Advanced capabilities for in vitro stress diagnostics: a review
INTRODUCTION. The effects of stress negatively affect both physical and mental health. Recently, there has been a sharp increase in interest in studying evidence-based methods for diagnosing stress and effective interventions for its correction. AIM. Comprehensive assessment of modern possibiliti...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Ministry of Health of the Russian Federation. National Medical Research Center of Rehabilitation and Balneology
2025-02-01
|
| Series: | Вестник восстановительной медицины |
| Subjects: | |
| Online Access: | https://journals.eco-vector.com/2078-1962/article/viewFile/641812/pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849344565683683328 |
|---|---|
| author | Yana G. Pekhova Anna A. Kuzyukova Larisa A. Marchenkova |
| author_facet | Yana G. Pekhova Anna A. Kuzyukova Larisa A. Marchenkova |
| author_sort | Yana G. Pekhova |
| collection | DOAJ |
| description | INTRODUCTION. The effects of stress negatively affect both physical and mental health. Recently, there has been a sharp increase in interest in studying evidence-based methods for diagnosing stress and effective interventions for its correction.
AIM. Comprehensive assessment of modern possibilities of stress objectification using laboratory diagnostics of its markers based on data from literary sources.
MATERIALS AND METHODS. To select publications, we studied the PubMed, Web of Science (Web of Science Core Collection and Medline), Cochrane Library databases, included data from meta-analyses and review articles, full-text articles investigating the relationship between laboratory biomarkers and stress. The search depth of publications was 10 years, from 2014 to 2024, and a number of earlier, fundamental works on the neurophysiology of stress were also included in the review.
RESULTS AND DISCUSSION. The biological basis of stress manifestations is a growing area of interest for scientists, as evidenced by the increasing number of publications on cortisol and dehydroepiandrosterone (DHEA) over the past 10 years. The review reflects a modern view on the role of laboratory markers in stress diagnostics. Biomarkers such as cortisol (the level of the surge after awakening, the average level of cortisol during the day, the daily curve of cortisol, cortisol in the hair), salivary alpha-amylase, DHEA, etc. are described, information on their sensitivity and specificity in the verification of acute and chronic stress conditions is analyzed.
CONCLUSION. Cortisol is the most reliable and frequently used laboratory marker of both acute and chronic stress, while the study of other potential biomarkers continues to grow. Psychometric questionnaires and functional diagnostic methods reflecting the degree of sympathetic activation are widely used in stress diagnostics. The integrated use of various diagnostic tools, including laboratory biomarkers of stress, will provide a multimodal approach, will contribute to a more complete picture of the stress response and will increase the degree of verification of stress conditions. |
| format | Article |
| id | doaj-art-457489d5b01b4cd2a582931279943ccd |
| institution | Kabale University |
| issn | 2078-1962 2713-2625 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Ministry of Health of the Russian Federation. National Medical Research Center of Rehabilitation and Balneology |
| record_format | Article |
| series | Вестник восстановительной медицины |
| spelling | doaj-art-457489d5b01b4cd2a582931279943ccd2025-08-20T03:42:38ZengMinistry of Health of the Russian Federation. National Medical Research Center of Rehabilitation and BalneologyВестник восстановительной медицины2078-19622713-26252025-02-01241677410.38025/2078-1962-2025-24-1-67-741459Advanced capabilities for in vitro stress diagnostics: a reviewYana G. Pekhova0https://orcid.org/0000-0002-2754-1021Anna A. Kuzyukova1https://orcid.org/0000-0002-9275-6491Larisa A. Marchenkova2https://orcid.org/0000-0003-1886-124XNational Medical Research Center for Rehabilitation and BalneologyNational Medical Research Center for Rehabilitation and BalneologyNational Medical Research Center for Rehabilitation and BalneologyINTRODUCTION. The effects of stress negatively affect both physical and mental health. Recently, there has been a sharp increase in interest in studying evidence-based methods for diagnosing stress and effective interventions for its correction. AIM. Comprehensive assessment of modern possibilities of stress objectification using laboratory diagnostics of its markers based on data from literary sources. MATERIALS AND METHODS. To select publications, we studied the PubMed, Web of Science (Web of Science Core Collection and Medline), Cochrane Library databases, included data from meta-analyses and review articles, full-text articles investigating the relationship between laboratory biomarkers and stress. The search depth of publications was 10 years, from 2014 to 2024, and a number of earlier, fundamental works on the neurophysiology of stress were also included in the review. RESULTS AND DISCUSSION. The biological basis of stress manifestations is a growing area of interest for scientists, as evidenced by the increasing number of publications on cortisol and dehydroepiandrosterone (DHEA) over the past 10 years. The review reflects a modern view on the role of laboratory markers in stress diagnostics. Biomarkers such as cortisol (the level of the surge after awakening, the average level of cortisol during the day, the daily curve of cortisol, cortisol in the hair), salivary alpha-amylase, DHEA, etc. are described, information on their sensitivity and specificity in the verification of acute and chronic stress conditions is analyzed. CONCLUSION. Cortisol is the most reliable and frequently used laboratory marker of both acute and chronic stress, while the study of other potential biomarkers continues to grow. Psychometric questionnaires and functional diagnostic methods reflecting the degree of sympathetic activation are widely used in stress diagnostics. The integrated use of various diagnostic tools, including laboratory biomarkers of stress, will provide a multimodal approach, will contribute to a more complete picture of the stress response and will increase the degree of verification of stress conditions.https://journals.eco-vector.com/2078-1962/article/viewFile/641812/pdfstresschronic stressbiomarkerscortisolsalivary cortisolurinary cortisolhair cortisolsalivary alpha-amylasedehydroepiandrosteronesympathetic-adrenal systemhypothalamic-pituitary-adrenal axis |
| spellingShingle | Yana G. Pekhova Anna A. Kuzyukova Larisa A. Marchenkova Advanced capabilities for in vitro stress diagnostics: a review Вестник восстановительной медицины stress chronic stress biomarkers cortisol salivary cortisol urinary cortisol hair cortisol salivary alpha-amylase dehydroepiandrosterone sympathetic-adrenal system hypothalamic-pituitary-adrenal axis |
| title | Advanced capabilities for in vitro stress diagnostics: a review |
| title_full | Advanced capabilities for in vitro stress diagnostics: a review |
| title_fullStr | Advanced capabilities for in vitro stress diagnostics: a review |
| title_full_unstemmed | Advanced capabilities for in vitro stress diagnostics: a review |
| title_short | Advanced capabilities for in vitro stress diagnostics: a review |
| title_sort | advanced capabilities for in vitro stress diagnostics a review |
| topic | stress chronic stress biomarkers cortisol salivary cortisol urinary cortisol hair cortisol salivary alpha-amylase dehydroepiandrosterone sympathetic-adrenal system hypothalamic-pituitary-adrenal axis |
| url | https://journals.eco-vector.com/2078-1962/article/viewFile/641812/pdf |
| work_keys_str_mv | AT yanagpekhova advancedcapabilitiesforinvitrostressdiagnosticsareview AT annaakuzyukova advancedcapabilitiesforinvitrostressdiagnosticsareview AT larisaamarchenkova advancedcapabilitiesforinvitrostressdiagnosticsareview |