Pharmacological methods for blood stabilization in the extracorporeal circuit (review of literature)
We summarize the possible benefits and risks of using various anticoagulants during hemoperfusion. Clotting in the extracorporeal circuit can lead to a decrease in the effectiveness of therapy, additional workload, risk to the patient and economic losses. At the same time, relatively excessive ant...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2023-02-01
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| Series: | Вестник анестезиологии и реаниматологии |
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| Online Access: | https://www.vair-journal.com/jour/article/view/758 |
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| _version_ | 1849343581169385472 |
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| author | M. S. Mendibaev S. E. Rabotinsky |
| author_facet | M. S. Mendibaev S. E. Rabotinsky |
| author_sort | M. S. Mendibaev |
| collection | DOAJ |
| description | We summarize the possible benefits and risks of using various anticoagulants during hemoperfusion. Clotting in the extracorporeal circuit can lead to a decrease in the effectiveness of therapy, additional workload, risk to the patient and economic losses. At the same time, relatively excessive anticoagulation against the background of existing hemostasis disorders can lead to severe hemorrhagic complications, which in turn worsen the prognosis of patients. The article describes the causes of heparin resistance, the main techniques for overcoming it, and provides practical guidelines for anticoagulant therapy during hemoperfusion. It is well known that routine methods of monitoring hemostasis (such as platelet count, activated partial thromboplastin time) are unable to assess the balance of pro/anticoagulants. The authors have proposed a reasonable personalized approach to anticoagulant therapy of extracorporeal blood purification depending on the pathology in patient and thromboelastography (TEG) data, and antithrombin III levels. |
| format | Article |
| id | doaj-art-4561a489ffd7486c9c9af109a107cd20 |
| institution | Kabale University |
| issn | 2078-5658 2541-8653 |
| language | Russian |
| publishDate | 2023-02-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Вестник анестезиологии и реаниматологии |
| spelling | doaj-art-4561a489ffd7486c9c9af109a107cd202025-08-20T03:42:56ZrusNew Terra Publishing HouseВестник анестезиологии и реаниматологии2078-56582541-86532023-02-01201818810.24884/2078-5658-2023-20-1-81-88573Pharmacological methods for blood stabilization in the extracorporeal circuit (review of literature)M. S. Mendibaev0S. E. Rabotinsky1Demikhov City Clinical HospitalMunicipal Clinical Hospital № 52We summarize the possible benefits and risks of using various anticoagulants during hemoperfusion. Clotting in the extracorporeal circuit can lead to a decrease in the effectiveness of therapy, additional workload, risk to the patient and economic losses. At the same time, relatively excessive anticoagulation against the background of existing hemostasis disorders can lead to severe hemorrhagic complications, which in turn worsen the prognosis of patients. The article describes the causes of heparin resistance, the main techniques for overcoming it, and provides practical guidelines for anticoagulant therapy during hemoperfusion. It is well known that routine methods of monitoring hemostasis (such as platelet count, activated partial thromboplastin time) are unable to assess the balance of pro/anticoagulants. The authors have proposed a reasonable personalized approach to anticoagulant therapy of extracorporeal blood purification depending on the pathology in patient and thromboelastography (TEG) data, and antithrombin III levels.https://www.vair-journal.com/jour/article/view/758hemoperfusionthromboelastogramheparin resistanceanticoagulationextracorporeal circuit |
| spellingShingle | M. S. Mendibaev S. E. Rabotinsky Pharmacological methods for blood stabilization in the extracorporeal circuit (review of literature) Вестник анестезиологии и реаниматологии hemoperfusion thromboelastogram heparin resistance anticoagulation extracorporeal circuit |
| title | Pharmacological methods for blood stabilization in the extracorporeal circuit (review of literature) |
| title_full | Pharmacological methods for blood stabilization in the extracorporeal circuit (review of literature) |
| title_fullStr | Pharmacological methods for blood stabilization in the extracorporeal circuit (review of literature) |
| title_full_unstemmed | Pharmacological methods for blood stabilization in the extracorporeal circuit (review of literature) |
| title_short | Pharmacological methods for blood stabilization in the extracorporeal circuit (review of literature) |
| title_sort | pharmacological methods for blood stabilization in the extracorporeal circuit review of literature |
| topic | hemoperfusion thromboelastogram heparin resistance anticoagulation extracorporeal circuit |
| url | https://www.vair-journal.com/jour/article/view/758 |
| work_keys_str_mv | AT msmendibaev pharmacologicalmethodsforbloodstabilizationintheextracorporealcircuitreviewofliterature AT serabotinsky pharmacologicalmethodsforbloodstabilizationintheextracorporealcircuitreviewofliterature |