Direct Consideration of Process History During Intensified Design of Experiments Planning Eases Interpretation of Mammalian Cell Culture Dynamics

Direct Consideration of Process History During Intensified Design of Experiments Planning Eases Interpretation of Mammalian Cell Culture Dynamics

Intra-experimental factor setting shifts in intensified design of experiments (iDoE) enhance understanding of bioproduction processes by capturing their dynamics and are thus essential to fulfill quality by design (QbD) ambitions. Determining the influence of process history on the cellular response...

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Bibliographic Details
Main Authors:	Samuel Kienzle, Lisa Junghans, Stefan Wieschalka, Katharina Diem, Ralf Takors, Nicole Erika Radde, Marco Kunzelmann, Beate Presser, Verena Nold
Format:	Article
Language:	English
Published:	MDPI AG 2025-03-01
Series:	Bioengineering
Subjects:	statistical design of experiment quality by design mammalian bioprocess dynamics dynamic process optimization shifted factor settings
Online Access:	https://www.mdpi.com/2306-5354/12/3/319
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