group. Four trials used acupuncture, and three trials used acupoint injection. The results of two non-RCTs and one cohort study were not statistically significant. Two trials reported mild to moderate adverse events (pain and brief syncope caused by acupuncture or acupoint injection). Conclusions: Limited evidence focus on acupuncture and acupoint injection for PVOD and suggests that acupuncture and acupoint injection may be effective in improving PVOD. More well-designed trials should focus on acupuncture to confirm the benefit. Protocol registration: The protocol of this review was registered at PROSPERO: CRD42022366776.http://www.sciencedirect.com/science/article/pii/S2213422024000258Post-viral olfactory dysfunctionHyposmiaAnosmiaAcupunctureLong COVID |
| spellingShingle | Xiang-yun Zou Xue-han Liu Chun-li Lu Xin-yan Jin Bai-xiang He Yi-lei Liao Ting Liu Yi-dan Dai Shi-hao Qi Zhu-jun Sheng Zhan-feng Yan Guo-Yan Yang Trine Stub Jian-ping Liu Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review Integrative Medicine Research Post-viral olfactory dysfunction Hyposmia Anosmia Acupuncture Long COVID |
| title | Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review |
| title_full | Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review |
| title_fullStr | Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review |
| title_full_unstemmed | Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review |
| title_short | Traditional Chinese medicine for post-viral olfactory dysfunction: A systematic review |
| title_sort | traditional chinese medicine for post viral olfactory dysfunction a systematic review |
| topic | Post-viral olfactory dysfunction Hyposmia Anosmia Acupuncture Long COVID |
| url | http://www.sciencedirect.com/science/article/pii/S2213422024000258 |
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