IFT20 regulates TFEB-dependent lytic granule biogenesis in cytotoxic T lymphocytes by orchestrating the MPR-dependent transport of granzyme B

IFT20 regulates TFEB-dependent lytic granule biogenesis in cytotoxic T lymphocytes by orchestrating the MPR-dependent transport of granzyme B

Abstract Cytotoxic T lymphocytes (CTL) exploit specialized secretory lysosomes, the lytic granules (LG) to kill target cells. The LGs carry a battery of apoptosis-inducing molecules enriched in granzymes (GZM), perforin and FasL, which are released at the immune synapse formed by CTLs with their cog...

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Main Authors: Francesca Finetti, Fabrizia Zevolini, Loredana Migliore, Valentina Cianfanelli, Leandro Marzuoli, Nagaja Capitani, Chiara Cassioli, Laura Patrussi, Cristina Ulivieri, Giuseppe Marotta, Cosima T. Baldari
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07727-5
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