Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS
Ziyuglycoside I and ziyuglycoside II are important active components of Sanguisorba officinalis L., which have excellent pharmacological effects, such as antioxidant and anticancer effects. However, the bioavailability of ziyuglycoside I and ziyuglycoside II has not been reported. This work aims to...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | International Journal of Analytical Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2024/7971021 |
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| author | Xiuwei Shen Ziyue Wang Wenting Li Shenshen Mei Shunjun Ma Xianqin Wang Congcong Wen Fan Chen Guojun Zheng |
| author_facet | Xiuwei Shen Ziyue Wang Wenting Li Shenshen Mei Shunjun Ma Xianqin Wang Congcong Wen Fan Chen Guojun Zheng |
| author_sort | Xiuwei Shen |
| collection | DOAJ |
| description | Ziyuglycoside I and ziyuglycoside II are important active components of Sanguisorba officinalis L., which have excellent pharmacological effects, such as antioxidant and anticancer effects. However, the bioavailability of ziyuglycoside I and ziyuglycoside II has not been reported. This work aims to establish a UPLC-MS/MS method to study the pharmacokinetics of ziyuglycoside I and ziyuglycoside II in rats under different administration routes (intragastric and intravenous administration) and to calculate the bioavailability. The concentration of ziyuglycoside I and ziyuglycoside II in rat plasma in the range of 2–2000 ng/mL showed a good linear relationship (r > 0.99). The intra-day accuracies of ziyuglycoside I and ziyuglycoside II ranged from 87% to 110%, and the inter-day accuracies ranged from 97% to 109%. The intra-day precision was less than 15% and the inter-day precision was less than 14%. The matrix effects ranged from 88% to 113%. The recoveries were all above 84%. The developed UPLC-MS/MS method for the determination of ziyuglycoside I and ziyuglycoside II in rat plasma was applied to pharmacokinetics. The bioavailability of ziyuglycoside I and ziyuglycoside II was measured at 2.6% and 4.6%, respectively. |
| format | Article |
| id | doaj-art-4561e6adc19f406eb27ebaad92846cc1 |
| institution | OA Journals |
| issn | 1687-8779 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Analytical Chemistry |
| spelling | doaj-art-4561e6adc19f406eb27ebaad92846cc12025-08-20T02:37:52ZengWileyInternational Journal of Analytical Chemistry1687-87792024-01-01202410.1155/2024/7971021Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MSXiuwei Shen0Ziyue Wang1Wenting Li2Shenshen Mei3Shunjun Ma4Xianqin Wang5Congcong Wen6Fan Chen7Guojun Zheng8Ruian People’s HospitalLaboratory Animal CentreSchool of Pharmaceutical SciencesLaboratory Animal CentreLaboratory Animal CentreSchool of Pharmaceutical SciencesLaboratory Animal CentreRuian People’s HospitalRuian People’s HospitalZiyuglycoside I and ziyuglycoside II are important active components of Sanguisorba officinalis L., which have excellent pharmacological effects, such as antioxidant and anticancer effects. However, the bioavailability of ziyuglycoside I and ziyuglycoside II has not been reported. This work aims to establish a UPLC-MS/MS method to study the pharmacokinetics of ziyuglycoside I and ziyuglycoside II in rats under different administration routes (intragastric and intravenous administration) and to calculate the bioavailability. The concentration of ziyuglycoside I and ziyuglycoside II in rat plasma in the range of 2–2000 ng/mL showed a good linear relationship (r > 0.99). The intra-day accuracies of ziyuglycoside I and ziyuglycoside II ranged from 87% to 110%, and the inter-day accuracies ranged from 97% to 109%. The intra-day precision was less than 15% and the inter-day precision was less than 14%. The matrix effects ranged from 88% to 113%. The recoveries were all above 84%. The developed UPLC-MS/MS method for the determination of ziyuglycoside I and ziyuglycoside II in rat plasma was applied to pharmacokinetics. The bioavailability of ziyuglycoside I and ziyuglycoside II was measured at 2.6% and 4.6%, respectively.http://dx.doi.org/10.1155/2024/7971021 |
| spellingShingle | Xiuwei Shen Ziyue Wang Wenting Li Shenshen Mei Shunjun Ma Xianqin Wang Congcong Wen Fan Chen Guojun Zheng Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS International Journal of Analytical Chemistry |
| title | Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS |
| title_full | Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS |
| title_fullStr | Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS |
| title_full_unstemmed | Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS |
| title_short | Pharmacokinetics of Ziyuglycoside I and Ziyuglycoside II in Rat Plasma by UPLC-MS/MS |
| title_sort | pharmacokinetics of ziyuglycoside i and ziyuglycoside ii in rat plasma by uplc ms ms |
| url | http://dx.doi.org/10.1155/2024/7971021 |
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