Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort study
Abstract The aim of this study was to investigate the correlation between lactate-albumin ratio (LAR) and 28-day mortality in patients with sepsis combined with acute kidney failure (SA-AKI). The study was based on the eICU database and collected data from 1855 patients with SA-AKI. The relationship...
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-94753-0 |
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| author | Huizhen Tang Mingli Qu Miaomiao Xin Tongqiang He |
| author_facet | Huizhen Tang Mingli Qu Miaomiao Xin Tongqiang He |
| author_sort | Huizhen Tang |
| collection | DOAJ |
| description | Abstract The aim of this study was to investigate the correlation between lactate-albumin ratio (LAR) and 28-day mortality in patients with sepsis combined with acute kidney failure (SA-AKI). The study was based on the eICU database and collected data from 1855 patients with SA-AKI. The relationship between LAR and 28-day in-hospital mortality was assessed using multivariate Cox regression models and Kaplan-Meier survival analysis. A generalised summation model was also used to analyse the non-linear relationship between LAR and mortality. The results showed that the 28-day in-hospital mortality rate of the patients was 19.46% (361/1,855), with a significant positive correlation between LAR and mortality (HR: 1.26, 95% CI: 1.18–1.35, p < 0.001). The Kaplan-Meier survival curve showed that the highest quartile of LAR (Q4) had the lowest survival rate. Non-linear analysis showed that when the LAR ratio was less than 2.1, mortality increased with each 1-unit increase in the LAR ratio, with an adjusted hazard ratio of 1.48 (95% CI 1.20, 1.84, p < 0.001). For patients with SA-AKI, a nonlinear relationship between LAR and 28-day risk of death was observed, with higher LAR associated with higher risk of mortality. |
| format | Article |
| id | doaj-art-459a03bcc9ec4c848e216e2485412d50 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-459a03bcc9ec4c848e216e2485412d502025-08-20T02:10:21ZengNature PortfolioScientific Reports2045-23222025-03-0115111110.1038/s41598-025-94753-0Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort studyHuizhen Tang0Mingli Qu1Miaomiao Xin2Tongqiang He3Department of Transfusion, Northwest Women’s and Children’s HospitalDepartment of Transfusion, Northwest Women’s and Children’s HospitalReproductive Center, Northwest Women’s and Children’s HospitalObstetrics and Gynecology Intensive Care Unit, Northwest Women’s and Children’s HospitalAbstract The aim of this study was to investigate the correlation between lactate-albumin ratio (LAR) and 28-day mortality in patients with sepsis combined with acute kidney failure (SA-AKI). The study was based on the eICU database and collected data from 1855 patients with SA-AKI. The relationship between LAR and 28-day in-hospital mortality was assessed using multivariate Cox regression models and Kaplan-Meier survival analysis. A generalised summation model was also used to analyse the non-linear relationship between LAR and mortality. The results showed that the 28-day in-hospital mortality rate of the patients was 19.46% (361/1,855), with a significant positive correlation between LAR and mortality (HR: 1.26, 95% CI: 1.18–1.35, p < 0.001). The Kaplan-Meier survival curve showed that the highest quartile of LAR (Q4) had the lowest survival rate. Non-linear analysis showed that when the LAR ratio was less than 2.1, mortality increased with each 1-unit increase in the LAR ratio, with an adjusted hazard ratio of 1.48 (95% CI 1.20, 1.84, p < 0.001). For patients with SA-AKI, a nonlinear relationship between LAR and 28-day risk of death was observed, with higher LAR associated with higher risk of mortality.https://doi.org/10.1038/s41598-025-94753-0 |
| spellingShingle | Huizhen Tang Mingli Qu Miaomiao Xin Tongqiang He Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort study Scientific Reports |
| title | Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort study |
| title_full | Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort study |
| title_fullStr | Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort study |
| title_full_unstemmed | Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort study |
| title_short | Association between lactate-albumin ratio and 28-day mortality in patients with sepsis-associated acute kidney injury: a retrospective cohort study |
| title_sort | association between lactate albumin ratio and 28 day mortality in patients with sepsis associated acute kidney injury a retrospective cohort study |
| url | https://doi.org/10.1038/s41598-025-94753-0 |
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