Evaluation of irisin levels and lipid profiles in obese men with type 2 diabetes mellitus
Background. Diabetes mellitus (DM) represents a global health problem as a result of lifestyle changes, represented by altered dietary habits and the city life that community members live, as well as lack of movement. Irisin belongs to the class of muscle-fat kinetics because it works in both fatty...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaslavsky O.Yu.
2025-06-01
|
| Series: | Mìžnarodnij Endokrinologìčnij Žurnal |
| Subjects: | |
| Online Access: | https://iej.zaslavsky.com.ua/index.php/journal/article/view/1568 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background. Diabetes mellitus (DM) represents a global health problem as a result of lifestyle changes, represented by altered dietary habits and the city life that community members live, as well as lack of movement. Irisin belongs to the class of muscle-fat kinetics because it works in both fatty and muscular tissues. It is a thermogenic protein that stimulates energy production and the burning of brown adipose tissue when exercising. The present study purposed to estimate the level of irisin hormone and some biochemical parameters in obese men with type 2 DM, and to determine the relationship of irisin with the level of blood sugar accumulation in men with type 2 DM and obesity, and in healthy people. Materials and methods. The study included collecting 90 blood samples: 60 from men with type 2 DM and obesity, and 30 from unaffected (healthy) men. The samples were divided into two groups based on age of participants: 24–44 and 45–65 years. Each of them included 45 samples (30 from patients and 15 from healthy individuals). Results. The body mass index and serum irisin level of patients with type 2 DM and obesity in both age groups were significantly increased compared to healthy subjects at the probability level of P ≤ 0.05. The results also showed that the glucose concentration and cumulative sugar of patients with type 2 DM and obesity in both age groups were significantly increased compared to healthy subjects at the probability level of P ≤ 0.05. As for the biochemical tests that included lipid profile evaluation, there was a significant increase in total cholesterol, triglycerides, low- and very low-density lipoprotein in the serum of patients with type 2 DM in both age groups compared to healthy people. The concentration of high-density lipoprotein in the serum of patients with type 2 DM and obesity in both age groups decreased significantly compared to healthy people at the probability level of P ≤ 0.05. Conclusions. The current study concluded that serum irisin levels and most lipid profile parameters were elevated in patients with type 2 diabetes and obesity, which may indicate an association between the content of this myokine and lipid profile disorders in men with DM. |
|---|---|
| ISSN: | 2224-0721 2307-1427 |