Glymphatic dysfunction assessed by DTI-ALPS index predicts early cognitive impairment in acute subcortical infarcts: a prospective clinical cohort study

Glymphatic dysfunction assessed by DTI-ALPS index predicts early cognitive impairment in acute subcortical infarcts: a prospective clinical cohort study

BackgroundThe glymphatic system (GS), responsible for clearing neurotoxic proteins (such as β-amyloid and tau protein), is critical in stroke pathophysiology. However, its role in acute post-stroke cognitive impairment (PSCI) remains unclear. We investigated GS dysfunction via the DTI-ALPS index in...

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Bibliographic Details
Main Authors: Yirong Wang, Mei Yang, Xingmao Zeng, Shuai Wang, Wenmin Zhang, Weidong Wang, Yang Du, Jurong Ding, Xin Ding
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Neurology
Subjects:
glymphatic system
DTI-ALPS
subcortical infarction
cognitive impairment
diffusion tensor imaging
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2025.1605889/full
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