Bladder Adenocarcinoma in a Constellation of Multiple Site Malignancies: An Unusual Case and Systematic Review
Background and Objectives: Multiple primary malignant tumors represent a small percentage of the total number of oncological cases and can involve either metachronous or synchronous development and represent challenges in diagnosis, staging, and treatment planning. Our purpose is to present a rare c...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/14/22/2510 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850144946984583168 |
|---|---|
| author | Daniel Porav-Hodade Raul Gherasim Andrada Loghin Bianca Lazar Ovidiu Simion Cotoi Mihail-Alexandru Badea Mártha Orsolya Katalin Ilona Ciprian Todea-Moga Mihai Dorin Vartolomei Georgescu Rares Nicolae Crisan Ovidiu Bogdan Feciche |
| author_facet | Daniel Porav-Hodade Raul Gherasim Andrada Loghin Bianca Lazar Ovidiu Simion Cotoi Mihail-Alexandru Badea Mártha Orsolya Katalin Ilona Ciprian Todea-Moga Mihai Dorin Vartolomei Georgescu Rares Nicolae Crisan Ovidiu Bogdan Feciche |
| author_sort | Daniel Porav-Hodade |
| collection | DOAJ |
| description | Background and Objectives: Multiple primary malignant tumors represent a small percentage of the total number of oncological cases and can involve either metachronous or synchronous development and represent challenges in diagnosis, staging, and treatment planning. Our purpose is to present a rare case of bladder adenocarcinoma in a female patient with multiple primary malignant tumors and to provide systematic review of the available literature. Materials and Methods: A 67-year-old female patient was admitted with altered general condition and anuria. The past medical history of the patient included malignant melanoma (2014), cervical cancer (2017), colon cancer (2021), obstructive anuria (2023), and liver metastasectomy (2023). Transurethral resection of bladder tumor was performed for bladder tumors. Results: Contrast CT highlighted multiple pulmonary metastases, a poly nodular liver conglomerate, retroperitoneal lymph node, II/III grade left ureterohydronephrosis, and no digestive tract tumor masses. The pathological result of the bladder resection showed an infiltrative adenocarcinoma. Conclusions: The difference between primary bladder adenocarcinoma tumor and metastatic colorectal adenocarcinoma is the key for the future therapeutic strategy. Identification and assessment of risk factors such as viral infection, radiotherapy, chemotherapy, smoking, and genetics are pivotal in understanding and managing multiple primary malignant tumors. Personalized prevention strategies and screening programs may facilitate the early detection of these tumors, whether synchronous or metachronous. The use of multicancer early detection (MCED) blood tests for early diagnosis appears promising. However, additional research is needed to standardize these techniques for cancer detection. |
| format | Article |
| id | doaj-art-4563d1639ed54ad7b46a67cedf021ca7 |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-4563d1639ed54ad7b46a67cedf021ca72025-08-20T02:28:12ZengMDPI AGDiagnostics2075-44182024-11-011422251010.3390/diagnostics14222510Bladder Adenocarcinoma in a Constellation of Multiple Site Malignancies: An Unusual Case and Systematic ReviewDaniel Porav-Hodade0Raul Gherasim1Andrada Loghin2Bianca Lazar3Ovidiu Simion Cotoi4Mihail-Alexandru Badea5Mártha Orsolya Katalin Ilona6Ciprian Todea-Moga7Mihai Dorin Vartolomei8Georgescu Rares9Nicolae Crisan10Ovidiu Bogdan Feciche11Department of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaDepartment of Urology, Clinical County Hospital Mures, 540136 Târgu Mures, RomaniaDepartment of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaDepartment of Pathophysiology, Clinical County Hospital Mures, 540136 Târgu Mures, RomaniaDepartment of Pathophysiology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaDepartment of Dermatology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaDepartment of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaDepartment of Urology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaDepartment of Cell and Molecular Biology, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaDepartment of General Surgery, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Târgu Mureș, 540139 Târgu Mureș, RomaniaDepartment of