Synthesis, recyclization under the action of methanol and analgetic activity of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides

Synthesis, recyclization under the action of methanol and analgetic activity of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides

New methyl 5-aryl-1-(furan-2-carbonyl)-1H-pyrazole-3-carboxylates were obtained via decyclization reaction of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides under the action of methanol. Starting N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides were obtained by intr...

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Main Authors: Sergei N. Igidov, Irina A. Gorbunova, Aleksey Yu. Turyshev, Daria A. Shipilovskikh, Danil A. Kozlov, Anna S. Rogova, Ramiz R. Makhmudov, Pavel S. Silaichev, Nazim M. Igidov
Format: Article
Language:English
Published: Ural Federal University 2022-12-01
Series:Chimica Techno Acta
Subjects:
2,4-dioxobutanoic acid
2-hydrazono-4-oxobutanoic acids
3-hydrazonofuran-2(3h)-one
analgesic activity
drugs
Online Access:https://chimicatechnoacta.ru/article/view/6347
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Summary:New methyl 5-aryl-1-(furan-2-carbonyl)-1H-pyrazole-3-carboxylates were obtained via decyclization reaction of N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides under the action of methanol. Starting N'-(5-aryl-2-oxofuran-3(2H)-ylidene)furan-2-carbohydrazides were obtained by intramolecular cyclization of substituted 4-aryl-2-[2-(furan-2-ylcarbonyl)hydrazinylidene]-4-oxobutanoic acids in propionic anhydride. The structure of the compounds obtained was confirmed by the 1H NMR spectroscopy, IR spectrometry and elemental analysis methods. Analgesic activity of some obtained compounds was studied by the “hot plate” method on outbred white mice of both sexes with intraperitoneal injection.
ISSN:2411-1414

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