The RNA World: Piecing together the historical development of a hypothesis
The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein synthesis and biochemical reactions took place. As t...
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Universitat de València
2016-04-01
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| Series: | Mètode Science Studies Journal: Annual Review |
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| Online Access: | https://turia.uv.es/index.php/Metode/article/view/5146 |
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| _version_ | 1846164045984432128 |
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| author | Antonio Lazcano |
| author_facet | Antonio Lazcano |
| author_sort | Antonio Lazcano |
| collection | DOAJ |
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The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein synthesis and biochemical reactions took place. As the understanding of RNA biology progressed, several independent proposals of protein-free primordial life forms were suggested. Although this possibility was strongly reinforced with the discovery of ribozymes, there are many definitions of the RNA world, including several contradictory ones. One could say that it was an early, perhaps primordial, stage during which RNA molecules played a much more conspicuous role in heredity and metabolism and, particularly, in the origin and early evolution of protein biosynthesis. The overwhelming evidence for the catalytic, regulatory, and structural properties of RNA molecules, combined with their ubiquity in cellular processes, can only be explained with the proposal that they played a key role in early evolution and perhaps in the origin of life itself.
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| format | Article |
| id | doaj-art-45721bc6e3fb4dd98c96cad2b7915b04 |
| institution | Kabale University |
| issn | 2174-3487 2174-9221 |
| language | Catalan |
| publishDate | 2016-04-01 |
| publisher | Universitat de València |
| record_format | Article |
| series | Mètode Science Studies Journal: Annual Review |
| spelling | doaj-art-45721bc6e3fb4dd98c96cad2b7915b042024-11-18T16:02:44ZcatUniversitat de ValènciaMètode Science Studies Journal: Annual Review2174-34872174-92212016-04-01610.7203/metode.6.5146The RNA World: Piecing together the historical development of a hypothesisAntonio Lazcano0<p>UNAM, Mexico City</p> The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein synthesis and biochemical reactions took place. As the understanding of RNA biology progressed, several independent proposals of protein-free primordial life forms were suggested. Although this possibility was strongly reinforced with the discovery of ribozymes, there are many definitions of the RNA world, including several contradictory ones. One could say that it was an early, perhaps primordial, stage during which RNA molecules played a much more conspicuous role in heredity and metabolism and, particularly, in the origin and early evolution of protein biosynthesis. The overwhelming evidence for the catalytic, regulatory, and structural properties of RNA molecules, combined with their ubiquity in cellular processes, can only be explained with the proposal that they played a key role in early evolution and perhaps in the origin of life itself. https://turia.uv.es/index.php/Metode/article/view/5146Origin of lifeRNA Worldribonucleotidyl coenzymescatalytic RNA |
| spellingShingle | Antonio Lazcano The RNA World: Piecing together the historical development of a hypothesis Mètode Science Studies Journal: Annual Review Origin of life RNA World ribonucleotidyl coenzymes catalytic RNA |
| title | The RNA World: Piecing together the historical development of a hypothesis |
| title_full | The RNA World: Piecing together the historical development of a hypothesis |
| title_fullStr | The RNA World: Piecing together the historical development of a hypothesis |
| title_full_unstemmed | The RNA World: Piecing together the historical development of a hypothesis |
| title_short | The RNA World: Piecing together the historical development of a hypothesis |
| title_sort | rna world piecing together the historical development of a hypothesis |
| topic | Origin of life RNA World ribonucleotidyl coenzymes catalytic RNA |
| url | https://turia.uv.es/index.php/Metode/article/view/5146 |
| work_keys_str_mv | AT antoniolazcano thernaworldpiecingtogetherthehistoricaldevelopmentofahypothesis AT antoniolazcano rnaworldpiecingtogetherthehistoricaldevelopmentofahypothesis |