Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease
Alzheimer’s disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins. Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene i...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2018/6392986 |
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| _version_ | 1832550690059190272 |
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| author | Kyeong-Ah Kwak Seung-Pyo Lee Jin-Young Yang Young-Seok Park |
| author_facet | Kyeong-Ah Kwak Seung-Pyo Lee Jin-Young Yang Young-Seok Park |
| author_sort | Kyeong-Ah Kwak |
| collection | DOAJ |
| description | Alzheimer’s disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins. Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene in the disease’s pathogenesis. Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy. The results from recent preclinical studies regarding stem cell-based therapies are promising. Human clinical trials are now underway. However, a number of questions remain to be answered prior to safe and effective clinical translation. This review explores the pathophysiology of AD and summarizes the relevant stem cell research according to cell type. We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications. |
| format | Article |
| id | doaj-art-45745647cad847569f9551125755cf35 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-45745647cad847569f9551125755cf352025-02-03T06:05:59ZengWileyStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/63929866392986Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s DiseaseKyeong-Ah Kwak0Seung-Pyo Lee1Jin-Young Yang2Young-Seok Park3Department of Oral Anatomy, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of KoreaDepartment of Oral Anatomy, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of KoreaDepartment of Dental Hygiene, Daejeon Institute of Science and Technology, Daejeon, Republic of KoreaDepartment of Oral Anatomy, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of KoreaAlzheimer’s disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins. Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene in the disease’s pathogenesis. Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy. The results from recent preclinical studies regarding stem cell-based therapies are promising. Human clinical trials are now underway. However, a number of questions remain to be answered prior to safe and effective clinical translation. This review explores the pathophysiology of AD and summarizes the relevant stem cell research according to cell type. We also briefly summarize related clinical trials. Finally, future perspectives are discussed with regard to their clinical applications.http://dx.doi.org/10.1155/2018/6392986 |
| spellingShingle | Kyeong-Ah Kwak Seung-Pyo Lee Jin-Young Yang Young-Seok Park Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease Stem Cells International |
| title | Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease |
| title_full | Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease |
| title_fullStr | Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease |
| title_full_unstemmed | Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease |
| title_short | Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease |
| title_sort | current perspectives regarding stem cell based therapy for alzheimer s disease |
| url | http://dx.doi.org/10.1155/2018/6392986 |
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