Carotid intima thickness and elasticity combined with MHR predicting the severity of coronary artery stenosis in patients with premature coronary artery disease
Abstract Background Carotid intima thickness (CIT) and hardness coefficient (HC) are sensitive indicators of structural and functional changes in the carotid arteries in the subclinical stage of atherosclerosis. The monocyte to high-density lipoprotein cholesterol ratio (MHR), which is a biomarker o...
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2025-04-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04693-w |
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| author | Chenjing Xu Ming Wu Xijun Zhang Kaikai Shen Yanyan Guo Jianjun Yuan Haohui Zhu |
| author_facet | Chenjing Xu Ming Wu Xijun Zhang Kaikai Shen Yanyan Guo Jianjun Yuan Haohui Zhu |
| author_sort | Chenjing Xu |
| collection | DOAJ |
| description | Abstract Background Carotid intima thickness (CIT) and hardness coefficient (HC) are sensitive indicators of structural and functional changes in the carotid arteries in the subclinical stage of atherosclerosis. The monocyte to high-density lipoprotein cholesterol ratio (MHR), which is a biomarker of inflammation, has been shown to correlate with cardiovascular disease. The aim of this study was to assess the predictive value of CIT and HC with MHR in determining the severity of coronary artery stenosis in patients with premature coronary artery disease (PCAD). Methods This prospective study included 85 PCAD patients who underwent coronary angiography. Patients were categorized into high-score (42 cases) and low-score (43 cases) groups based on the median Gensini score. Additionally, 41 volunteers matched by body mass index (BMI), age, and gender served as a control group. CIT, carotid media thickness (CMT) and carotid intima-media thickness (CIMT) were measured using a 24 MHz ultra-high frequency ultrasound probe. Diameter (Diam), distance (Dist), pulse wave velocity (PWV), and HC were evaluated through RF-data based quantitative analysis on vessel stiffness. Binary logistic regression identified risk factors influencing the severity of coronary artery stenosis. Receiver operating characteristic curves were plotted to evaluate the diagnostic performance of CIT, HC, and MHR, both individually and in combination, for predicting coronary artery stenosis severity in PCAD patients. Results CIT, HC and MHR were significantly higher in the high group than in the low and control groups. CIT (AUC = 0.731, 95%CI: 0.624–0.838, P < 0.001) and HC (AUC = 0.783, 95%CI: 0.683–0.882, P < 0.001) individually demonstrated good diagnostic performance in assessing the severity of coronary artery stenosis, with the combined use of carotid parameters and MHR achieving the highest diagnostic efficacy (AUC = 0.849, 95%CI: 0.770–0.929, P < 0.001). Conclusion Patients in the high group had elevated CIT, CIT/CMT, and HC compared to those in the low group. Combining CIT and HC with MHR demonstrated high efficacy in predicting coronary artery stenosis severity in PCAD patients. |
| format | Article |
| id | doaj-art-45854c3e58a845de8ea672f56dd9ed48 |
| institution | DOAJ |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-45854c3e58a845de8ea672f56dd9ed482025-08-20T03:04:59ZengBMCBMC Cardiovascular Disorders1471-22612025-04-0125111010.1186/s12872-025-04693-wCarotid intima thickness and elasticity combined with MHR predicting the severity of coronary artery stenosis in patients with premature coronary artery diseaseChenjing Xu0Ming Wu1Xijun Zhang2Kaikai Shen3Yanyan Guo4Jianjun Yuan5Haohui Zhu6Department of Ultrasound, Zhengzhou University People’s HospitalDepartment of Ultrasound, Henan Provincial People’s HospitalDepartment of Ultrasound, Henan Provincial People’s HospitalDepartment of Ultrasound, Henan Provincial People’s HospitalDepartment of Ultrasound, Henan Provincial People’s HospitalDepartment of Ultrasound, Henan Provincial People’s HospitalDepartment of Ultrasound, Henan Provincial People’s HospitalAbstract Background Carotid intima thickness (CIT) and hardness coefficient (HC) are sensitive indicators of structural and functional changes in the