Urology, Iului Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Urology, Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, RomaniaBackground and Objectives: Multiple primary malignant tumors represent a small percentage of the total number of oncological cases and can involve either metachronous or synchronous development and represent challenges in diagnosis, staging, and treatment planning. Our purpose is to present a rare case of bladder adenocarcinoma in a female patient with multiple primary malignant tumors and to provide systematic review of the available literature. Materials and Methods: A 67-year-old female patient was admitted with altered general condition and anuria. The past medical history of the patient included malignant melanoma (2014), cervical cancer (2017), colon cancer (2021), obstructive anuria (2023), and liver metastasectomy (2023). Transurethral resection of bladder tumor was performed for bladder tumors. Results: Contrast CT highlighted multiple pulmonary metastases, a poly nodular liver conglomerate, retroperitoneal lymph node, II/III grade left ureterohydronephrosis, and no digestive tract tumor masses. The pathological result of the bladder resection showed an infiltrative adenocarcinoma. Conclusions: The difference between primary bladder adenocarcinoma tumor and metastatic colorectal adenocarcinoma is the key for the future therapeutic strategy. Identification and assessment of risk factors such as viral infection, radiotherapy, chemotherapy, smoking, and genetics are pivotal in understanding and managing multiple primary malignant tumors. Personalized prevention strategies and screening programs may facilitate the early detection of these tumors, whether synchronous or metachronous. The use of multicancer early detection (MCED) blood tests for early diagnosis appears promising. However, additional research is needed to standardize these techniques for cancer detection.https://www.mdpi.com/2075-4418/14/22/2510multiple tumorsmalignant melanomaprimary malignanciessecondary malignanciesgenitourinary malignanciesmetachronous |
| spellingShingle | Daniel Porav-Hodade Raul Gherasim Andrada Loghin Bianca Lazar Ovidiu Simion Cotoi Mihail-Alexandru Badea Mártha Orsolya Katalin Ilona Ciprian Todea-Moga Mihai Dorin Vartolomei Georgescu Rares Nicolae Crisan Ovidiu Bogdan Feciche Bladder Adenocarcinoma in a Constellation of Multiple Site Malignancies: An Unusual Case and Systematic Review Diagnostics multiple tumors malignant melanoma primary malignancies secondary malignancies genitourinary malignancies metachronous |
| title | Bladder Adenocarcinoma in a Constellation of Multiple Site Malignancies: An Unusual Case and Systematic Review |
| title_full | Bladder Adenocarcinoma in a Constellation of Multiple Site Malignancies: An Unusual Case and Systematic Review |
| title_fullStr | Bladder Adenocarcinoma in a Constellation of Multiple Site Malignancies: An Unusual Case and Systematic Review |
| title_full_unstemmed | Bladder Adenocarcinoma in a Constellation of Multiple Site Malignancies: An Unusual Case and Systematic Review |
| title_short | Bladder Adenocarcinoma in a Constellation of Multiple Site Malignancies: An Unusual Case and Systematic Review |
| title_sort | bladder adenocarcinoma in a constellation of multiple site malignancies an unusual case and systematic review |
| topic | multiple tumors malignant melanoma primary malignancies secondary malignancies genitourinary malignancies metachronous |
| url | https://www.mdpi.com/2075-4418/14/22/2510 |
| work_keys_str_mv | AT danielporavhodade bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT raulgherasim bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT andradaloghin bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT biancalazar bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT ovidiusimioncotoi bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT mihailalexandrubadea bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT marthaorsolyakatalinilona bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT cipriantodeamoga bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT mihaidorinvartolomei bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT georgescurares bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT nicolaecrisan bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview AT ovidiubogdanfeciche bladderadenocarcinomainaconstellationofmultiplesitemalignanciesanunusualcaseandsystematicreview |