Transcriptional Factors Related to Cellular Kinetics, Apoptosis, and Tumorigenicity in Equine Adipose-Derived Mesenchymal Stem Cells (ASCs) Are Influenced by the Age of the Donors

Transcriptional Factors Related to Cellular Kinetics, Apoptosis, and Tumorigenicity in Equine Adipose-Derived Mesenchymal Stem Cells (ASCs) Are Influenced by the Age of the Donors

The impact of donor age on Adipose-derived mesenchymal stem cell (ASC) functionality and safety remains insufficiently characterized, particularly in equine models. This study investigates the influence of age on ASCs proliferation dynamics and the expression of tumorigenic and apoptosis-related mar...

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Bibliographic Details
Main Authors: Ekaterina Vachkova, Stefan Arnhold, Valeria Petrova, Manuela Heimann, Tsvetoslav Koynarski, Galina Simeonova, Paskal Piperkov
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Animals
Subjects:
equine ASCs
aging
tumorigenic and apoptotic transcriptional factors
cellular kinetic
Online Access:https://www.mdpi.com/2076-2615/15/13/1910
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