carotid arteries in the subclinical stage of atherosclerosis. The monocyte to high-density lipoprotein cholesterol ratio (MHR), which is a biomarker of inflammation, has been shown to correlate with cardiovascular disease. The aim of this study was to assess the predictive value of CIT and HC with MHR in determining the severity of coronary artery stenosis in patients with premature coronary artery disease (PCAD). Methods This prospective study included 85 PCAD patients who underwent coronary angiography. Patients were categorized into high-score (42 cases) and low-score (43 cases) groups based on the median Gensini score. Additionally, 41 volunteers matched by body mass index (BMI), age, and gender served as a control group. CIT, carotid media thickness (CMT) and carotid intima-media thickness (CIMT) were measured using a 24 MHz ultra-high frequency ultrasound probe. Diameter (Diam), distance (Dist), pulse wave velocity (PWV), and HC were evaluated through RF-data based quantitative analysis on vessel stiffness. Binary logistic regression identified risk factors influencing the severity of coronary artery stenosis. Receiver operating characteristic curves were plotted to evaluate the diagnostic performance of CIT, HC, and MHR, both individually and in combination, for predicting coronary artery stenosis severity in PCAD patients. Results CIT, HC and MHR were significantly higher in the high group than in the low and control groups. CIT (AUC = 0.731, 95%CI: 0.624–0.838, P < 0.001) and HC (AUC = 0.783, 95%CI: 0.683–0.882, P < 0.001) individually demonstrated good diagnostic performance in assessing the severity of coronary artery stenosis, with the combined use of carotid parameters and MHR achieving the highest diagnostic efficacy (AUC = 0.849, 95%CI: 0.770–0.929, P < 0.001). Conclusion Patients in the high group had elevated CIT, CIT/CMT, and HC compared to those in the low group. Combining CIT and HC with MHR demonstrated high efficacy in predicting coronary artery stenosis severity in PCAD patients.https://doi.org/10.1186/s12872-025-04693-wUltra-high frequency ultrasoundPremature coronary artery diseaseCarotid intima thicknessCarotid artery elasticityMonocyte to high-density lipoprotein cholesterol ratioSeverity of coronary artery stenosis |
| spellingShingle | Chenjing Xu Ming Wu Xijun Zhang Kaikai Shen Yanyan Guo Jianjun Yuan Haohui Zhu Carotid intima thickness and elasticity combined with MHR predicting the severity of coronary artery stenosis in patients with premature coronary artery disease BMC Cardiovascular Disorders Ultra-high frequency ultrasound Premature coronary artery disease Carotid intima thickness Carotid artery elasticity Monocyte to high-density lipoprotein cholesterol ratio Severity of coronary artery stenosis |
| title | Carotid intima thickness and elasticity combined with MHR predicting the severity of coronary artery stenosis in patients with premature coronary artery disease |
| title_full | Carotid intima thickness and elasticity combined with MHR predicting the severity of coronary artery stenosis in patients with premature coronary artery disease |
| title_fullStr | Carotid intima thickness and elasticity combined with MHR predicting the severity of coronary artery stenosis in patients with premature coronary artery disease |
| title_full_unstemmed | Carotid intima thickness and elasticity combined with MHR predicting the severity of coronary artery stenosis in patients with premature coronary artery disease |
| title_short | Carotid intima thickness and elasticity combined with MHR predicting the severity of coronary artery stenosis in patients with premature coronary artery disease |
| title_sort | carotid intima thickness and elasticity combined with mhr predicting the severity of coronary artery stenosis in patients with premature coronary artery disease |
| topic | Ultra-high frequency ultrasound Premature coronary artery disease Carotid intima thickness Carotid artery elasticity Monocyte to high-density lipoprotein cholesterol ratio Severity of coronary artery stenosis |
| url | https://doi.org/10.1186/s12872-025-04693-w |
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