CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals
CRISPR-Cas9 enables targeted genome editing and has become a pivotal tool in biomedical research and animal genome engineering. This review highlights its application in generating genetically modified animals used as preclinical disease models, bioreactors for recombinant protein production, and po...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-05-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/5/330 |
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| _version_ | 1849711110271270912 |
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| author | Wiktoria Urban Marta Kropacz Maksymilian Łach Anna Jankowska |
| author_facet | Wiktoria Urban Marta Kropacz Maksymilian Łach Anna Jankowska |
| author_sort | Wiktoria Urban |
| collection | DOAJ |
| description | CRISPR-Cas9 enables targeted genome editing and has become a pivotal tool in biomedical research and animal genome engineering. This review highlights its application in generating genetically modified animals used as preclinical disease models, bioreactors for recombinant protein production, and potential sources of xenotransplantation organs. We also discuss its role in improving livestock traits, welfare, and breeding efficiency. The benefits and limitations of CRISPR-Cas9 are examined, emphasizing its transformative potential in research and agricultural biotechnology. |
| format | Article |
| id | doaj-art-456be88f2fba4dc28f46938b9f2f0a0e |
| institution | DOAJ |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-456be88f2fba4dc28f46938b9f2f0a0e2025-08-20T03:14:42ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-05-0147533010.3390/cimb47050330CRISPR-Cas9 in the Tailoring of Genetically Engineered AnimalsWiktoria Urban0Marta Kropacz1Maksymilian Łach2Anna Jankowska3Department of Cell Biology, Poznan University of Medical Sciences, 61-701 Poznań, PolandDepartment of Cell Biology, Poznan University of Medical Sciences, 61-701 Poznań, PolandDepartment of Cell Biology, Poznan University of Medical Sciences, 61-701 Poznań, PolandDepartment of Cell Biology, Poznan University of Medical Sciences, 61-701 Poznań, PolandCRISPR-Cas9 enables targeted genome editing and has become a pivotal tool in biomedical research and animal genome engineering. This review highlights its application in generating genetically modified animals used as preclinical disease models, bioreactors for recombinant protein production, and potential sources of xenotransplantation organs. We also discuss its role in improving livestock traits, welfare, and breeding efficiency. The benefits and limitations of CRISPR-Cas9 are examined, emphasizing its transformative potential in research and agricultural biotechnology.https://www.mdpi.com/1467-3045/47/5/330CRISPR-Cas9genome editinggenetically engineered animalsmodel organismsxenotransplantation |
| spellingShingle | Wiktoria Urban Marta Kropacz Maksymilian Łach Anna Jankowska CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals Current Issues in Molecular Biology CRISPR-Cas9 genome editing genetically engineered animals model organisms xenotransplantation |
| title | CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals |
| title_full | CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals |
| title_fullStr | CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals |
| title_full_unstemmed | CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals |
| title_short | CRISPR-Cas9 in the Tailoring of Genetically Engineered Animals |
| title_sort | crispr cas9 in the tailoring of genetically engineered animals |
| topic | CRISPR-Cas9 genome editing genetically engineered animals model organisms xenotransplantation |
| url | https://www.mdpi.com/1467-3045/47/5/330 |
| work_keys_str_mv | AT wiktoriaurban crisprcas9inthetailoringofgeneticallyengineeredanimals AT martakropacz crisprcas9inthetailoringofgeneticallyengineeredanimals AT maksymilianłach crisprcas9inthetailoringofgeneticallyengineeredanimals AT annajankowska crisprcas9inthetailoringofgeneticallyengineeredanimals |