Aging‐induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense

Aging‐induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense

Abstract Older individuals experience increased susceptibility and mortality to bacterial infections, but the underlying etiology remains unclear. Herein, it is shown that aging‐associated reduction of commensal Parabacteroides goldsteinii (P. goldsteinii) in both aged mice and humans critically con...

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Main Authors: Peng Gu, Rongjuan Wei, Ruofan Liu, Qin Yang, Yuxuan He, Jianbin Guan, Wenhao He, Jiaxin Li, Yunfei Zhao, Li Xie, Jie He, Qingling Guo, Jiajia Hu, Jingna Bao, Wandang Wang, Jiayin Guo, Zhenhua Zeng, Zhongqing Chen, Yong Jiang, Zhanguo Liu, Peng Chen
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
aging
bacterial infection
gut microbiome
macrophage
Online Access:https://doi.org/10.1002/advs.202411008
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